Article ; Online: Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19.
2021 Volume 131, Page(s) 105295
Abstract: ... cytokines such as interleukin-6 (IL-6) could underpin these long-term COVID-19 symptoms. This hypothesis is ... The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such as fatigue ... that IL-6 could represent a possible causal driver for these symptoms. Immune activation following COVID ...
| Abstract | The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune cross-talk via inflammatory cytokines such as interleukin-6 (IL-6) could underpin these long-term COVID-19 symptoms. This hypothesis is supported by several lines of research, including population-based cohort and genetic Mendelian Randomisation studies suggesting that inflammation is associated with fatigue and sleeping difficulties, and that IL-6 could represent a possible causal driver for these symptoms. Immune activation following COVID-19 can disrupt T helper 17 (T |
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| MeSH term(s) | Animals ; Anxiety/epidemiology ; Anxiety/etiology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/psychology ; Cohort Studies ; Depression/epidemiology ; Depression/etiology ; Fatigue/epidemiology ; Fatigue/etiology ; Humans ; Interleukin-6/metabolism ; Interleukin-6/pharmacology ; Interleukin-6/physiology ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Neuroimmunomodulation/drug effects ; Neuroimmunomodulation/physiology ; SARS-CoV-2/physiology ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Survivors/statistics & numerical data ; Post-Acute COVID-19 Syndrome | |||||
| Chemical Substances | Interleukin-6 | |||||
| Language | English | |||||
| Publishing date | 2021-06-03 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 197636-9 | |||||
| ISSN | 1873-3360 ; 0306-4530 | |||||
| ISSN (online) | 1873-3360 | |||||
| ISSN | 0306-4530 | |||||
| DOI | 10.1016/j.psyneuen.2021.105295 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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