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  1. Article: Mortality Rates of Coronavirus Disease 2019 (COVID-19) Caused by the Novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).

    Kandi, Venkataramana / Thungaturthi, Sudhakar / Vadakedath, Sabitha / Gundu, Rajkumar / Mohapatra, Ranjan K

    Cureus

    2021  Volume 13, Issue 3, Page(s) e14081

    Abstract: ... the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. This study, based on good ... COVID-19) is a measure of its severity. However, without statistical data, one cannot understand ... rates (IFRs) and case-fatality rates (CFRs) in various countries and regions of the world. Methods COVID ...

    Abstract Background The significance of the global prevalence and incidence of coronavirusdisease 2019 (COVID-19) is a measure of its severity. However, without statistical data, one cannot understand the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. This study, based on good data, enables us to know how the disease is spreading, what impact the pandemic has on the lives of people around the world, and whether the countermeasures that countries have been taking are successful for controlling and preventing the disease. Therefore, this study is undertaken to estimate the infection fatality rates (IFRs) and case-fatality rates (CFRs) in various countries and regions of the world. Methods COVID-19-related data were collected from various countries belonging to different World Bank categories based on economies (low-income, low-middle income, upper-middle income, and high-income countries) and the World Health Organization's (WHO's) regional classification of countries (the Americas, European, African, South-East Asia, Eastern Mediterranean, and Western Pacific regions). The data were collected from the WHO's dedicated website on COVID-19, and statistical methods like mean, standard deviation, p-value, and percentages were used to calculate the IFR and CFR. Results Mexico (8.94%) reported the highest IFR among all the countries. The low-income countries reported increased IFR (2.46±1.91) as compared to the other groups. The European region (7.3%) and the American region (5.3%) recorded the highest CFRs. The South-East Asian region reported the lowest CFR (1.1%). Conclusions The low-income group countries showed higher rates of IFR and lower CFRs. Lower IFRs and increased CFRs were noted among the high-income group countries and the American and European regions respectively. The varied IFRs and CFRs could be attributed to multiple factors that include climatic conditions, living environments, age, sex, comorbidities, among others.
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.14081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mortality and Associated Factors in Patients with COVID-19: Cross-Sectional Study.

    Carvalho, Vergílio Pereira / Pontes, João Paulo Jordão / Neto, Demócrito Ribeiro de Brito / Borges, Celso Eduardo Rezende / Campos, Gisele Ribeiro Londe / Ribeiro, Hugo Leonardo Shigenaga / Amaral, Waldemar Naves do

    Vaccines

    2022  Volume 11, Issue 1

    Abstract: The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly virulent and ... causes coronavirus disease 2019 (COVID-19), resulting in high morbidity and mortality mainly associated ... with severe acute respiratory syndrome (SARS) at a university hospital in the Central—West region of Brazil. This retrospective ...

    Abstract The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly virulent and causes coronavirus disease 2019 (COVID-19), resulting in high morbidity and mortality mainly associated with pulmonary complications. Because this virus is highly transmissible, it was quickly spread globally, resulting in COVID-19 being declared as a pandemic. This study aimed to analyze the prevalence of mortality and the factors related to mortality due to COVID-19 in patients with severe acute respiratory syndrome (SARS) at a university hospital in the Central—West region of Brazil. This retrospective cross-sectional study was based on an analysis of the medical records of patients with SARS aged >18 years and admitted to an intensive care unit due to COVID-19 with the requirement of invasive mechanical ventilation. Hospital death was considered as an outcome variable in this study. Moreover, demographic and lifestyle-related variables as well as the therapeutic measures used during the hospital stay were recorded and correlated with the death outcome. After excluding 188 medical records, 397 were analyzed. Most of the participants were men (59.7%), and the mortality rate in patients with SARS due to COVID-19 was 46.1%. Multiple regression analysis indicated that the independent factors associated with mortality in patients with SARS due to COVID-19 were the age of >60 years (p < 0.001) and the use of azithromycin (p = 0.012). Protective factors for mortality were considered as not having the following diseases: hyperthyroidism, asthma, hepatic inheritance, and not being a smoker. The mortality rate in patients with SARS due to COVID-19 was associated with older age and the use of azithromycin.
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19: Why Has the Mortality Rate Declined?

