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  1. TI=Risk of pregnancy loss before 20 weeks gestation in study participants with COVID 19
  2. TI=Status epilepticus and COVID 19: A systematic review

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  1. Article ; Online: Risk of pregnancy loss before 20 weeks' gestation in study participants with COVID-19.

    Jacoby, Vanessa L / Murtha, Amy / Afshar, Yalda / Gaw, Stephanie L / Asiodu, Ifeyinwa / Tolosa, Jorge / Norton, Mary E / Boscardin, W John / Flaherman, Valerie

    American journal of obstetrics and gynecology

    2021  Volume 225, Issue 4, Page(s) 456–457

    MeSH term(s) Abortion, Spontaneous/etiology ; Adult ; COVID-19/complications ; Female ; Gestational Age ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; SARS-CoV-2
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2021.06.080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: mRNA COVID-19 vaccination early in pregnancy and the risk of spontaneous abortion in an international pregnancy registry.

    Mansour, Omar / Hernandez-Diaz, Sonia / Wyszynski, Diego F

    Pharmacoepidemiology and drug safety

    2023  Volume 32, Issue 6, Page(s) 685–693

    Abstract: ... the first 20 weeks of gestation on the risk of spontaneous abortion (SAB).: Methods: All pregnant ... There were 37 SABs, with an overall 13.4% estimated cumulative risk by 20 weeks of gestation, which is ... of gestation, SAB, or loss to follow-up. Baseline demographics, vaccination information, and pregnancy ...

    Abstract Purpose: mRNA COVID-19 vaccines are used in pregnant populations whether advertently or inadvertently. However, evidence on the safety of these vaccines during pregnancy is limited. The objective of this study is to evaluate the effect of BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccination during the first 20 weeks of gestation on the risk of spontaneous abortion (SAB).
    Methods: All pregnant women who received at least one dose of BNT162b2 or mRNA-1273 and enrolled in the COVID-19 Vaccines International Pregnancy Exposure Registry (C-VIPER) were prospectively followed from enrollment until 20 weeks of gestation, SAB, or loss to follow-up. Baseline demographics, vaccination information, and pregnancy outcomes were collected via monthly online self-administered questionnaires, vaccination certificates, and medical records. Life tables were used to calculate the cumulative risk of SAB. Cox regression was used to estimate the hazard ratio (HR) comparing the two vaccines groups stratified by country of residence and gestational age at enrollment.
    Results: Among 6840 participants who received at least one dose of BNT162b2 or mRNA-1273 at any time in pregnancy between Jan-Sep, 2021, 2129 met the inclusion criteria (1576 received BNT162b2 and 553 mRNA-1273). The two groups were balanced in terms of baseline characteristics. There were 37 SABs, with an overall 13.4% estimated cumulative risk by 20 weeks of gestation, which is similar to the expected risk in the population. The HR of SAB comparing mRNA-1273 to BNT162b2 was 1.46 (95% CI: 0.66, 3.22).
    Conclusion: The C-VIPER data show no evidence that mRNA COVID-19 vaccines increase the risk of SAB.
    MeSH term(s) Pregnancy ; Female ; Humans ; Abortion, Spontaneous ; COVID-19 Vaccines ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19 ; Vaccination ; RNA, Messenger ; Registries
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; RNA, Messenger
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3395: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Timing and severity of COVID-19 during pregnancy and risk of preterm birth in the International Registry of Coronavirus Exposure in Pregnancy.

    Smith, Louisa H / Dollinger, Camille Y / VanderWeele, Tyler J / Wyszynski, Diego F / Hernández-Díaz, Sonia

    BMC pregnancy and childbirth

    2022  Volume 22, Issue 1, Page(s) 775

    Abstract: ... associated with preterm delivery. In contrast, severe COVID-19 after 20 weeks' gestation led to an increase ... were censored at time of their last follow-up. Participants with symptomatic COVID-19 before 20 weeks' ... Severe COVID-19 late in pregnancy sharply increased the risk of preterm delivery compared to no COVID-19 ...

    Abstract Background: Studies of preterm delivery after COVID-19 are often subject to selection bias and do not distinguish between early vs. late infection in pregnancy, nor between spontaneous vs. medically indicated preterm delivery. This study aimed to estimate the risk of preterm birth (overall, spontaneous, and indicated) after COVID-19 during pregnancy, while considering different levels of disease severity and timing.
    Methods: Pregnant and recently pregnant people who were tested for or clinically diagnosed with COVID-19 during pregnancy enrolled in an international internet-based cohort study between June 2020 and July 2021. We used several analytic approaches to minimize confounding and immortal time bias, including multivariable regression, time-to-delivery models, and a case-time-control design.
    Results: Among 14,264 eligible participants from 70 countries who did not report a pregnancy loss before 20 gestational weeks, 5893 had completed their pregnancies and reported delivery information; others were censored at time of their last follow-up. Participants with symptomatic COVID-19 before 20 weeks' gestation had no increased risk of preterm delivery compared to those testing negative, with adjusted risks of 10.0% (95% CI 7.8, 12.0) vs. 9.8% (9.1, 10.5). Mild COVID-19 later in pregnancy was not clearly associated with preterm delivery. In contrast, severe COVID-19 after 20 weeks' gestation led to an increase in preterm delivery compared to milder disease. For example, the risk ratio for preterm delivery comparing severe to mild/moderate COVID-19 at 35 weeks was 2.8 (2.0, 4.0); corresponding risk ratios for indicated and spontaneous preterm delivery were 3.7 (2.0, 7.0) and 2.3 (1.2, 3.9), respectively.
    Conclusions: Severe COVID-19 late in pregnancy sharply increased the risk of preterm delivery compared to no COVID-19. This elevated risk was primarily due to an increase in medically indicated preterm deliveries, included preterm cesarean sections, although an increase in spontaneous preterm delivery was also observed. In contrast, mild or moderate COVID-19 conferred minimal risk, as did severe disease early in pregnancy.
    MeSH term(s) Female ; Pregnancy ; Infant, Newborn ; Humans ; Premature Birth/epidemiology ; COVID-19/epidemiology ; Cohort Studies ; Gestational Age ; Registries ; Pregnancy Outcome/epidemiology
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-022-05101-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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