Article ; Online: False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic: Clinical implications.
2020 Volume 42, Issue 7, Page(s) 1621–1628
Abstract: Background: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT ... unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest ... Conclusions: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat ...
| Abstract | Background: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening. Methods: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated. Results: Forty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97. Conclusions: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful. |
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| MeSH term(s) | Aged, 80 and over ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Emergencies ; False Positive Reactions ; Female ; Florida/epidemiology ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Nasopharynx/virology ; Otorhinolaryngologic Surgical Procedures ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Preoperative Care ; RNA, Viral ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Young Adult |
| Chemical Substances | RNA, Viral |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-12 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 645165-2 |
| ISSN | 1097-0347 ; 0148-6403 ; 1043-3074 |
| ISSN (online) | 1097-0347 |
| ISSN | 0148-6403 ; 1043-3074 |
| DOI | 10.1002/hed.26317 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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