    Preskorn, Sheldon H

    Journal of psychiatric practice

    2020  Volume 26, Issue 5, Page(s) 394–399

    Abstract: ... Coronavirus-2 (SARS-CoV-2) which causes COVID-19 at the beginning of the pandemic because it is a novel human ... This article explains how the mortality rate of an illness such as Coronavirus Disease 2019 (COVID ... with the SARS-CoV-2 (or COVID-19) pandemic. ...

    Abstract This article explains how the mortality rate of an illness such as Coronavirus Disease 2019 (COVID-19) is calculated as well as how the definition of what is a "case" has changed from the earliest days of the pandemic to now. Many factors were not known about The Sudden Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) which causes COVID-19 at the beginning of the pandemic because it is a novel human pathogen. One key factor that was not known in the earliest days of the pandemic was that many patients are either asymptomatic or have symptoms so mild that they may not seek medical attention and hence these patients would not be identified as a "case" if that term is defined as being sufficiently symptomatic to be seeking medical attention. Cases in the earliest days of the pandemic were defined as based on having symptoms (eg, fever, cough, respiratory distress) after ruling out other possible causes. Cases now are defined by tests confirming that the person is shedding the SARS-CoV-2 (ie, a laboratory vs. a symptomatic diagnosis). The mortality rate of this virus dropped as a function of this change. On the basis of the results of an unintended, naturalistic experiment on an expeditionary cruise in March of 2020, there was more than a 5-fold drop in the calculated mortality rate due to this definitional change in what constituted a case. This column explains this issue and discusses its implications for effectively dealing with the SARS-CoV-2 (or COVID-19) pandemic.
    MeSH term(s) Betacoronavirus ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Testing ; Clinical Laboratory Techniques/statistics & numerical data ; Communicable Disease Control/instrumentation ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Transmission, Infectious/prevention & control ; Humans ; Masks ; Mortality/trends ; Pandemics/prevention & control ; Physical Distancing ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2022726-7
    ISSN 1538-1145 ; 1527-4160
    ISSN (online) 1538-1145
    ISSN 1527-4160
    DOI 10.1097/PRA.0000000000000494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan.

    Zheng, Ting / Liu, Xinxin / Wei, Yingying / Li, Xinlu / Zheng, Bing / Gong, Quan / Dong, Lingli / Zhong, Jixin

    Mediators of inflammation

    2021  Volume 2021, Page(s) 6687412

    Abstract: Background: Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited ... predictors of COVID-19 mortality and risk factors for hyperinflammation in COVID-19.: Methods ...

    Abstract Background: Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited effective medications approved for this deadly disease.
    Objective: To investigate the potential predictors of COVID-19 mortality and risk factors for hyperinflammation in COVID-19.
    Methods: Retrospective analysis was carried out in 1,149 patients diagnosed with COVID-19 in Tongji Hospital, Wuhan, China, from 1/13/2020 to 3/15/2020.
    Results: We found significant differences in the rates of hyperuricemia (OR: 3.17, 95% CI: 2.13-4.70;
    Conclusions: Our results suggest that uric acid, the end product of purine metabolism, was increased in deceased patients with COVID-19. In addition, the serum level of uric acid was positively associated with inflammatory markers. Uric acid lowering therapy in COVID-19 patients with hyperuricemia may be beneficial.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; COVID-19/blood ; COVID-19/immunology ; COVID-19/mortality ; China/epidemiology ; Cytokines/blood ; Female ; Humans ; Hyperuricemia/blood ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Inflammation Mediators/blood ; Interleukin-6/blood ; Male ; Middle Aged ; Pandemics ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Uric Acid/blood
    Chemical Substances Biomarkers ; Cytokines ; IL6 protein, human ; Inflammation Mediators ; Interleukin-6 ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2021/6687412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease.

    Mamishi, Setareh / Pourakbari, Babak / Mehdizadeh, Mehrzad / Navaeian, Amene / Eshaghi, Hamid / Yaghmaei, Bahareh / Hosseinpour Sadeghi, Reihaneh / Poormohammadi, Shiva / Mahmoudieh, Yasmine / Mahmoudi, Shima

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 382

    Abstract: Background: The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS ... disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well ... with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological ...

