Article ; Online: Proteinuria and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Single-Center Study.
Clinical journal of the American Society of Nephrology : CJASN
2021 Volume 16, Issue 4, Page(s) 514–521
Abstract: ... Proteinuria is very frequent among patients admitted for COVID-19 and may precede AKI. Low levels ... among patients with COVID-19 admitted in a tertiary care hospital in France, and to evaluate its association ... Design , setting, participants measurements: We conducted a single-center retrospective study ...
| Abstract | Background and objectives: Kidney involvement is frequent among patients with coronavirus disease 2019 (COVID-19), and occurrence of AKI is associated with higher mortality in this population. The objective of this study was to describe occurrence and significance of proteinuria in this setting. Design , setting, participants measurements: We conducted a single-center retrospective study to describe the characteristic features of proteinuria measured within 48 hours following admission among patients with COVID-19 admitted in a tertiary care hospital in France, and to evaluate its association with initiation of dialysis, intensive care unit admission, and death. Results: Among 200 patients with available data, urine protein-creatinine ratio at admission was ≥1 g/g for 84 (42%), although kidney function was normal in most patients, with a median serum creatinine of 0.94 mg/dl (interquartile range, 0.75-1.21). Median urine albumin-creatinine ratio was 110 mg/g (interquartile range, 50-410), with a urine albumin-protein ratio <50% in 92% of patients. Urine retinol binding protein concentrations, available for 85 patients, were ≥0.03 mg/mmol in 62% of patients. Urine protein-creatinine ratio ≥1 g/g was associated with initiation of dialysis (odds ratio, 4.87; 95% confidence interval, 2.03 to 13.0; P <0.001), admission to the intensive care unit (odds ratio, 3.55; 95% confidence interval, 1.93 to 6.71; P <0.001), and death (odds ratio, 3.56; 95% confidence interval, 1.90 to 6.54; P <0.001). Conclusions: Proteinuria is very frequent among patients admitted for COVID-19 and may precede AKI. Low levels of albuminuria suggest a predominant tubular origin, confirmed by the elevated levels of urine retinol binding protein. Urine protein-creatinine ratio ≥1 g/g at admission is strongly associated with poor kidney and patient outcome. |
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| Language | English | |||||
| Publishing date | 2021-02-23 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2226665-3 | |||||
| ISSN | 1555-905X ; 1555-9041 | |||||
| ISSN (online) | 1555-905X | |||||
| ISSN | 1555-9041 | |||||
| DOI | 10.2215/CJN.09130620 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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