Article ; Online: Innate and adaptive immune responses to SARS-CoV-2 in humans: relevance to acquired immunity and vaccine responses.
Clinical and experimental immunology
2021 Volume 204, Issue 3, Page(s) 310–320
Abstract: ... 19 infection. Information regarding innate and adaptive immune responses to the novel severe ... of patients infected with SARS-CoV-2 and the development of novel vaccines. In this paper, data on important ... innate immune responses are summarized, including cytokines, specifically interleukin (IL)-6 and complement, and potential ...
| Abstract | The factors responsible for the spectrum of coronavirus 19 (COVID-19) disease severity and the genesis and nature of protective immunity against COVID-19 remain elusive. Multiple studies have investigated the immune responses to COVID-19 in various populations, including those without evidence of COVID-19 infection. Information regarding innate and adaptive immune responses to the novel severe respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly. Data are accumulating defining disease phenotypes that aid in rational and informed development of new therapeutic approaches for the treatment of patients infected with SARS-CoV-2 and the development of novel vaccines. In this paper, data on important innate immune responses are summarized, including cytokines, specifically interleukin (IL)-6 and complement, and potential treatments are explored. Adaptive immune responses and derivative therapeutics such as monoclonal antibodies directed at spike proteins are also examined. Finally, data on real-time assessments of adaptive immune responses are explored, which include CD4 |
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| MeSH term(s) | Adaptive Immunity ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Humoral ; Immunity, Innate ; Interleukin-6/metabolism ; SARS-CoV-2/physiology ; T-Lymphocytes/immunology ; Vaccine Potency | |||||
| Chemical Substances | COVID-19 Vaccines ; Interleukin-6 | |||||
| Language | English | |||||
| Publishing date | 2021-03-04 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 218531-3 | |||||
| ISSN | 1365-2249 ; 0009-9104 ; 0964-2536 | |||||
| ISSN (online) | 1365-2249 | |||||
| ISSN | 0009-9104 ; 0964-2536 | |||||
| DOI | 10.1111/cei.13582 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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