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Article ; Online: Scrub typhus: clinical, pathologic, and imaging findings.

Jeong, Yeon Joo / Kim, Suk / Wook, Yeh Dae / Lee, Jun Woo / Kim, Kun-Il / Lee, Sun Hee

Radiographics : a review publication of the Radiological Society of North America, Inc

2007  Volume 27, Issue 1, Page(s) 161–172

Abstract: ... gallbladder wall thickening, and lymphadenopathy. Although the severity of scrub typhus varies considerably ... of scrub typhus allow early diagnosis and timely initiation of appropriate therapy, and thereby may help reduce ... Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The main pathologic ...

Abstract Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The main pathologic change is focal or disseminated vasculitis caused by the destruction of endothelial cells and the perivascular infiltration of leukocytes. The diagnosis of scrub typhus is based on the patient's history of exposure, clinical features, and results of serologic testing. Regional and generalized lymphadenopathy is common. The pulmonary manifestations of scrub typhus include interstitial pneumonia, interstitial edema, and hemorrhage caused by vasculitis. Abdominal manifestations include splenomegaly, periportal edema, gallbladder wall thickening, and lymphadenopathy. Although the severity of scrub typhus varies considerably, involvement of the central nervous system is seen in almost all patients and can result in meningoencephalitis. A high degree of clinical suspicion and familiarity with the various radiologic manifestations of scrub typhus allow early diagnosis and timely initiation of appropriate therapy, and thereby may help reduce patient morbidity.
MeSH term(s) Diagnosis, Differential ; Humans ; Image Enhancement/methods ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Radiography ; Scrub Typhus/complications ; Scrub Typhus/diagnostic imaging ; Vasculitis/diagnostic imaging ; Vasculitis/etiology
Language English
Publishing date 2007-01
Publishing country United States
Document type Journal Article ; Review
ZDB-ID 603172-9
ISSN 1527-1323 ; 0271-5333
ISSN (online) 1527-1323
ISSN 0271-5333
DOI 10.1148/rg.271065074
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