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  1. Article: Serum levels of thrombotic markers in patients with acute myocardial infarction.

    Islam, Shafiqul / Yakout, Sobhy M / Daghri, Nasser M Al / Alhomida, Abdullah S / Khan, Haseeb A

    International journal of clinical and experimental medicine

    2014  Volume 7, Issue 4, Page(s) 1059–1063

    Abstract: ... we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors ... TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway ... of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non ...

    Abstract Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro- and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
    Language English
    Publishing date 2014-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2418305-2
    ISSN 1940-5901
    ISSN 1940-5901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Soluble elastin fragments in serum are elevated in aortic dissection].

    Shinohara, Tadashi / Suzuki, Kimihiro / Okada, Makoto / Shigai, Masaru / Shimizu, Masashi / Maehara, Tadaaki / Ohsuzu, Fumitaka

    Journal of cardiology

    2004  Volume 43, Issue 2, Page(s) 96–97

    Abstract: ... Twenty-five acute aortic dissection patients, 50 patients with acute myocardial infarction, and 474 ... acute myocardial infarction patient was positive (2.0%). Acute aortic dissection patients ... of simplified laboratory test(s) to help diagnose and screen acute aortic dissection patients is ...

    Abstract Objectives: We aimed to establish an enzyme-linked immunosorbent assay (ELISA) for measuring soluble elastin fragments (sELAF) in serum and to reveal its usefulness in diagnosing acute aortic dissection.
    Background: Acute aortic dissection is a life-threatening disease of the aorta. However, the diagnosis is still frequently missed, especially at onset. The establishment and clinical availability of simplified laboratory test(s) to help diagnose and screen acute aortic dissection patients is therefore urgently needed.
    Methods and results: An ELISA to measure sELAF in serum was developed using the newly created double monoclonal antibodies which recognize the different epitopes of human aortic elastin. Twenty-five acute aortic dissection patients, 50 patients with acute myocardial infarction, and 474 healthy individuals were enrolled in the study. The sELAF levels from healthy subjects gradually increased with aging. When the cutoff point for positivity was set at the mean + 3SD above the mean of those in healthy subjects at each age, 16 acute aortic dissection patients (64.0%) were found to be positive, while only one acute myocardial infarction patient was positive (2.0%). Acute aortic dissection patients with either an open or a partially open pseudolumen were found to be 88.9% positive for sELAF, while those with its early closure was 0% positive. The difference in the sELAF levels between acute aortic dissection patients with and without a thrombotic closure of false lumen was significant (60.3 +/- 15.6 vs 135.4 +/- 53.2 ng/ml, p < 0.005).
    Conclusions: The sELAF level in serum may be a useful marker for helping both diagnose and screen acute aortic dissection, while also helping distinguish acute aortic dissection from acute myocardial infarction.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aneurysm, Dissecting/diagnosis ; Aortic Aneurysm/diagnosis ; Biomarkers/blood ; Elastin/blood ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Middle Aged ; Solubility
    Chemical Substances Biomarkers ; Elastin (9007-58-3)
    Language Japanese
    Publishing date 2004-02
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0914-5087 ; 0386-2887
    ISSN (online) 1876-4738
    ISSN 0914-5087 ; 0386-2887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1794: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Soluble elastin fragments in serum are elevated in acute aortic dissection.

    Shinohara, Tadashi / Suzuki, Kimihiro / Okada, Makoto / Shiigai, Masaru / Shimizu, Masashi / Maehara, Tadaaki / Ohsuzu, Fumitaka

    Arteriosclerosis, thrombosis, and vascular biology

    2003  Volume 23, Issue 10, Page(s) 1839–1844

    Abstract: ... aortic elastin. Twenty-five AAD patients, 50 patients with acute myocardial infarction (AMI), and 474 ... in the sELAF levels between AAD patients with and without a thrombotic closure of false lumen was significant ... elastin fragments (sELAF) in serum and to reveal its usefulness in diagnosing acute aortic dissection (AAD ...

