LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Diagnosis of Mitral Valve Prolapse

    Ali Alenazy / Abdalla Eltayeb / Muteb K. Alotaibi / Muhammah Kashif Anwar / Norah Mulafikh / Mohammed Aladmawi / Olga Vriz

    Journal of Clinical Medicine, Vol 11, Iss 455, p

    Much More than Simple Prolapse. Multimodality Approach to Risk Stratification and Therapeutic Management

    2022  Volume 455

    Abstract: Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has ... stratification and treatment guidance. ... who experience this complication are in general young women, with thickened mitral leaflets or bileaflet prolapse ...

    Abstract Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has generally a benign course; however, recent findings suggested an association between MVP and complex arrhythmias and eventually cardiac arrest and for this reason, it is also called arrhythmogenic MVP. Subjects who experience this complication are in general young women, with thickened mitral leaflets or bileaflet prolapse not necessarily associated with severe mitral regurgitation (MR). The nature of the relation between MVP and cardiac arrest is not clearly understood. Actually, the challenging task is to find the cluster of prognostic factors including T-wave inversion, polymorphic premature ventricular contractions, bileaflet prolapse, MR severity, but most importantly, those parameters of hypercontractility, mitral annulus disjunction (MAD), and myocardial fibrosis using a multimodality approach. Transthoracic echocardiography is the first-line imaging modality for the diagnosis of MVP, but also for detecting MAD and hypercontractility, followed by cardiac magnetic resonance for tissue characterization and detection of myocardial and papillary muscle fibrosis, using either late gadolinium enhancement (at the basal segment of the inferolateral wall and papillary muscles) (macro-fibrosis), or diffuse fibrosis by T1 mapping (native and post contrast T1). Moreover, there are also preliminary data on positron emission tomography utilizing 18 F-fluorodeoxyglucose as a tool for providing evidence of early myocardial inflammation. The objective of this review article is to provide the clinician with an overview and a practical clinical approach to MVP for risk stratification and treatment guidance.
    Keywords mitral valve prolapse ; mitral annulus disjunction ; myocardial fibrosis ; complex ventricular arrhythmias ; cardiac magnetic resonance ; echocardiography ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Mitral valve prolapse: diagnosis, treatment and natural course.

    Jonkaitiene, Regina / Benetis, Rimantas / Ablonskyte-Dūdoniene, Rūta / Jurkevicius, Renaldas

    Medicina (Kaunas, Lithuania)

    2005  Volume 41, Issue 4, Page(s) 325–334

    Abstract: ... of mitral valve prolapse, complications and their frequency, treatment strategy in KUMHC, as well as to review the results ... surgical treatment for the patients with severe mitral regurgitation secondary to mitral valve prolapse. ... with primary mitral valve prolapse. Surgical treatment was applied in 44 (28.1%) of study patients ...

    Abstract This article analyzes data obtained from the medical records of the patients with primary mitral valve prolapse. The study population was the patients admitted to Kaunas University of Medicine Heart Center (KUMHC) between 1999 and 2003. The objective of our study was to analyze the natural course of mitral valve prolapse, complications and their frequency, treatment strategy in KUMHC, as well as to review the results of surgical treatment. We gathered data from the medical records of 160 patients and analyzed their age, medical history, complications, comorbidities, functional status and echocardiographic parameters. Patients who underwent mitral valve surgery were followed 7.9+/-8.4 months after procedure. On average, 32+/-14 patients with primary mitral valve prolapse were treated at KUMHC annually. Their mean age was 48.4+/-16.5 years, 44.4% of them were male. The most frequent complications of mitral valve prolapse were > or =II degrees mitral regurgitation (78.4%), various cardiac arrhythmias (68.1%) and heart failure of > or =II NYHA class (79%). Surgical treatment was recommended for 64 (40%) KUMHC patients with primary mitral valve prolapse. Surgical treatment was applied in 44 (28.1%) of study patients. The patients, who were recommended surgical treatment, were older (mean age 53.2+/-11.9 years, p<0.05) and predominantly male (62.5%, p<0.05) as compared to medically managed patients. The heart failure (62.5% had NYHA class III or IV), severe mitral regurgitation (95.3% had mitral regurgitation of > or =III degrees ) and worse left ventricle function (15% had ejection fraction of <50%) were more frequent in this group as compared to medically managed patients (all p<0.05). During the last five years the number of hospitalized patients with primary mitral valve prolapse increased 3.2 times, the number of mitral valve surgical procedures among these patients increased 2.8 times, and the number of mitral valve repair increased 15.8 times. 56.8% of patients had uncomplicated postoperative course. The most frequent postoperative complication was new arrhythmias and/or conduction disturbances. 1 patient died in early postoperative period. There was significant decrease in left ventricle and left atrium size and the severity of mitral regurgitation 2 to 6 months after mitral valve surgery. These positive changes remained during all study period. Taking in the consideration the large number of mitral valve repair procedures and good outcomes, the low postoperative mortality of the surgical mitral valve prolapse treatment in KUMHC, we can strongly recommend surgical treatment for the patients with severe mitral regurgitation secondary to mitral valve prolapse.
    MeSH term(s) Adult ; Age Factors ; Data Interpretation, Statistical ; Echocardiography ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/diagnosis ; Mitral Valve Prolapse/diagnostic imaging ; Mitral Valve Prolapse/physiopathology ; Mitral Valve Prolapse/surgery ; Postoperative Complications ; Stroke Volume ; Time Factors ; Treatment Outcome ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2005
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Diagnosis of Mitral Valve Prolapse: Much More than Simple Prolapse. Multimodality Approach to Risk Stratification and Therapeutic Management.

