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Article: Dietary restriction of amino acids for Cancer therapy.

Kang, Jian-Sheng

Nutrition & metabolism

2020 Volume 17, Page(s) 20

Abstract: ... might have the value and potential for cancer prevention or therapy. Moreover, dietary supplements were also ... proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are ... functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest ...

Abstract	Biosyntheses of proteins, nucleotides and fatty acids, are essential for the malignant proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are potential strategies for cancer interventions. Meanwhile, dietary strategies are popular among cancer patients. However, there is still lacking solid rationale to clarify what is the best strategy, why and how it is. Here, integrated analyses and comprehensive summaries for the abundances, signalling and functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest that, intermittent dietary lysine restriction with normal maize as an intermittent staple food for days or weeks, might have the value and potential for cancer prevention or therapy. Moreover, dietary supplements were also discussed for cancer cachexia including dietary immunomodulatory.
Keywords	covid19
Language	English
Publishing date	2020-03-14
Publishing country	England
Document type	Journal Article ; Review
ISSN	1743-7075
ISSN	1743-7075
DOI	10.1186/s12986-020-00439-x
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Book ; Online: Dietary Restriction of Amino Acids for Cancer Therapy

Kang, Jian-Sheng

2020

Abstract: ... staple food for days or weeks, might have the value and potential for cancer prevention or therapy. Moreover ... proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are ... functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest ...

Abstract	Biosyntheses of proteins, nucleotides and fatty acids, are essential for the malignant proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are potential strategies for cancer interventions. Meanwhile, dietary strategies are popular among cancer patients. However, there is still lacking solid rationale to clarify what is the best strategy, why and how it is. Here, integrated analyses and comprehensive summaries for the abundances, signalling and functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest that, intermittent fasting or intermittent dietary lysine restriction with normal maize as an intermittent staple food for days or weeks, might have the value and potential for cancer prevention or therapy. Moreover, dietary supplements were also discussed for cancer cachexia including dietary immunomodulatory. Comment: 4 figures
Keywords	Quantitative Biology - Biomolecules ; Quantitative Biology - Molecular Networks ; Quantitative Biology - Subcellular Processes
Subject code	610
Publishing date	2020-01-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dietary approaches for exploiting metabolic vulnerabilities in cancer.

Menyhárt, Otília / Győrffy, Balázs

Biochimica et biophysica acta. Reviews on cancer

2023 Volume 1879, Issue 2, Page(s) 189062

Abstract: ... We examine popular dietary approaches used as adjuvants to anticancer therapies, encompassing ... in their metabolic dependencies and preferred energy sources and can be addicted to glucose, fructose, amino acids ... Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to prevent and ...

Abstract	Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to prevent and treat cancer. Changes in diet impact circulating nutrient levels in the plasma and the tumor microenvironment, and preclinical studies suggest that dietary approaches, including caloric and nutrient restrictions, can modulate tumor initiation, progression, and metastasis. Cancers are heterogeneous in their metabolic dependencies and preferred energy sources and can be addicted to glucose, fructose, amino acids, or lipids for survival and growth. This dependence is influenced by tumor type, anatomical location, tissue of origin, aberrant signaling, and the microenvironment. This review summarizes nutrient dependencies and the related signaling pathway activations that provide targets for nutritional interventions. We examine popular dietary approaches used as adjuvants to anticancer therapies, encompassing caloric restrictions, including time-restricted feeding, intermittent fasting, fasting-mimicking diets (FMDs), and nutrient restrictions, notably the ketogenic diet. Despite promising results, much of the knowledge on dietary restrictions comes from in vitro and animal studies, which may not accurately reflect real-life situations. Further research is needed to determine the optimal duration, timing, safety, and efficacy of dietary restrictions for different cancers and treatments. In addition, well-designed human trials are necessary to establish the link between specific metabolic vulnerabilities and targeted dietary interventions. However, low patient compliance in clinical trials remains a significant challenge.
MeSH term(s)	Animals ; Humans ; Diet ; Fasting ; Caloric Restriction ; Neoplasms/prevention & control ; Glucose ; Tumor Microenvironment
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-12-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2023.189062
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Article: Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy.

