Article ; Online: Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
2021 Volume 591, Issue 7849, Page(s) 293–299
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-a new coronavirus that has led ...
| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-a new coronavirus that has led to a worldwide pandemic |
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| MeSH term(s) | Amino Acid Sequence ; Animals ; Antibodies, Neutralizing/immunology ; COVID-19/pathology ; COVID-19/physiopathology ; COVID-19/virology ; Cell Line ; Chlorocebus aethiops ; Cricetinae ; Female ; Furin/metabolism ; Humans ; Lung Diseases/pathology ; Lung Diseases/physiopathology ; Lung Diseases/virology ; Male ; Mice ; Mice, Transgenic ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutation ; Proteolysis ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Serine Endopeptidases/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Virus Replication/genetics | |||||||||||||||
| Chemical Substances | Antibodies, Neutralizing ; Mutant Proteins ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; Furin (EC 3.4.21.75) | |||||||||||||||
| Language | English | |||||||||||||||
| Publishing date | 2021-01-25 | |||||||||||||||
| Publishing country | England | |||||||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. | |||||||||||||||
| ZDB-ID | 120714-3 | |||||||||||||||
| ISSN | 1476-4687 ; 0028-0836 | |||||||||||||||
| ISSN (online) | 1476-4687 | |||||||||||||||
| ISSN | 0028-0836 | |||||||||||||||
| DOI | 10.1038/s41586-021-03237-4 | |||||||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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