    Abstract Background: The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases.
    Methods: This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2.
    Results: Among the 262 patients with suspected COVID-19, 142 confirmed COVID-19 cases were included in the study. A total of 11 children were diagnosed as MIS-C. The majority of the cases with MIS-C were male, (n = 9, 82%) which is significantly higher than children (n = 61, 47%) with acute COVID-19 (P = 0.03). Fifty patients (35%) were shown to have a more severe form of COVID-19. Ninety percent of the cases (n = 45) with severe COVID-19 had comorbidities that was significantly higher than cases with non-severe or mild disease (n = 41, 45%; P < 0.0001). A mortality rate of 10% was reported (n = 14). Ninety-three percent of the deceased cases (n = 13) had comorbidities that were significantly higher than discharged patients (n = 73, 57%; P = 0.009).
    Conclusion: The increasing number of children with severe COVID-19 is cause for great concern. Underlying diseases, mainly cardiovascular diseases, cancer, and malignancies, are associated with greater risk of development of severe COVID-19 and even death in children. On the other hand, pediatric patients with MIS-C usually develop a milder form of the disease. However, evaluation specific immunological responses in children to explore the delayed inflammatory syndrome are highly recommended.
    MeSH term(s) Adolescent ; COVID-19/complications ; Child ; Disease Outbreaks ; Female ; Humans ; Iran/epidemiology ; Male ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/epidemiology
    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07200-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Statistical data analysis of risk factor associated with mortality rate by COVID-19 pandemic in India.

    Halder, Bijay / Bandyopadhyay, Jatisankar / Banik, Papiya

    Modeling earth systems and environment

    2021  Volume 8, Issue 1, Page(s) 511–521

    Abstract: The coronavirus is an infection caused by severe acute respiratory syndrome (SARS) coronavirus ... known as SARS-CoV-2. It was first determined in Wuhan, China in December 2019. WHO named this virus ... as COVID-19. Virologist says that COVID-19 is similar to SARS and MARS virus. This deadly disease affected ...

    Abstract The coronavirus is an infection caused by severe acute respiratory syndrome (SARS) coronavirus, known as SARS-CoV-2. It was first determined in Wuhan, China in December 2019. WHO named this virus as COVID-19. Virologist says that COVID-19 is similar to SARS and MARS virus. This deadly disease affected worldwide economically, hammering people lifestyle and also the environmental condition. After a few months, there is no vaccine to build the barricade between this virus and life. Many countries have tried to improve the methodology to control the disease and also the actual vaccine for coronavirus but not yet successful. Rapid testing, quarantine and social distancing slow down the social and economic movement. Although India, as one of the largest populated country, takes some respectable initiative after the pandemic of the novel coronavirus. According to WHO 24th May 2020 report, total 131,868 confirmed cases and killed over 3867 people by this COVID-19 pandemic. Indian government takes the initiative like janta curfew, lockdown all over the country. The main focus or aim of this study is to find the mortality rate and the recovered people at the fourth phase of lockdown, but the infected graph is daily increased in India. In the relation between active cases and the death cases, the
    Language English
    Publishing date 2021-01-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821317-8
    ISSN 2363-6211 ; 2363-6203
    ISSN (online) 2363-6211
    ISSN 2363-6203
    DOI 10.1007/s40808-021-01118-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical Predictors of COVID-19 Mortality Among Patients in Intensive Care Units: A Retrospective Study.

    Al Mutair, Abbas / Al Mutairi, Alya / Zaidi, Abdul Rehman Zia / Salih, Samer / Alhumaid, Saad / Rabaan, Ali A / Al-Omari, Awad

    International journal of general medicine

    2021  Volume 14, Page(s) 3719–3728

    Abstract: ... severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been spreading rapidly worldwide within just a few months ... Objective: The ongoing pandemic of the coronavirus disease 2019 (COVID-19), which originated ... from Wuhan, China, has been identified to be caused by the novel beta coronavirus ...