Orillion, Ashley / Damayanti, Nur P / Shen, Li / Adelaiye-Ogala, Remi / Affronti, Hayley / Elbanna, May / Chintala, Sreenivasulu / Ciesielski, Michael / Fontana, Luigi / Kao, Chinghai / Elzey, Bennett D / Ratliff, Timothy L / Nelson, David E / Smiraglia, Dominic / Abrams, Scott I / Pili, Roberto

Clinical cancer research : an official journal of the American Association for Cancer Research

2018 Volume 24, Issue 24, Page(s) 6383–6395

Abstract: ... modifiable through dietary interventions. We tested the hypothesis that dietary protein restriction modifies ... function via a ROS/mTOR-centric cascade.: Conclusions: Dietary protein restriction alters TAM activity ... Purpose: Diet and healthy weight are established means of reducing cancer incidence and mortality ...

Abstract	Purpose: Diet and healthy weight are established means of reducing cancer incidence and mortality. However, the impact of diet modifications on the tumor microenvironment and antitumor immunity is not well defined. Immunosuppressive tumor-associated macrophages (TAMs) are associated with poor clinical outcomes and are potentially modifiable through dietary interventions. We tested the hypothesis that dietary protein restriction modifies macrophage function toward antitumor phenotypes. Experimental design: Macrophage functional status under different tissue culture conditions and Results: Protein or AA-restricted macrophages exhibited enhanced tumoricidal, proinflammatory phenotypes, and in two syngeneic tumor models, protein or AA-restricted diets elicited reduced TAM infiltration, tumor growth, and increased response to immunotherapies. Further, we identified a distinct molecular mechanism by which AA-restriction reprograms macrophage function via a ROS/mTOR-centric cascade. Conclusions: Dietary protein restriction alters TAM activity and enhances the tumoricidal capacity of this critical innate immune cell type, providing the rationale for clinical testing of this supportive tool in patients receiving cancer immunotherapies.
MeSH term(s)	Amino Acids/metabolism ; Animals ; Cell Line, Tumor ; Cytokines/metabolism ; Diet, Protein-Restricted ; Dietary Proteins/metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome ; Humans ; Immunomodulation ; Immunotherapy ; Macrophage Activation/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Transgenic ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Polyamines/metabolism
Chemical Substances	Amino Acids ; Cytokines ; Dietary Proteins ; Polyamines
Language	English
Publishing date	2018-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-18-0980
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Article ; Online: Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks, Oliver D K / Athineos, Dimitris / Cheung, Eric C / Lee, Pearl / Zhang, Tong / van den Broek, Niels J F / Mackay, Gillian M / Labuschagne, Christiaan F / Gay, David / Kruiswijk, Flore / Blagih, Julianna / Vincent, David F / Campbell, Kirsteen J / Ceteci, Fatih / Sansom, Owen J / Blyth, Karen / Vousden, Karen H

Nature

2017 Volume 544, Issue 7650, Page(s) 372–376

Abstract: The non-essential amino acids serine and glycine are used in multiple anabolic processes ... novo serine synthesis, many others rely on exogenous serine for optimal growth. Restriction of dietary ... The increased survival following dietary restriction of serine and glycine in these models was further improved ...

