Article ; Online: Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production.
2018 Volume 67, Issue 1, Page(s) 68–77
Abstract: ... that the presence of the gliotic scar produced by reactive astrocytes play a critical role in these detrimental ... underlying impaired neuronal function are not fully understood, but evidence is accumulating ... Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS ...
| Abstract | Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS), characterized by inflammation-mediated demyelination, axonal injury and neurodegeneration. The mechanisms underlying impaired neuronal function are not fully understood, but evidence is accumulating that the presence of the gliotic scar produced by reactive astrocytes play a critical role in these detrimental processes. Here, we identified astrocytic Transient Receptor Potential cation channel, subfamily M, member 7 (TRPM7), a Ca |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Animals ; Astrocytes/metabolism ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/biosynthesis ; Chondroitin Sulfate Proteoglycans/genetics ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/genetics ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Neurons/metabolism ; Neurons/pathology ; Protein-Serine-Threonine Kinases/biosynthesis ; Protein-Serine-Threonine Kinases/genetics ; Rats ; TRPM Cation Channels/biosynthesis ; TRPM Cation Channels/genetics | |||||
| Chemical Substances | Chondroitin Sulfate Proteoglycans ; TRPM Cation Channels ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) | |||||
| Language | English | |||||
| Publishing date | 2018-11-19 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 639414-0 | |||||
| ISSN | 1098-1136 ; 0894-1491 | |||||
| ISSN (online) | 1098-1136 | |||||
| ISSN | 0894-1491 | |||||
| DOI | 10.1002/glia.23526 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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