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  1. Article: Prolonged SARS-CoV2 Viral Shedding in an Elderly Patient.

    Jariwal, Roopam / Raza, Nadia / Valdez, Michael / Aboeed, Ayham / Garcia-Pacheco, Ralph

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15128

    Abstract: ... storm caused by the virus. In the past, prolonged viral shedding of Middle East Respiratory Syndrome ... holds true for severe acute respiratory syndrome coronavirus (SARS-CoV2). To our knowledge ... this case report highlights the longest reported disease course of SARS-CoV2, lasting approximately 210 days. ...

    Abstract Coronavirus disease 2019 (COVID-19) has been devastating to the elderly population, especially due to a lack of clear guidelines for treatment. Corticosteroids have been the mainstay in treating the cytokine storm caused by the virus. In the past, prolonged viral shedding of Middle East Respiratory Syndrome (MERS) was noted in patients treated with high-dose corticosteroids. It is unclear whether this also holds true for severe acute respiratory syndrome coronavirus (SARS-CoV2). To our knowledge, this case report highlights the longest reported disease course of SARS-CoV2, lasting approximately 210 days.
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report.

    Daher, Ayham / Müller, Tobias / Spiesshoefer, Jens / Dreher, Michael / Panse, Jens

    Respiratory medicine case reports

    2021  Volume 34, Page(s) 101560

    Abstract: ... binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR ... monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening ... A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 ...

    Abstract A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibiotic therapy. After administration of bamlanivimab, a monoclonal antibody with high affinity for the receptor-binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR became negative, and the patient improved clinically and radiologically. In conclusion, we demonstrated successful treatment of prolonged COVID-19 in a patient with severe B-cell aplasia with a virus-neutralizing monoclonal antibody.
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2021.101560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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