Article ; Online: Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
2021 Volume 26, Issue 5
Abstract: Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR ... with confirmed seronegative status. After four months protection offered by prior infection against re-infection ... positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1 ...
| Abstract | Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; COVID-19/blood ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Serological Testing ; Disease Outbreaks/prevention & control ; Female ; Humans ; London ; Male ; Middle Aged ; Nursing Homes/statistics & numerical data ; Pandemics ; Reinfection/prevention & control ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Whole Genome Sequencing | |||||
| Chemical Substances | Antibodies, Viral | |||||
| Language | English | |||||
| Publishing date | 2021-02-04 | |||||
| Publishing country | Sweden | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1338803-4 | |||||
| ISSN | 1560-7917 ; 1025-496X | |||||
| ISSN (online) | 1560-7917 | |||||
| ISSN | 1025-496X | |||||
| DOI | 10.2807/1560-7917.ES.2021.26.5.2100092 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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