Article ; Online: COVID-19 in hospitalized liver transplant recipients: An early systematic review and meta-analysis.
2021 Volume 35, Issue 4, Page(s) e14246
Abstract: ... among hospitalized LTx recipients with COVID-19. A database search of literature published between December 1, 2019 ... recipients with COVID-19 had a high prevalence of dyspnea and gastrointestinal symptoms ... Adverse clinical outcomes related to SARS-CoV-2 infection among liver transplant (LTx) recipients ...
| Abstract | Adverse clinical outcomes related to SARS-CoV-2 infection among liver transplant (LTx) recipients remain undefined. We performed a meta-analysis to determine the pooled prevalence of outcomes among hospitalized LTx recipients with COVID-19. A database search of literature published between December 1, 2019, and November 20, 2020, was performed per PRISMA guidelines. Twelve studies comprising 517 hospitalized LTx recipients with COVID-19 were analyzed. Common presenting symptoms were fever (71%), cough (62%), dyspnea (48%), and diarrhea (28%). Approximately 77% (95% CI, 61%-93%) of LTx recipients had a history of liver cirrhosis. The most prevalent comorbidities were hypertension (55%), diabetes (45%), and cardiac disease (21%). In-hospital mortality was 20% (95% CI, 13%-28%) and rose to 41% (95% CI, 19%-63%) (P < 0.00) with ICU admission. Additional subgroup analysis demonstrated a higher mortality risk in the elderly (>60-65 years) (OR 4.26; 95% CI, 2.14-8.49). There was no correlation in respect to sex or time since transplant. In summary, LTx recipients with COVID-19 had a high prevalence of dyspnea and gastrointestinal symptoms. In-hospital mortality was comparable to non-transplant populations with similar comorbidities but appeared to be less than what is reported elsewhere for cirrhotic patients (26%-40%). Importantly, the observed high case fatality in the elderly could be due to age-associated comorbidities. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Carcinoma, Hepatocellular/surgery ; Female ; Hospitalization ; Humans ; Liver Neoplasms/surgery ; Liver Transplantation ; Male ; Middle Aged ; Transplant Recipients |
| Language | English |
| Publishing date | 2021-02-25 |
| Publishing country | Denmark |
| Document type | Journal Article ; Meta-Analysis ; Systematic Review |
| ZDB-ID | 639001-8 |
| ISSN | 1399-0012 ; 0902-0063 |
| ISSN (online) | 1399-0012 |
| ISSN | 0902-0063 |
| DOI | 10.1111/ctr.14246 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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