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  1. Article ; Online: COVID-19 and the endothelium.

    Jung, F / Krüger-Genge, A / Franke, R P / Hufert, F / Küpper, J-H

    Clinical hemorheology and microcirculation

    2020  Volume 75, Issue 1, Page(s) 7–11

    Abstract: There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial ... in COVID-19 patients leading to venular as well as to arteriolar occlusions. ... system. Recent studies showed that this can lead to microcirculatory impairments and in consequence ...

    Abstract There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial system. Recent studies showed that this can lead to microcirculatory impairments and in consequence to functional disorders of all inner organs. The combination of endothelial dysfunction with a generalized inflammatory state and complement elements may together contribute to the overall pro-coagulative state described in COVID-19 patients leading to venular as well as to arteriolar occlusions.
    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/virology ; Humans ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-209007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 and the endothelium

    Jung, F / Krüger-Genge, A / Franke, R P / Hufert, F / Küpper, J-H

    Clin Hemorheol Microcirc

    Abstract: There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial ... in COVID-19 patients leading to venular as well as to arteriolar occlusions. ... system. Recent studies showed that this can lead to microcirculatory impairments and in consequence ...

    Abstract There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial system. Recent studies showed that this can lead to microcirculatory impairments and in consequence to functional disorders of all inner organs. The combination of endothelial dysfunction with a generalized inflammatory state and complement elements may together contribute to the overall pro-coagulative state described in COVID-19 patients leading to venular as well as to arteriolar occlusions.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612040
    Database COVID19

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  3. Article ; Online: COVID-19 and Dysfunctional Endothelium: The Mexican Scenario.

    Alvarado-Moreno, Jose Antonio / Majluf-Cruz, Abraham

    Archives of medical research

    2020  Volume 51, Issue 6, Page(s) 587–588

    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.05.004
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  4. Article ; Online: COVID-19 and Dysfunctional Endothelium

    Alvarado-Moreno, Jose Antonio / Majluf-Cruz, Abraham

    Archives of Medical Research

    The Mexican Scenario

    2020  Volume 51, Issue 6, Page(s) 587–588

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1156844-6
    ISSN 0188-4409 ; 0188-0128
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.05.004
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  6. Article ; Online: The Endothelium and COVID-19

    Isabelle Six / Nicolas Guillaume / Valentine Jacob / Romuald Mentaverri / Said Kamel / Agnès Boullier / Michel Slama

    International Journal of Molecular Sciences, Vol 23, Iss 6196, p

    An Increasingly Clear Link Brief Title: Endotheliopathy in COVID-19

    2022  Volume 6196

    Abstract: ... vesicles to the pathogenesis of COVID-19, and discuss therapeutic strategies that target the endothelium ... into the bloodstream. During COVID-19, however, endothelial cells are detached more rapidly, and do not regenerate ... responses mediated by the endothelium and nitric oxide production in particular, which results in greater ...

    Abstract The endothelium has a fundamental role in the cardiovascular complications of coronavirus disease 2019 (COVID-19). Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particularly affects endothelial cells. The virus binds to the angiotensin-converting enzyme 2 (ACE-2) receptor (present on type 2 alveolar cells, bronchial epithelial cells, and endothelial cells), and induces a cytokine storm. The cytokines tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 have particular effects on endothelial cells—leading to endothelial dysfunction, endothelial cell death, changes in tight junctions, and vascular hyperpermeability. Under normal conditions, apoptotic endothelial cells are removed into the bloodstream. During COVID-19, however, endothelial cells are detached more rapidly, and do not regenerate as effectively as usual. The loss of the endothelium on the luminal surface abolishes all of the vascular responses mediated by the endothelium and nitric oxide production in particular, which results in greater contractility. Moreover, circulating endothelial cells infected with SARS-CoV-2 act as vectors for viral dissemination by forming clusters that migrate into the circulation and reach distant organs. The cell clusters and the endothelial dysfunction might contribute to the various thromboembolic pathologies observed in COVID-19 by inducing the formation of intravascular microthrombi, as well as by triggering disseminated intravascular coagulation. Here, we review the contributions of endotheliopathy and endothelial-cell-derived extracellular vesicles to the pathogenesis of COVID-19, and discuss therapeutic strategies that target the endothelium in patients with COVID-19.
    Keywords COVID-19 ; SARS-CoV-2 ; endothelium ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Endothelium dysfunction and thrombosis in COVID-19 with type 2 diabetes.

    Li, Mengdi / Wu, Xiaoming / Shi, Jialan / Niu, Yumei

    Endocrine

    2023  Volume 82, Issue 1, Page(s) 15–27

    Abstract: ... of thrombotic complications, and longer duration of post-COVID-19 sequelae. This review provided a detailed ... of vaccines in the diabetic population, reduce the incidence of post-COVID-19 sequelae, and improve patient ... overview of the mechanisms underlying endothelial dysfunction in T2D patients with COVID-19 (including long ...

