Article ; Online: COVID‑19 and SARS‑CoV‑2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease.
International journal of molecular medicine
2021 Volume 47, Issue 4
Abstract: ... for the ongoing COVID‑19 pandemic, enters its host cells primarily via the binding of the SARS‑CoV‑2 spike (S ... activate the SARS‑CoV‑2 S proteins, and enhance the viral infection of human small intestinal enterocytes ... proteins to the angiotensin‑converting enzyme 2 (ACE2). A number of other cell entry mediators have also ...
| Abstract | Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2), the causative viral agent for the ongoing COVID‑19 pandemic, enters its host cells primarily via the binding of the SARS‑CoV‑2 spike (S) proteins to the angiotensin‑converting enzyme 2 (ACE2). A number of other cell entry mediators have also been identified, including neuropilin‑1 (NRP1) and transmembrane protease serine 2 (TMPRSS2). More recently, it has been demonstrated that transmembrane protease serine 4 (TMPRSS4) along with TMPRSS2 activate the SARS‑CoV‑2 S proteins, and enhance the viral infection of human small intestinal enterocytes. To date, a systematic analysis of TMPRSS4 in health and disease is lacking. In the present study, using |
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| MeSH term(s) | Brain/enzymology ; COVID-19/enzymology ; COVID-19/genetics ; COVID-19/virology ; Central Nervous System/enzymology ; Computer Simulation ; Databases, Genetic ; Female ; Gastrointestinal Tract/enzymology ; Gene Expression Profiling ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; Male ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Neoplasms/enzymology ; Neoplasms/genetics ; Pandemics ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Serine Endopeptidases/genetics ; Serine Endopeptidases/physiology ; Virus Internalization | |||||
| Chemical Substances | Membrane Proteins ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS4 protein, human (EC 3.4.21.-) | |||||
| Language | English | |||||
| Publishing date | 2021-03-02 | |||||
| Publishing country | Greece | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1444428-8 | |||||
| ISSN | 1791-244X ; 1107-3756 | |||||
| ISSN (online) | 1791-244X | |||||
| ISSN | 1107-3756 | |||||
| DOI | 10.3892/ijmm.2021.4897 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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