    Abstract Objective: The ongoing pandemic of the coronavirus disease 2019 (COVID-19), which originated from Wuhan, China, has been identified to be caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been spreading rapidly worldwide within just a few months. Our aims were to analyze clinical and laboratory abnormalities in ICU patients with COVID-19, in order to define which predictors can distinguish between those who are at higher risk of developing fatal versus non-fatal forms of the disease.
    Methods: A descriptive cross-sectional survey was used; demographics, comorbidities, symptoms, laboratory parameters at ICU admission, and clinical outcomes for the adult patients admitted to ICU were collected from five hospitals in Saudi Arabia.
    Results: A total of 86 patients with COVID-19 admitted in ICU, 50 patients died, 23 recovered, and 13 were still admitted, with a mortality rate of 58.1%. Septic shock (OR (95% CI): 58.1 (5.97-7812.8), p < 0.001) and acute kidney injury (AKI) (OR (95% CI): 7.279 (1.191-65.43), p = 0.032) had a significant impact on mortality. Cox proportional-hazards regression analysis revealed that septic shock (HR (95% CI): 9.502 (2.958-30.524), p < 0.001) and neutrophil count (HR (95% CI): 1.053 (1.023-1.085), p < 0.001) were significant predictors for mortality.
    Conclusion: Septic shock, AKI, and high neutrophil count were found to be predictive of death in these patients. Further studies are needed to aid efficient recognition and management of severe COVID-19 patients in our population. .
    Language English
    Publishing date 2021-07-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S313757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Out-Of-Hospital Cardiac Arrest during the Coronavirus Disease 2019 (COVID-19) Pandemic in Brazil: The Hidden Mortality.

    Mesquita, Claudio Tinoco

    Arquivos brasileiros de cardiologia

    2021  Volume 116, Issue 2, Page(s) 272–274

    Abstract: ... COVID-19), caused by a beta coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV ... of out-of-hospital cardiac arrest during the Coronavirus disease 2019 (COVID-19) pandemic in the city ... The world changed in just a few months after the emergence of the novel coronavirus disease 2019 ...

    Title translation Parada Cardiorrespiratória Extra-Hospitalar durante a Pandemia da Doença por Coronavírus 2019 (COVID-19) no Brasil: A Mortalidade Oculta.
    Abstract The world changed in just a few months after the emergence of the novel coronavirus disease 2019 (COVID-19), caused by a beta coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Brazil currently has the world's second-highest COVID-19 death toll, second only to the USA. The COVID-19 pandemic is spreading fast in the world with more than 181 countries affected. This editorial refers to the article published in Arquivos Brasileiros de Cardiologia: "Increase in home deaths due to cardiorespiratory arrest in times of COVID-19 pandemic."1 Their main results show a gradual increase in the rate of out-of-hospital cardiac arrest during the Coronavirus disease 2019 (COVID-19) pandemic in the city of Belo Horizonte, Minas Gerais, Brazil. Their data demonstrate a proportional increase of 33% of home deaths in March 2020 compared to previous periods. Their study is the first Brazilian paper to demonstrate the same trend observed in other countries.
    MeSH term(s) Brazil/epidemiology ; COVID-19 ; Humans ; Out-of-Hospital Cardiac Arrest ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-02-24
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20210041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical Predictors of COVID-19 Mortality Among Patients in Intensive Care Units

    Al Mutair A / Al Mutairi A / Zaidi ARZ / Salih S / Alhumaid S / Rabaan AA / Al-Omari A

    International Journal of General Medicine, Vol Volume 14, Pp 3719-

    A Retrospective Study

    2021  Volume 3728

    Abstract: ... coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been spreading rapidly ... 2019 (COVID-19), which originated from Wuhan, China, has been identified to be caused by the novel beta ... Al Mutairi Email amutairi@taibahu.edu.saObjective: The ongoing pandemic of the coronavirus disease ...

