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  1. Article: Thrombotic events in COVID-19 patients: A case series and literature review.

    Javidarabshahi, Zahra / Khatami, Shohre / Rezazade, Roxana / Saeedian, Neda / Mozdourian, Mahnaz

    Caspian journal of internal medicine

    2020  Volume 11, Issue Suppl 1, Page(s) 551–556

    Abstract: ... Here, we present six cases of thrombotic events in patients with COVID-19.: Case presentation ... In this case series, we present six patients with confirmed COVID-19, according ... that COVID-19 puts the patients at an increased risk for developing thrombotic conditions, possibly ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has rapidly emerged as a threatening pandemic. Clinical features of this pandemic involve a wide range of manifestations and are not completely known. Here, we present six cases of thrombotic events in patients with COVID-19.
    Case presentation: In this case series, we present six patients with confirmed COVID-19, according to real-time polymerase chain reaction, who were referred to our emergency department and were found to have thrombotic events. Pulmonary thromboembolism was diagnosed in three patients by computed tomography (CT) angiography. One patient was found to have deep vein thrombosis in Doppler ultrasonography. Another patient who presented with loss of consciousness was finally diagnosed with a cerebrovascular accident using brain CT. One of the patients had developed a myocardial infarction evident on the electrocardiogram.
    Conclusion: It is ostensible that COVID-19 puts the patients at an increased risk for developing thrombotic conditions, possibly through formation of hyper-inflammatory and hyper-coagulative states. However, further prospective studies are recommended to confirm these findings.
    Language English
    Publishing date 2020-12-19
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.11.0.551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thrombotic events in COVID-19 patients

    Zahra Javidarabshahi / Shohre Khatami / Roxana Rezazade / Neda Saeedian / Mahnaz Mozdourian

    Caspian Journal of Internal Medicine, Vol 11, Iss Supplement 1, Pp 551-

    a case series and literature review

    2020  Volume 556

    Abstract: ... Here, we present six cases of thrombotic events in patients with COVID-19. Case presentation ... In this case series, we present six patients with confirmed COVID-19, according ... that COVID-19 puts the patients at an increased risk for developing thrombotic conditions, possibly ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has rapidly emerged as a threatening pandemic. Clinical features of this pandemic involve a wide range of manifestations and are not completely known. Here, we present six cases of thrombotic events in patients with COVID-19. Case presentation: In this case series, we present six patients with confirmed COVID-19, according to real-time polymerase chain reaction, who were referred to our emergency department and were found to have thrombotic events. Pulmonary thromboembolism was diagnosed in three patients by computed tomography (CT) angiography. One patient was found to have deep vein thrombosis in Doppler ultrasonography. Another patient who presented with loss of consciousness, was finally diagnosed with cerebrovascular accident using brain CT. One of the patients had developed a myocardial infarction that was evident in the electrocardiography. Conclusion: It is ostensible that COVID-19 puts the patients at an increased risk for developing thrombotic conditions, possibly through formation of hyper-inflammatory and hyper-coagulative states. However, further prospective studies are recommended to confirm these findings.
    Keywords coronavirus disease 2019 ; thrombosis ; myocardial infarction ; pulmonary thromboembolism ; venous thrombosis ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Babol University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Thrombosis and Bleeding in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: A Systematic Review of Published Cases.

    Clerici, Bianca / Pontisso, Eleonora / Aloise, Chiara / Peroni, Benedetta / Perricone, Rosaria / Pisetta, Chiara / Scavone, Mariangela / Birocchi, Simone / Podda, Gian Marco

    Thrombosis and haemostasis

    2023  Volume 124, Issue 5, Page(s) 423–431

    Abstract: ... case reports and case series providing nonaggregate data of VITT patients. Accurate VITT diagnosis required ... was 24% (95% CI: 19-29), and 77% (95% CI: 58-90) in patients with isolated CVST complicated by ICH ... We performed a systematic review of the literature (PubMed and Embase) up to July 31, 2022, including ...

