Article ; Online: Is there a correlation between viral load and olfactory & taste dysfunction in COVID-19 patients?
American journal of otolaryngology
2021 Volume 42, Issue 3, Page(s) 102911
Abstract: ... with OTD had a lower Ct value at diagnosis, and hence, a higher viral load than those without OTD ... The evaluation of Ct value and viral load in COVID-19 patients may help in further reducing the transmission ... of olfactory and taste dysfunction in COVID-19 patients.: Methods: This comparative study included COVID-19 ...
| Abstract | Objectives: To evaluate the correlation between cycle threshold (Ct) value and occurrence of olfactory and taste dysfunction in COVID-19 patients. Methods: This comparative study included COVID-19 patients diagnosed by reverse transcription- polymerase chain reaction (RT-PCR) based test at our hospital with mild to moderate disease. The demographic details and detailed clinical history of the patient, including history of loss of smell and taste was taken at the time of presentation. The patients were divided into 2 groups, group A: COVID-19 patients with OTD; group B: COVID-19 patients without OTD. 100 contiguous patients were recruited in each group. The COVID-19 test by RT-PCR was done and Ct value of the 3 genes: E (Envelope encoding) gene, N (Nucleocapsid encoding) gene, and RdRp (RNA-dependent RNA polymerase) gene, was used for data analysis. The Ct values of each of the three genes were compared between groups A and B. Results: Group A and B did not differ significantly in terms of basic demographics. The differences in the Ct values of the 3 genes E gene, N gene and RdRp gene, of group A and B were found to be statistically significant (p = 0.005, p = 0.001 and p = 0.002, respectively). Conclusion: The patients with OTD had a lower Ct value at diagnosis, and hence, a higher viral load than those without OTD. The evaluation of Ct value and viral load in COVID-19 patients may help in further reducing the transmission of the virus in the community. |
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| MeSH term(s) | Adult ; COVID-19/complications ; Female ; Humans ; Male ; Olfaction Disorders/virology ; SARS-CoV-2 ; Taste Disorders/virology ; Viral Load |
| Language | English |
| Publishing date | 2021-01-12 |
| Publishing country | United States |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 604541-8 |
| ISSN | 1532-818X ; 0196-0709 |
| ISSN (online) | 1532-818X |
| ISSN | 0196-0709 |
| DOI | 10.1016/j.amjoto.2021.102911 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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