Article: Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP).
Journal of thermal analysis and calorimetry
2021 Volume 147, Issue 11, Page(s) 6337–6348
Abstract: ... bilayer behavior due to the presence of PEGylated at varying concentrations and sizes, and the encapsulated HPPH ... In this work, we demonstrate the enhanced thermal and steric stability of lipid-based formulations ... in the presence of encapsulated HPPH that have demonstrated potential cancer applications in previously presented ...
| Abstract | In this work, we demonstrate the enhanced thermal and steric stability of lipid-based formulations in the presence of encapsulated HPPH that have demonstrated potential cancer applications in previously presented in vivo studies. Differential scanning calorimeter (DSC) was used to study the phase transitions, and domain formations, and to qualify the thermodynamic properties associated with change in lipid bilayer behavior due to the presence of PEGylated at varying concentrations and sizes, and the encapsulated HPPH molecules. Thermal instability was quantified by dramatic changes in calculated enthalpy, and the shape of the melting peak or calculated half width of melting peak. This systematic study focused on understanding the effects of varying molecular mass and concentrations of PEG polymers in the photopolymerizable lipid DC |
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| Language | English |
| Publishing date | 2021-06-26 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2017304-0 |
| ISSN | 1572-8943 ; 1588-2926 ; 1388-6150 ; 1418-2874 |
| ISSN (online) | 1572-8943 ; 1588-2926 |
| ISSN | 1388-6150 ; 1418-2874 |
| DOI | 10.1007/s10973-021-10929-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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