Article ; Online: Penicillin Allergy Label Increases Risk of Worse Clinical Outcomes in COVID-19.
The journal of allergy and clinical immunology. In practice
2021 Volume 9, Issue 10, Page(s) 3629–3637.e2
Abstract: ... yielded similar results.: Conclusions: Penicillin allergic patients have higher risk for worse COVID-19 ... Several comorbidities are associated with worse clinical outcomes. Antibiotic use is common in COVID-19 and penicillin ... To investigate the impact of PCN allergy label on COVID-19 outcomes.: Methods: For this retrospective ...
| Abstract | Background: Coronavirus disease-2019 (COVID-19) ranges from asymptomatic to severe. Several comorbidities are associated with worse clinical outcomes. Antibiotic use is common in COVID-19 and penicillin (PCN) allergy can affect antibiotic choice and may influence COVID-19 outcomes. Objective: To investigate the impact of PCN allergy label on COVID-19 outcomes. Methods: For this retrospective, cohort study, a Web-based tool for population cohort research, TriNetX, was used to identify adult COVID-19 patients with and without PCN allergy label. The two cohorts were matched using 1:1 propensity score matching for baseline demographics and conditions associated with risk for severe COVID-19. The 30-day risks for hospitalization, acute respiratory failure, intensive care unit requirement, mechanical ventilation requirement, and mortality were then compared between groups. Because bacterial infection can drive alternative antibiotic regimens, additional analyses focused on patients without bacterial infection. Results: After propensity score matching, each cohort consisted of 13,183 patients. COVID-19 patients with PCN allergy had higher risks for hospitalization (risk ratio [RR] = 1.46; 95% confidence interval [CI], 1.41-1.52) acute respiratory failure (RR = 1.25; 95% CI, 1.19-1.31), intensive care unit requirement (RR = 1.20; 95% CI, 1.08-1.34), and mechanical ventilation (RR = 1.17; 95% CI 1.03-1.32) compared with patients without PCN allergy; however, there was no mortality difference (RR = 1.09; 95% CI, 0.96-1.23). Although the bacterial infection risk was higher in PCN allergic COVID-19 patients, exclusion of patients with bacterial infections yielded similar results. Conclusions: Penicillin allergic patients have higher risk for worse COVID-19 outcomes and should be considered for risk mitigation strategies. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Adult ; COVID-19 ; Cohort Studies ; Drug Hypersensitivity/epidemiology ; Humans ; Penicillins ; Retrospective Studies ; SARS-CoV-2 | |||||
| Chemical Substances | Penicillins | |||||
| Language | English | |||||
| Publishing date | 2021-07-19 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural | |||||
| ZDB-ID | 2843237-X | |||||
| ISSN | 2213-2201 ; 2213-2198 | |||||
| ISSN (online) | 2213-2201 | |||||
| ISSN | 2213-2198 | |||||
| DOI | 10.1016/j.jaip.2021.06.054 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 7086: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.