    Abstract SARS-CoV-2 can directly or indirectly damage endothelial cells. Endothelial injury, especially phosphatidylserine (PS) exposure on the outer membrane of cells, can more easily promote thrombosis. Type 2 diabetes(T2D) patients were more susceptible to COVID-19, they had more severe symptoms, higher risk of thrombotic complications, and longer duration of post-COVID-19 sequelae. This review provided a detailed overview of the mechanisms underlying endothelial dysfunction in T2D patients with COVID-19 (including long COVID), which may be influenced by hyperglycemia, hypoxia, and pro-inflammatory environments. The mechanisms of thrombosis in T2D patients with COVID-19 are also explored, particularly the effects of increased numbers of PS-exposing particles, blood cells, and endothelial cells on hypercoagulability. Given the high risk of thrombosis in T2D patients with COVID-19, early antithrombotic therapy can both minimize the impact of the disease on patients and maximize the chances of improvement, thereby alleviating patient suffering. We provided detailed guidance on antithrombotic drugs and dosages for mild, moderate, and severe patients, emphasizing that the optimal timing of thromboprophylaxis is a critical factor in influencing prognosis. Considering the potential interactions between antidiabetic, anticoagulant, and antiviral drugs, we proposed practical and comprehensive management recommendations to supplement the incomplete efficacy of vaccines in the diabetic population, reduce the incidence of post-COVID-19 sequelae, and improve patient quality of life.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Anticoagulants/therapeutic use ; Post-Acute COVID-19 Syndrome ; Endothelial Cells ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Quality of Life ; Venous Thromboembolism/complications ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Thrombosis/epidemiology ; Thrombosis/etiology ; Thrombosis/drug therapy ; Endothelium
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03439-y
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  8. Article ; Online: COVID-19: Precision Medicine and Vascular Endothelium.

    Tricarico, Gerardo / Travagli, Valter

    Mayo Clinic proceedings

    2021  Volume 96, Issue 6, Page(s) 1672

    MeSH term(s) COVID-19 ; Endothelium, Vascular ; Humans ; Precision Medicine ; SARS-CoV-2
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.04.004
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  9. Article ; Online: Tissue Factor and COVID-19 Associated Thrombosis.

    Mackman, Nigel

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 3, Page(s) 523–529

    Abstract: Microbial infections activate the innate and adaptive immune systems. ...

    Abstract Microbial infections activate the innate and adaptive immune systems.
    MeSH term(s) Humans ; Thromboplastin ; COVID-19/complications ; Receptors, Pattern Recognition ; Cytokines/metabolism ; Immunity, Innate
    Chemical Substances Thromboplastin (9035-58-9) ; Receptors, Pattern Recognition ; Cytokines
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.320144
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  10. Article ; Online: The role of platelets, neutrophils and endothelium in COVID-19 infection.

    Falcinelli, E / Petito, E / Gresele, P

    Expert review of hematology

    2022  Volume 15, Issue 8, Page(s) 727–745

    Abstract: ... complications of COVID-19 patients, and the current and future therapeutic approaches targeting these cell types ... of the thrombotic complications and of the adverse evolution of COVID-19. Both the direct interaction with the virus ... for the prevention and treatment of COVID-19-associated thrombosis, it acts downstream of the cascade of events ...

    Abstract Introduction: COVID-19 is associated to an increased risk of thrombosis, as a result of a complex process that involves the activation of vascular and circulating cells, the release of soluble inflammatory and thrombotic mediators and blood clotting activation.
    Areas covered: This article reviews the pathophysiological role of platelets, neutrophils, and the endothelium, and of their interactions, in the thrombotic complications of COVID-19 patients, and the current and future therapeutic approaches targeting these cell types.
    Expert opinion: Virus-induced platelet, neutrophil, and endothelial cell changes are crucial triggers of the thrombotic complications and of the adverse evolution of COVID-19. Both the direct interaction with the virus and the associated cytokine storm concur to trigger cell activation in a classical thromboinflammatory vicious circle. Although heparin has proven to be an effective prophylactic and therapeutic weapon for the prevention and treatment of COVID-19-associated thrombosis, it acts downstream of the cascade of events triggered by SARS-CoV-2. The identification of specific molecular targets interrupting the thromboinflammatory cascade upstream, and more specifically acting either on the interaction of SARS-CoV-2 with blood and vascular cells or on the specific signaling mechanisms associated with their COVID-19-associated activation, might theoretically offer greater protection with potentially lesser side effects.
    MeSH term(s) Blood Platelets/metabolism ; COVID-19/complications ; Endothelium/metabolism ; Humans ; Neutrophils/metabolism ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/metabolism
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2022.2110061
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