Abstract	The non-essential amino acids serine and glycine are used in multiple anabolic processes that support cancer cell growth and proliferation (reviewed in ref. 1). While some cancer cells upregulate de novo serine synthesis, many others rely on exogenous serine for optimal growth. Restriction of dietary serine and glycine can reduce tumour growth in xenograft and allograft models. Here we show that this observation translates into more clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer (driven by Apc inactivation) or lymphoma (driven by Myc activation). The increased survival following dietary restriction of serine and glycine in these models was further improved by antagonizing the anti-oxidant response. Disruption of mitochondrial oxidative phosphorylation (using biguanides) led to a complex response that could improve or impede the anti-tumour effect of serine and glycine starvation. Notably, Kras-driven mouse models of pancreatic and intestinal cancers were less responsive to depletion of serine and glycine, reflecting an ability of activated Kras to increase the expression of enzymes that are part of the serine synthesis pathway and thus promote de novo serine synthesis.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Biguanides/pharmacology ; Cell Line, Tumor ; Diet ; Disease Models, Animal ; Female ; Food Deprivation ; Glycine/deficiency ; Glycine/metabolism ; Humans ; Intestinal Neoplasms/diet therapy ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Lymphoma/diet therapy ; Lymphoma/metabolism ; Lymphoma/pathology ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Nutritional Status ; Oxidative Phosphorylation/drug effects ; Pancreatic Neoplasms/diet therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Serine/biosynthesis ; Serine/deficiency ; Serine/metabolism ; Serine/pharmacology ; Survival Rate
Chemical Substances	Antioxidants ; Biguanides ; Serine (452VLY9402) ; Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2017-04-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature22056
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Article ; Online: Tolvaptan corrects hyponatremia and relieves the burden of fluid/dietary restriction and hospitalization in hyponatremic patients with terminal lung cancer: a report of two cases.

Kai, Keiko / Tominaga, Naoto / Koitabashi, Kenichiro / Ichikawa, Daisuke / Shibagaki, Yugo

CEN case reports

2019 Volume 8, Issue 2, Page(s) 112–118

Abstract: ... restriction of 500 mL/day, and amino acid supplementation to maintain a urea load of 31 g/day. Due ... by eliminating the need for dietary restriction.Case 2: An 88-year-old man with asymptomatic hyponatremia was ... In addition to chemotherapy, the patient was treated with increased dietary salt intake (15 g/day), fluid ...

Abstract	Case 1: A 45-year-old man, admitted for symptomatic hyponatremia, was diagnosed with advanced small-cell lung cancer and severe hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone. In addition to chemotherapy, the patient was treated with increased dietary salt intake (15 g/day), fluid restriction of 500 mL/day, and amino acid supplementation to maintain a urea load of 31 g/day. Due to the difficulty in changing his habit of drinking 2-3 L/day after discharge, tolvaptan was started. This resulted in correction of hyponatremia, which facilitated earlier discharge and improved his quality of life by eliminating the need for dietary restriction.Case 2: An 88-year-old man with asymptomatic hyponatremia was admitted for assessment of pleural effusion. He was diagnosed with small-cell lung cancer with mild hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone. He was treated with best supportive care and dietary modification (salt intake of 15 g/day and fluid restriction of 400 mL/day). He found it difficult to comply with the dietary changes, and prolonged hospitalization was required for hyponatremia correction. Therefore, tolvaptan was initiated, which corrected his hyponatremia, and the patient was discharged.In summary, tolvaptan results in stable correction of hyponatremia in patients with terminal small-cell lung cancer complicated by the syndrome of inappropriate secretion of antidiuretic hormone. Furthermore, it improves the quality of life of these patients by relieving the burden of strict dietary modifications and prolonged hospitalization.
MeSH term(s)	Aged, 80 and over ; Antidiuretic Hormone Receptor Antagonists/therapeutic use ; Hospitalization ; Humans ; Hyponatremia/drug therapy ; Hyponatremia/etiology ; Inappropriate ADH Syndrome/diagnosis ; Inappropriate ADH Syndrome/diet therapy ; Inappropriate ADH Syndrome/drug therapy ; Inappropriate ADH Syndrome/etiology ; Male ; Middle Aged ; Patient Discharge ; Quality of Life ; Small Cell Lung Carcinoma/complications ; Tolvaptan/therapeutic use ; Treatment Outcome
Chemical Substances	Antidiuretic Hormone Receptor Antagonists ; Tolvaptan (21G72T1950)
Language	English
Publishing date	2019-01-14
Publishing country	Japan
Document type	Case Reports ; Journal Article
ISSN	2192-4449
ISSN (online)	2192-4449
DOI	10.1007/s13730-019-00375-7
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Article ; Online: In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles.

