Article: NADPH oxidase: recent evidence for its role in erectile dysfunction.
2007 Volume 10, Issue 1, Page(s) 6–13
Abstract: ... in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH ... disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED. ... Although it has become evident that increased ROS is associated with erectile dysfunction (ED), the sources of ROS ...
| Abstract | Important roles for reactive oxygen species (ROS) in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction (ED), the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED. |
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| MeSH term(s) | Aging ; Animals ; Diabetes Mellitus ; Erectile Dysfunction/enzymology ; Erectile Dysfunction/etiology ; Humans ; Hyperhomocysteinemia ; Hyperlipidemias ; Hypertension ; Male ; NADPH Oxidases/physiology ; Reactive Oxygen Species | |||||
| Chemical Substances | Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-) | |||||
| Language | English | |||||
| Publishing date | 2007-12-18 | |||||
| Publishing country | China | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 2075824-8 | |||||
| ISSN | 1745-7262 ; 1008-682X | |||||
| ISSN (online) | 1745-7262 | |||||
| ISSN | 1008-682X | |||||
| DOI | 10.1111/j.1745-7262.2008.00371.x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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