    Alenazy, Ali / Eltayeb, Abdalla / Alotaibi, Muteb K / Anwar, Muhammah Kashif / Mulafikh, Norah / Aladmawi, Mohammed / Vriz, Olga

    Journal of clinical medicine

    2022  Volume 11, Issue 2

    Abstract: Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has ... who experience this complication are in general young women, with thickened mitral leaflets or bileaflet prolapse ... bileaflet prolapse, MR severity, but most importantly, those parameters of hypercontractility, mitral ...

    Abstract Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has generally a benign course; however, recent findings suggested an association between MVP and complex arrhythmias and eventually cardiac arrest and for this reason, it is also called arrhythmogenic MVP. Subjects who experience this complication are in general young women, with thickened mitral leaflets or bileaflet prolapse not necessarily associated with severe mitral regurgitation (MR). The nature of the relation between MVP and cardiac arrest is not clearly understood. Actually, the challenging task is to find the cluster of prognostic factors including T-wave inversion, polymorphic premature ventricular contractions, bileaflet prolapse, MR severity, but most importantly, those parameters of hypercontractility, mitral annulus disjunction (MAD), and myocardial fibrosis using a multimodality approach. Transthoracic echocardiography is the first-line imaging modality for the diagnosis of MVP, but also for detecting MAD and hypercontractility, followed by cardiac magnetic resonance for tissue characterization and detection of myocardial and papillary muscle fibrosis, using either late gadolinium enhancement (at the basal segment of the inferolateral wall and papillary muscles) (macro-fibrosis), or diffuse fibrosis by T1 mapping (native and post contrast T1). Moreover, there are also preliminary data on positron emission tomography utilizing
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11020455
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Biology of mitral valve prolapse: the harvest is big, but the workers are few.

    Loardi, Claudia / Alamanni, Francesco / Trezzi, Matteo / Kassem, Samer / Cavallotti, Laura / Tremoli, Elena / Pacini, Davide / Parolari, Alessandro

    International journal of cardiology

    2011  Volume 151, Issue 2, Page(s) 129–135

    Abstract: Mitral valve prolapse (MVP) represents a common degenerative disease, often requiring surgery ... therapeutic strategies aimed at modifying or slackening MVP natural course in the early phases. ... If untreated, MVP with considerable valve incompetence can lead to cardiovascular and systemic complications ...

    Abstract Mitral valve prolapse (MVP) represents a common degenerative disease, often requiring surgery. If untreated, MVP with considerable valve incompetence can lead to cardiovascular and systemic complications causing substantial morbidity and mortality. In contrast with the wide knowledge concerning clinical and physiological features, currently available data regarding its molecular bases are very limited. We review current knowledge concerning MVP biological mechanisms, focusing on specific aspects of haemostasis, platelet function, oxidative stress, extracellular matrix remodeling and genomics. In particular, available evidence supports the role played by tissue remodeling processes in determining MVP onset and progression. Moreover, even if a consistent although controversial perturbation of haemostatic system and alterations of the oxidative stress equilibrium have been proposed to influence disease development, it is unknown whether these changes precede or follow MVP occurrence. Consequently, the complete knowledge of all the biochemical pathways involved are far from complete. In addition, changes in the regulation pattern of adrenergic and renin-angiotensin-aldosterone systems have been described in MVP syndrome, a condition characterized by the association of MVP with other peculiar neurological and general symptoms, but it is unknown whether these abnormalities are shared by "traditional" MVP. In conclusion, MVP is probably a multi-factorial process, and many aspects still need to be clarified. As surgery can only correct the damaged valve but not the underlying mechanisms, a more complete knowledge of the involved molecular pathways is necessary, as it may allow the discovery of targeted therapeutic strategies aimed at modifying or slackening MVP natural course in the early phases.
    MeSH term(s) Animals ; Blood Platelets/physiology ; Diagnostic Imaging/methods ; Disease Progression ; Extracellular Matrix/metabolism ; Hemostasis/physiology ; Humans ; Mitral Valve Prolapse/diagnosis ; Mitral Valve Prolapse/metabolism ; Mitral Valve Prolapse/physiopathology ; Oxidative Stress/physiology ; Prognosis ; Ventricular Function/physiology
    Language English
    Publishing date 2011-09-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2010.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top