    Abstract Introduction:  Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic reaction to COVID-19 (coronavirus disease 2019) adenoviral vector vaccines. Its distinct bleeding and thrombotic patterns compared with other platelet consumptive disorders remain unclear.
    Methods:  We performed a systematic review of the literature (PubMed and Embase) up to July 31, 2022, including case reports and case series providing nonaggregate data of VITT patients. Accurate VITT diagnosis required fulfillment of the following criteria: (1) endorsement by the authors, (2) consistent vaccine type and timing, (3) presence of thrombocytopenia and thrombosis, (4) detection of anti-platelet factor 4 antibodies. Data are presented as frequencies with 95% confidence intervals (CIs) calculated with the exact binomial method.
    Results:  We retrieved 143 eligible studies, describing 366 patients. Of 647 thrombotic events, 53% (95% CI: 49-56) were venous thromboses at unusual sites and 30% (95% CI: 27-34) were cerebral venous sinus thromboses (CVSTs). The ratio of venous-to-arterial events was 4.1. Thromboses in most sites were associated with at least another thrombotic event, with the exception of CVST and CNS arterial thrombosis (isolated in 49 and 39% of cases, respectively). Bleeding occurred in 36% (95% CI: 31-41) of patients; 68% (95% CI: 59-75) of bleeding events were intracranial hemorrhages (ICHs). Overall mortality was 24% (95% CI: 19-29), and 77% (95% CI: 58-90) in patients with isolated CVST complicated by ICH.
    Conclusion:  VITT displays a venous-to-arterial thrombosis ratio comparable to heparin-induced thrombocytopenia. However, VITT is characterized by a higher prevalence of CVST and ICH, which contribute to the increased bleeding frequency and mortality.
    MeSH term(s) Humans ; Anticoagulants/adverse effects ; Case Reports as Topic ; COVID-19/complications ; COVID-19 Vaccines/adverse effects ; Hemorrhage ; Platelet Factor 4/immunology ; Risk Factors ; SARS-CoV-2/immunology ; Sinus Thrombosis, Intracranial/etiology ; Thrombosis/etiology ; Venous Thrombosis
    Chemical Substances Anticoagulants ; COVID-19 Vaccines ; Platelet Factor 4 (37270-94-3)
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Systematic Review ; Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0043-1777134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 433: Show issues

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  4. Article: Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review.

    Ferraro, Jennifer J / Reynolds, Allie / Edoigiawerie, Sylvia / Seu, Michelle Y / Horen, Sydney R / Aminzada, Amir / Hamidian Jahromi, Alireza

    World journal of methodology

    2022  Volume 12, Issue 6, Page(s) 476–487

    Abstract: ... of the literature on COVID-19 infections that led to thrombotic complications necessitating surgical intervention ... available English medical literature on surgical interventions necessitated by COVID-19 thrombotic ... this association. The purpose of this study was to perform a systematic review and meta-analysis of the literature ...

    Abstract Background: Several unique clinical features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19) infection, have been identified and characterized. One such feature, mostly among patients with severe COVID-19 infection, has become known as COVID-19-induced coagulopathy. Surgical patients with a history of or active COVID-19 infection bear a significantly higher risk for postoperative thrombotic complications. These patients may require surgical intervention to treat severe thrombotic complications. Few studies have been carried out to better characterize this association. The purpose of this study was to perform a systematic review and meta-analysis of the literature on COVID-19 infections that led to thrombotic complications necessitating surgical intervention. We hypothesized that patients with recent or active COVID-19 infection would have high rates of thromboembolic complications both arterial and venous in origin.
    Aim: To perform a systematic review and meta-analysis of the literature on COVID-19 infections that led to thrombotic complications necessitating surgical intervention.
    Methods: The current systematic review implemented an algorithmic approach to review all the currently available English medical literature on surgical interventions necessitated by COVID-19 thrombotic complications using the preferred reporting items for systematic reviews and meta-analysis principles. A comprehensive search of the medical literature in the "PubMed", "Scopus", "Google Scholar" top 100 results, and archives of
    Results: The database search resulted in the final inclusion of 22 retrospective studies, after application of the inclusion/exclusion criteria. Of the included studies, 17 were single case reports, 3 were case series and 2 were cross sectional cohort studies. All studies were retrospective in nature. Twelve of the reported studies were conducted in the United States of America, with the remaining studies originating from Italy, Turkey, Pakistan, France, Serbia, and Germany. All cases reported in our study were laboratory confirmed SARS-CoV-2 positive. A total of 70 cases involving surgical intervention were isolated from the 22 studies included in this review.
    Conclusion: There is paucity of data describing the relationship between COVID-19 infection and thrombotic complications necessitating the need for surgical intervention. Intestinal ischemia and acute limb ischemia are amongst the most common thrombotic events due to COVID-19 that required operative management. An overall postoperative mortality of 30% was found in those who underwent operative procedures for thrombotic complications, with most deaths occurring in those with bowel ischemia. Physicians should be aware that despite thromboprophylaxis, severe thrombotic complications can still occur in this patient population, however, surgical intervention results in relatively low mortality apart from cases of ischemic bowel resection.
    Language English
    Publishing date 2022-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 2222-0682
    ISSN 2222-0682
    DOI 10.5662/wjm.v12.i6.476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Thrombosis and Bleeding in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: A Systematic Review of Published Cases

    Clerici, Bianca / Pontisso, Eleonora / Aloise, Chiara / Peroni, Benedetta / Perricone, Rosaria / Pisetta, Chiara / Scavone, Mariangela / Birocchi, Simone / Podda, Gian Marco

    Thrombosis and Haemostasis

    2023  Volume 124, Issue 05, Page(s) 423–431

    Abstract: ... case reports and case series providing nonaggregate data of VITT patients. Accurate VITT diagnosis required ... was 24% (95% CI: 19–29), and 77% (95% CI: 58–90) in patients with isolated CVST complicated by ICH ... We performed a systematic review of the literature (PubMed and Embase) up to July 31, 2022, including ...