Eitan, Erez / Tosti, Valeria / Suire, Caitlin N / Cava, Edda / Berkowitz, Sean / Bertozzi, Beatrice / Raefsky, Sophia M / Veronese, Nicola / Spangler, Ryan / Spelta, Francesco / Mustapic, Maja / Kapogiannis, Dimitrios / Mattson, Mark P / Fontana, Luigi

Aging cell

2017 Volume 16, Issue 6, Page(s) 1430–1433

Abstract: ... protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases ... diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary ... systemic leptin and insulin signaling and respond to dietary interventions. We studied plasma samples ...

Abstract	Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age-associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions. We studied plasma samples from men with prostate cancer awaiting prostatectomy who participated in a randomized trial of one month of PR or control diet. We found increased levels of leptin receptor in the PR group in total plasma EVs and in a subpopulation of plasma EVs expressing the neuronal marker L1CAM. Protein restriction also shifted the phosphorylation status of the insulin receptor signal transducer protein IRS1 in L1CAM+ EVs in a manner suggestive of improved insulin sensitivity. Dietary PR modifies indicators of leptin and insulin signaling in circulating EVs. These findings are consistent with improved insulin and leptin sensitivity in response to PR and open a new window for following physiologic responses to dietary interventions in humans.
MeSH term(s)	Caloric Restriction ; Diet, Protein-Restricted ; Energy Metabolism ; Extracellular Vesicles/metabolism ; Humans ; Insulin/blood ; Leptin/blood ; Male ; Middle Aged ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diet therapy ; Prostatic Neoplasms/pathology
Chemical Substances	Insulin ; Leptin
Language	English
Publishing date	2017-09-17
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.12657
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Article ; Online: Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model.

Lamming, Dudley W / Cummings, Nicole E / Rastelli, Antonella L / Gao, Feng / Cava, Edda / Bertozzi, Beatrice / Spelta, Francesco / Pili, Roberto / Fontana, Luigi

Oncotarget

2015 Volume 6, Issue 31, Page(s) 31233–31240

Abstract: ... responsive to acute treatment with amino acids in cell culture and in vivo. We found that both PR and ... but not IF, selectively inhibits the activity of the amino acid sensitive mTORC1, while the activity ... Reduced dietary protein intake and intermittent fasting (IF) are both linked to healthy longevity ...

Abstract	Reduced dietary protein intake and intermittent fasting (IF) are both linked to healthy longevity in rodents, and are effective in inhibiting cancer growth. The molecular mechanisms underlying the beneficial effects of chronic protein restriction (PR) and IF are unclear, but may be mediated in part by a down-regulation of the IGF/mTOR pathway. In this study we compared the effects of PR and IF on tumor growth in a xenograft mouse model of breast cancer. We also investigated the effects of PR and IF on the mechanistic Target Of Rapamycin (mTOR) pathway, inhibition of which extends lifespan in model organisms including mice. The mTOR protein kinase is found in two distinct complexes, of which mTOR complex 1 (mTORC1) is responsive to acute treatment with amino acids in cell culture and in vivo. We found that both PR and IF inhibit tumor growth and mTORC1 phosphorylation in tumor xenografts. In somatic tissues, we found that PR, but not IF, selectively inhibits the activity of the amino acid sensitive mTORC1, while the activity of the second mTOR complex, mTORC2, was relatively unaffected by PR. In contrast, IF resulted in increased S6 phosphorylation in multiple metabolic tissues. Our work represents the first finding that PR may reduce mTORC1 activity in tumors and multiple somatic tissues, and suggest that PR may represent a highly translatable option for the treatment not only of cancer, but also other age-related diseases.
MeSH term(s)	Animals ; Blotting, Western ; Breast Neoplasms/diet therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Dietary Proteins/administration & dosage ; Dietary Proteins/pharmacology ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Multiprotein Complexes/antagonists & inhibitors ; Multiprotein Complexes/metabolism ; Phosphorylation ; Signal Transduction ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Chemical Substances	Dietary Proteins ; Multiprotein Complexes ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1)
Language	English
Publishing date	2015-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.5180
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Article: Can dietary methionine restriction increase the effectiveness of chemotherapy in treatment of advanced cancer?