    Abstract Abbas Al Mutair,1– 3 Alya Al Mutairi,4 Abdul Rehman Zia Zaidi,5,6 Samer Salih,5 Saad Alhumaid,7 Ali A Rabaan,8 Awad Al-Omari5,6 1Research Center, Almoosa Specialist Hospital, Al-Ahsa, 31982, Saudi Arabia; 2Research Center, College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh, Saudi Arabia; 3School of Nursing, University of Wollongong, Wollongong, Australia; 4Department of Mathematics, Faculty of Science, Taibah University, Medina, 54321, Saudi Arabia; 5Research Center, Dr. Sulaiman Al Habib Medical Group, Riyadh, 12214, Saudi Arabia; 6College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; 7Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa, Saudi Arabia; 8Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi ArabiaCorrespondence: Alya Al Mutairi Email amutairi@taibahu.edu.saObjective: The ongoing pandemic of the coronavirus disease 2019 (COVID-19), which originated from Wuhan, China, has been identified to be caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been spreading rapidly worldwide within just a few months. Our aims were to analyze clinical and laboratory abnormalities in ICU patients with COVID-19, in order to define which predictors can distinguish between those who are at higher risk of developing fatal versus non-fatal forms of the disease.Methods: A descriptive cross-sectional survey was used; demographics, comorbidities, symptoms, laboratory parameters at ICU admission, and clinical outcomes for the adult patients admitted to ICU were collected from five hospitals in Saudi Arabia.Results: A total of 86 patients with COVID-19 admitted in ICU, 50 patients died, 23 recovered, and 13 were still admitted, with a mortality rate of 58.1%. Septic shock (OR (95% CI): 58.1 (5.97– 7812.8), p < 0.001) and acute kidney injury (AKI) (OR (95% CI): 7.279 (1.191– 65.43), p = 0.032) had a significant impact on mortality. Cox proportional-hazards regression ...
    Keywords covid-19 ; severe acute respiratory syndrome coronavirus 2 ; intensive care units ; saudi arabia ; mortality ; Medicine (General) ; R5-920
    Subject code 610 ; 310
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Effect of COVID-19 on Serum Activity of Liver Enzymes: Is This Associated with Severity and Mortality Rate?

    Alavian, Seyed Ehsan / Mofidi, Mohammad / Shahabipour, Fahimeh

    Ibnosina Journal of Medicine and Biomedical Sciences

    2022  Volume 14, Issue 03, Page(s) 86–93

    Abstract: ... coronavirus known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease raises ... Introduction: Coronavirus disease 2019 (COVID-19) is a viral infection caused by a novel ... of SARS-CoV-2, abnormalities of liver enzyme tests were commonly observed in patients with COVID-19 ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a viral infection caused by a novel coronavirus known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease raises an enormous public health challenge for the international community. Liver enzymes have been reported to be frequently elevated in hospitalized patients with severe COVID-19 disease.
    Materials and Methods: This article is a narrative review of abnormal liver tests and liver injury as a manifestation of progression to severe pneumonia. We collected data from the PubMed database (National Library of Medicine, Bethesda, Maryland, United States). We used the search term “abnormal liver test” and relevant records were measured. The review article was organized thematically.
    Results: This narrative review aims to summarize the available clinical data on abnormal liver enzymes in coronavirus infection and its association with the risk of mortality, severer pneumonia, and systemic inflammation. Some clinical studies refer to abnormal liver tests and liver injury as a manifestation of progression to severe pneumonia. Recent research verified the relationship between hepatic liver enzyme activities and liver damage in patients with COVID-19, which suggested that it might reflect the infection severity and the mortality risk. Thus, this review investigated the correlation between liver serum enzymes level and the severity of COVID-19 patients, by reviewing investigating the relationship between the illness severity in COVID-19 patients with abnormal liver tests, liver pathology, and markers of inflammation.
    Conclusion: In the current pandemic of SARS-CoV-2, abnormalities of liver enzyme tests were commonly observed in patients with COVID-19. However, because of multiorgan damages that observed in COVID-19 patients, various issues should be considered such as the pathology and pathophysiology of the liver tissue, especially on the activation process of the immune response and cytokine storm to prevent the severity of the disease.
    Keywords COVID-19 ; liver enzyme ; coronavirus ; liver injury ; mortality
    Language English
    Publishing date 2022-09-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2585341-7
    ISSN 1947-489X ; 1947-489X
    ISSN (online) 1947-489X
    ISSN 1947-489X
    DOI 10.1055/s-0042-1759739
    Database Thieme publisher's database

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