    Abstract Objective: We aimed to establish an enzyme-linked immunosorbent assay for measuring soluble elastin fragments (sELAF) in serum and to reveal its usefulness in diagnosing acute aortic dissection (AAD).
    Methods and results: An enzyme-linked immunosorbent assay to measure sELAF in serum was developed by using the newly created double monoclonal antibodies, which recognize the different epitopes of human aortic elastin. Twenty-five AAD patients, 50 patients with acute myocardial infarction (AMI), and 474 healthy individuals were enrolled in the study. The sELAF levels from healthy subjects gradually increased with aging. When the cutoff point for positivity was set at the mean+3 SD (ie, 3 SD above the mean in healthy subjects at each age), 16 AAD patients (64.0%) were found be positive, whereas only 1 AMI patient was found to be positive (2.0%). AAD patients with either an open or a partially open pseudolumen were found be 88.9% positive for sELAF, whereas those with its early closure were 0% positive. The difference in the sELAF levels between AAD patients with and without a thrombotic closure of false lumen was significant (60.3+/-15.6 versus 135.4+/-53.2 ng/mL, respectively; P<0.005).
    Conclusions: The sELAF level in serum may be a useful marker for helping in the diagnosis and screening of AAD and may also help to distinguish AAD from AMI.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Aneurysm, Dissecting/blood ; Aneurysm, Dissecting/diagnosis ; Aortic Aneurysm/blood ; Aortic Aneurysm/diagnosis ; Biomarkers/blood ; Case-Control Studies ; Diagnosis, Differential ; Elastin/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Reference Values ; Risk Factors
    Chemical Substances Biomarkers ; Elastin (9007-58-3)
    Language English
    Publishing date 2003-10-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/01.ATV.0000085016.02363.80
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Serum lipoprotein(a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarction.

    Haider, A W / Andreotti, F / Thompson, G R / Kluft, C / Maseri, A / Davies, G J

    Circulation

    1996  Volume 94, Issue 9, Page(s) 2072–2076

    Abstract: ... and results: Thirty-two patients (23 men, 9 women: age, 30 to 70 years) with acute ... myocardial infarction in humans is associated with a higher level of lipoprotein(a) and of a marker of thrombin ... in the early, evolving phase of acute myocardial infarction. To assess their relationship to this pattern ...

    Abstract Background: Thrombotic occlusion of the infarct-related coronary artery is often intermittent in the early, evolving phase of acute myocardial infarction. To assess their relationship to this pattern of coronary occlusion, serum or plasma concentrations of cholesterol, triglyceride, lipoprotein(a), and coagulation and fibrinolytic factors were measured in venous blood before the initiation of thrombolytic therapy.
    Methods and results: Thirty-two patients (23 men, 9 women: age, 30 to 70 years) with acute myocardial infarction received intravenous recombinant tissue plasminogen activator (20 to 60 megaunits) within 6 hours of the onset of symptoms. Continuous ECG ST-segment recording demonstrated intermittent occlusion of the infarct-related coronary artery in 12 patients (group 1) before the start of thrombolytic treatment and persistent occlusion in 20 patients (group 2). Groups 1 and 2 were similar in age, sex, race, duration of symptoms, blood sample collection time, location of the infarct-related coronary artery, and extent of coronary artery disease. The serum level (median [interquartile range]) of lipoprotein(a) was 34 (13 to 47) mg/dL versus 11.5 (5 to 27) mg/dL (P = .02), and the plasma level (median [interquartile range]) of thrombin-antithrombin III complex was 10.85 (6.4 to 21.5) versus 6.8 (4.2 to 8.7) micrograms/L-1 (P < .04) in groups 1 and 2, respectively. The levels of the other factors were similar in both groups.
    Conclusions: The phenomenon of spontaneous intermittent closure and reopening of coronary arteries early during acute myocardial infarction in humans is associated with a higher level of lipoprotein(a) and of a marker of thrombin generation, suggesting that lipoprotein(a) and thrombin are closely related to coronary patency in these patients.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Biomarkers ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Coronary Disease/blood ; Coronary Disease/complications ; Electrocardiography ; Female ; Fibrinogen/metabolism ; Fibrinolysin/metabolism ; Hemostasis/physiology ; Humans ; Lipids/blood ; Lipoprotein(a)/blood ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/etiology ; Plasminogen Activators/administration & dosage ; Thrombin/biosynthesis ; Time Factors ; Tissue Plasminogen Activator/administration & dosage ; Triglycerides/blood ; von Willebrand Factor/metabolism
    Chemical Substances Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Lipids ; Lipoprotein(a) ; Triglycerides ; von Willebrand Factor ; Fibrinogen (9001-32-5) ; Plasminogen Activators (EC 3.4.21.-) ; Thrombin (EC 3.4.21.5) ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolysin (EC 3.4.21.7)
    Language English
    Publishing date 1996-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.cir.94.9.2072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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