    Abstract Introduction: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic reaction to COVID-19 (coronavirus disease 2019) adenoviral vector vaccines. Its distinct bleeding and thrombotic patterns compared with other platelet consumptive disorders remain unclear.
    Methods: We performed a systematic review of the literature (PubMed and Embase) up to July 31, 2022, including case reports and case series providing nonaggregate data of VITT patients. Accurate VITT diagnosis required fulfillment of the following criteria: (1) endorsement by the authors, (2) consistent vaccine type and timing, (3) presence of thrombocytopenia and thrombosis, (4) detection of anti-platelet factor 4 antibodies. Data are presented as frequencies with 95% confidence intervals (CIs) calculated with the exact binomial method.
    Results: We retrieved 143 eligible studies, describing 366 patients. Of 647 thrombotic events, 53% (95% CI: 49–56) were venous thromboses at unusual sites and 30% (95% CI: 27–34) were cerebral venous sinus thromboses (CVSTs). The ratio of venous-to-arterial events was 4.1. Thromboses in most sites were associated with at least another thrombotic event, with the exception of CVST and CNS arterial thrombosis (isolated in 49 and 39% of cases, respectively). Bleeding occurred in 36% (95% CI: 31–41) of patients; 68% (95% CI: 59–75) of bleeding events were intracranial hemorrhages (ICHs). Overall mortality was 24% (95% CI: 19–29), and 77% (95% CI: 58–90) in patients with isolated CVST complicated by ICH.
    Conclusion: VITT displays a venous-to-arterial thrombosis ratio comparable to heparin-induced thrombocytopenia. However, VITT is characterized by a higher prevalence of CVST and ICH, which contribute to the increased bleeding frequency and mortality.
    Keywords adenovirus ; platelet ; hemorrhage ; thrombocytopenia ; thrombosis
    Language English
    Publishing date 2023-12-18
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0043-1777134
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 433: Show issues

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  6. Article ; Online: A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination

    Luca Roncati / Antonio Manenti / Lorenzo Corsi

    Pathogens, Vol 11, Iss 435, p

    2022  Volume 435

    Abstract: ... literature review, the same adverse events can rarely occur with modRNA vaccines too. In support of this, we here ... report a three-case series of thrombotic deaths in patients over 50 with comorbidities temporally after ... quite similar morphologically to those described in patients who died from severe COVID-19. Even ...

    Abstract Coronavirus disease 2019 (COVID-19) is the most dramatic pandemic of the new millennium; to counteract it, specific vaccines have been launched in record time under emergency use authorization or conditional marketing authorization by virtue of a favorable risk/benefit balance. Among the various technological platforms, there is that exploiting a nucleoside-modified messenger RNA (modRNA), such as Comirnaty ® , and that which is adenoviral vector-based. In the ongoing pharmacovigilance, the product information of the latter has been updated about the risk of thrombotic thrombocytopenia, venous thromboembolism without thrombocytopenia and immune thrombocytopenia without thrombosis. However, from an in-depth literature review, the same adverse events can rarely occur with modRNA vaccines too. In support of this, we here report a three-case series of thrombotic deaths in patients over 50 with comorbidities temporally after Comirnaty ® , investigated by means of post-mortem histopathology and immunohistochemistry. In two out of three cases, the cause of death is traced back to pulmonary microthromboses rich in activated platelets, quite similar morphologically to those described in patients who died from severe COVID-19. Even if remote in the face of millions of administered doses, clinicians should be aware of the possible thrombotic risk also after Comirnaty ® , in order to avoid a misdiagnosis with potentially lethal consequences. Since COVID-19 vaccines are inoculated in subjects to be protected, maximum attention must be paid to their safety, and prophylactic measures to increase it are always welcome. In light of the evidence, the product information of modRNA COVID-19 vaccines should be updated about the thrombotic risk, as happened for adenoviral vector-based vaccines.
    Keywords coronavirus disease 2019 (COVID-19) ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ; nucleoside-modified messenger RNA (modRNA) ; Comirnaty ® ; Pfizer/BioNTech COVID-19 Vaccine ; autopsy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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