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  1. Article: COVID-19 Induced Myocarditis: A Rare Cause of Heart Failure.

    Iqbal, Qasim Z / Haider, Muhammad Adnan / Sattar, Saud Bin Abdul / Hanif, Muhammad / Javid, Ishaq

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11690

    Abstract: ... onset of heart failure secondary to COVID-19 induced myocarditis. ... in the heart and blood vessels, coronavirus can also cause damage to these organs by binding to the ACE-2 ... receptors. A typical case of coronavirus disease 2019 (COVID-19) usually presents with respiratory symptoms ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing lung injury has been well documented in the literature recently. They do so primarily by binding to the membrane-bound form of angiotensin-converting enzyme 2 (ACE-2) receptors. However, since these receptors are also expressed in the heart and blood vessels, coronavirus can also cause damage to these organs by binding to the ACE-2 receptors. A typical case of coronavirus disease 2019 (COVID-19) usually presents with respiratory symptoms like cough and shortness of breath accompanied by fever. The literature regarding this pandemic has been growing and now we know very well that the effect of this deadly virus is not restricted to the lungs alone. It can, unfortunately, cause various other complications ranging from neurological damage to even myocardial injury in rare cases. We present an interesting case of a 40-year-old male patient who presented to us with shortness of breath. When further investigated, the patient was found to have a new onset of heart failure secondary to COVID-19 induced myocarditis.
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acute Pericarditis Post mRNA-1273 COVID Vaccine Booster.

    Singh, Arminder / Nguyen, Lam / Everest, Stephanie / Afzal, Safi / Shim, Ahmed

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22148

    Abstract: ... myocardial infarction, heart failure, and myocarditis are rare but seen in COVID-19 patients. These cardiac injuries ... for cardiac complications in COVID-19 patients is macrophage-induced inflammation. The SARS-CoV-2 infection ... side effects can also be seen infrequently. The exact pathogenesis of COVID-19 vaccine-induced pericarditis ...

    Abstract Cardiovascular complications such as arrhythmias, hypoxemic cardiomyopathy, pericarditis, myocardial infarction, heart failure, and myocarditis are rare but seen in COVID-19 patients. These cardiac injuries could be the result of direct SARS-CoV-2 effects. The most prominent mediator of this hypothesis is angiotensin-converting enzyme-2 (ACE2) receptors, which are highly expressed in heart and lung tissues. These ACE2 receptors are found to be the functional receptors for the Coronavirus. Another hypothesis for cardiac complications in COVID-19 patients is macrophage-induced inflammation. The SARS-CoV-2 infection leads to invasion of epithelial cells by binding with ACE-2 receptors, localized inflammation, endothelial and macrophage activation, tissue damage, and dysregulated cytokine release. Current data have shown that mRNA COVID-19 vaccines are efficacious and safe for indicated patients. However, these vaccines can cause mild adverse reactions similar to those of traditional vaccines, and more severe side effects can also be seen infrequently. The exact pathogenesis of COVID-19 vaccine-induced pericarditis remains unknown, but there are several hypotheses regarding the pathophysiology of pericarditis after COVID-19 vaccine administrations. There has been speculation that mRNA vaccines can produce a large number of antibodies in a small subgroup of people, especially young individuals, and this elicits an inflammatory response similar to the multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Another proposed mechanism is the cross-reaction between produced antibodies and the pericardium, leading to myocardial and pericardial inflammation induction. This report describes a 69-year-old female who presented with three days of chest pain that started one day after a booster shot of the Moderna COVID-19 vaccine. The patient was diagnosed with pericarditis, and she was effectively treated with colchicine and later steroids.
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: mRNA vaccines for COVID-19 are safe and clinically effective in patients with cardiac amyloidosis.

    Barzen, Gina / Rieber, Finn / Stangl, Karl / Hahn, Katrin / Spethmann, Sebastian

    Vaccine

    2023  Volume 42, Issue 4, Page(s) 723–726

    Abstract: ... since 2020. Risk factors for a severe course include pre-existing cardiac diseases like heart failure and ... of the patients had symptoms of worsening heart failure in temporal relation to the vaccination. Most ... spontaneously. There was no clinical or laboratory evidence of suspected vaccine-induced myocarditis. Five ...

    Abstract Introduction: Amyloidosis is a rare disease in which malformed proteins are deposited in tissues occurring mostly commonly in older age. These deposits can lead to severe organ dysfunction e.g. in the myocardium with great impact on prognosis. The Covid-19 pandemic has caused excess mortality worldwide since 2020. Risk factors for a severe course include pre-existing cardiac diseases like heart failure and advanced age. Therefore, vaccination against Sars-CoV2 viruses is highly recommended for patients with cardiac amyloidosis. However, since there are no specific data on mRNA vaccines in patients with cardiac amyloidosis, some patients have concerns about cardiac adverse events following immunization (AEFI), such as myocarditis.
    Purpose: The purpose of the study is to assess the safety and efficacy of mRNA vaccines in patients with cardiac amyloidosis.
    Methods: Patients of the Amyloidosis Center Charité Berlin (ACCB) were assessed about the vaccination, its tolerability and clinical effectiveness. To date, we included 62 patients (54 men) with a median age of 82,5 years (range 37 to 92). 46 patients had wtATTR amyloidosis, ten patients had hATTR amyloidosis, and six patients had AL amyloidosis. The mean systolic left ventricular function was 51% (range 30 to 62) with a mean global strain of -11,5% (range -18,5 to -3,1). The mean NT-pro-BNP was 1145 ng/l (range 24 to 48297).
    Results: 59 patients were triple vaccinated and three patients so far are double vaccinated. Three of the patients were unvaccinated. 171 of the vaccine doses administered were mRNA vaccines and eight doses were a viral vector-vaccine. None of the patients reported severe side effects. Thirteen patients reported feeling of pressure and pain at the injection site after vaccination and four patients had fever of maximum two days, eight patients reported lower general condition of maximum five days. One patient reported malaise for 14 days after each vaccination, which resolved spontaneously. There was no clinical or laboratory evidence of suspected vaccine-induced myocarditis. Five patients reported of a COVID-19 breakthrough infection, all of which with a mild course of disease. None of the patients had symptoms of worsening heart failure in temporal relation to the vaccination. Most of the vaccinations (103) were performed at an official vaccination center, 59 were performed at a general practitioner.
    Conclusion: In patients with cardiac amyloidosis, mRNA vaccines for COVID-19 are safe with respect to severe cardiac adverse events and show effective protection against clinically relevant SARS-CoV2 infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Amyloidosis ; Breakthrough Infections ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Heart Failure ; mRNA Vaccines ; Myocarditis ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines ; RNA, Viral
    Language English
    Publishing date 2023-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.12.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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