Article ; Online: Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study.
Annals of clinical microbiology and antimicrobials
2021 Volume 20, Issue 1, Page(s) 51
Abstract: ... from the pre-pandemic and pandemic era.: Methods: Microbiological database records of all the COVID-19 ... patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups ... Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 ...
| Abstract | Purpose: In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era. Methods: Microbiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data. Results: In total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001). Conclusion: Due to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; COVID-19/epidemiology ; COVID-19/microbiology ; COVID-19 Nucleic Acid Testing ; Child ; Child, Preschool ; Coinfection/epidemiology ; Coinfection/microbiology ; Drug Resistance, Bacterial/drug effects ; Female ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Retrospective Studies ; Turkey/epidemiology ; Young Adult |
| Chemical Substances | Anti-Bacterial Agents |
| Language | English |
| Publishing date | 2021-08-05 |
| Publishing country | England |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 2097873-X |
| ISSN | 1476-0711 ; 1476-0711 |
| ISSN (online) | 1476-0711 |
| ISSN | 1476-0711 |
| DOI | 10.1186/s12941-021-00454-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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