Epner, D E

Journal of the American College of Nutrition

2001 Volume 20, Issue 5 Suppl, Page(s) 443S–449S; discussion 473S–475S

Abstract: ... therefore desperately needed. Dietary restriction of the essential amino acid methionine offers promise ... restriction for adults with advanced cancer. Preliminary findings from this trial indicate that dietary ... animal studies demonstrate the effectiveness of dietary methionine restriction in inhibiting growth and ...

Abstract	Most metastatic tumors, such as those originating in the prostate, lung, and gastrointestinal tract, respond poorly to conventional chemotherapy. Novel treatment strategies for advanced cancer are therefore desperately needed. Dietary restriction of the essential amino acid methionine offers promise as such a strategy, either alone or in combination with chemotherapy or other treatments. Numerous in vitro and animal studies demonstrate the effectiveness of dietary methionine restriction in inhibiting growth and eventually causing death of cancer cells. In contrast, normal host tissues are relatively resistant to methionine restriction. These preclinical observations led to a phase I clinical trial of dietary methionine restriction for adults with advanced cancer. Preliminary findings from this trial indicate that dietary methionine restriction is safe and feasible for the treatment of patients with advanced cancer. In addition, the trial has yielded some preliminary evidence of antitumor activity. One patient with hormone-independent prostate cancer experienced a 25% reduction in serum prostate-specific antigen (PSA) after 12 weeks on the diet, and a second patient with renal cell cancer experienced an objective radiographic response. The possibility that methionine restriction may act synergistically with other cancer treatments such as chemotherapy is being explored. Findings to date support further investigation of dietary methionine restriction as a novel treatment strategy for advanced cancer.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Drug Synergism ; Humans ; Methionine/administration & dosage ; Methionine/pharmacology ; Neoplasm Metastasis ; Neoplasms/pathology ; Neoplasms/therapy ; Prostate-Specific Antigen/blood ; Safety ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Methionine (AE28F7PNPL) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2001-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
DOI	10.1080/07315724.2001.10719183
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Article: Can dietary methionine restriction increase the effectiveness of chemotherapy in treatment of advanced cancer?

Epner, D.E

Journal of the American College of Nutrition. Oct 2001. v. 20 (5S)

2001

Abstract	Most metastatic tumors, such as those originating in the prostate, lung, and gastrointestinal tract, respond poorly to conventional chemotherapy. Novel treatment strategies for advanced cancer are therefore desperately needed. Dietary restriction of the essential amino acid methionine offers promise as such a strategy, either alone or in combination with chemotherapy or other treatments. Numerous in vitro and animal studies demonstrate the effectiveness of dietary methionine restriction in inhibiting growth and eventually causing death of cancer cells. In contrast, normal host tissues are relatively resistant to methionine restriction. These preclinical observations led to a phase I clinical trial of dietary methionine restriction for adults with advanced cancer. Preliminary findings from this trial indicate that dietary methionine restriction is safe and feasible for the treatment of patients with advanced cancer. In addition, the trial has yielded some preliminary evidence of antitumor activity. One patient with hormone-independent prostate cancer experienced a 25% reduction in serum prostate-specific antigen (PSA) after 12 weeks on the diet, and a second patient with renal cell cancer experienced an objective radiographic response. The possibility that methionine restriction may act synergistically with other cancer treatments such as chemotherapy is being explored. Findings to date support further investigation of dietary methionine restriction as a novel treatment strategy for advanced cancer.
Keywords	neoplasms ; drug therapy ; methionine ; diet ; diet therapy ; metastasis ; mortality ; hosts ; clinical trials ; adverse effects ; synergism
Language	English
Dates of publication	2001-10
Size	p. 443S-449S.
Document type	Article
Note	In the supplement: Synergy in medical nutritional therapy / edited by D.M. Klurfeld and A.M. Flammang. Paper presented at a conference held November 6-8, 2000, Key Largo, Florida.
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
Database	NAL-Catalogue (AGRICOLA)

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