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Article ; Online: Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury.

Loke, Randy Y J / Chin, Cheen Fei / Liang, Gao / Wong, Bernice H / Galam, Dwight L A / Tan, Bryan C / Chua, Geok-Lin / Minegishi, Shintaro / Morisawa, Norihiko / Sidorov, Iulia / Heijs, Bram / Titze, Jens / Wenk, Markus R / Torta, Federico / Silver, David L

Journal of lipid research

2023 Volume 64, Issue 8, Page(s) 100416

Abstract: ... recovery of renal function after acute IRI, with depressed urine osmolality and elevated levels ... Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity ... that Mfsd2a-mediated transport of LPC-DHA is limiting for renal recovery after AKI and suggest that LPC-DHA ...

Abstract	Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic-reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen. How injured tubules reconstitute lost membrane lipids during renal recovery is not known. Here, we identified Mfsd2a, a sodium-dependent lysophosphatidylcholine (LPC) transporter, to be expressed specifically in the basolateral membrane of S3 PT. Using an in vivo activity probe for Mfsd2a, transport activity was found to be specific to the S3 PT. Mice with haploinsufficiency of Mfsd2a exhibited delayed recovery of renal function after acute IRI, with depressed urine osmolality and elevated levels of histological markers of damage, fibrosis, and inflammation, findings corroborated by transcriptomic analysis. Lipidomics revealed a deficiency in docosahexaenoic acid (DHA) containing phospholipids in Mfsd2a haploinsufficiency. Treatment of Mfsd2a haploinsufficient mice with LPC-DHA improved renal function and reduced markers of injury, fibrosis, and inflammation. Additionally, LPC-DHA treatment restored S3 brush border membrane architecture and normalized DHA-containing phospholipid content. These findings indicate that Mfsd2a-mediated transport of LPC-DHA is limiting for renal recovery after AKI and suggest that LPC-DHA could be a promising dietary supplement for improving recovery following AKI.
MeSH term(s)	Mice ; Animals ; Symporters ; Membrane Transport Proteins ; Docosahexaenoic Acids ; Acute Kidney Injury ; Phospholipids ; Kidney/physiology
Chemical Substances	Symporters ; Membrane Transport Proteins ; Docosahexaenoic Acids (25167-62-8) ; Phospholipids ; Mfsd2a protein, mouse
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2023.100416
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Article ; Online: Clinical and Biochemical Profile Associated with Renal Recovery after Acute Kidney Injury in A Mexican Population: Retrospective Cohort Study.

Ruiz-Gallardo, Josué I / Cervantes-Pérez, Enrique / Pérez de Acha-Chávez, Andrea / Cervantes-Cardona, Guillermo A / Ramírez-Ochoa, Sol / Nápoles-Echauri, Adriana / González-Ojeda, Alejandro / Fuentes-Orozco, Clotilde / Hernández-Mora, Francisco Javier / Gómez-Sánchez, Eduardo / Michel-González, Jorge I / González-Valencia, Carlos Miguel / Cervantes-Guevara, Gabino

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Retrospective Studies ; Creatinine ; Procalcitonin ; Renal Insufficiency, Chronic/complications ; Acute Kidney Injury/complications ; Glomerular Filtration Rate
Chemical Substances	Creatinine (AYI8EX34EU) ; Procalcitonin
Language	English
Publishing date	2023-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050889
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Article ; Online: Early renal recovery after acute kidney injury in patients on venoarterial extracorporeal membrane oxygenation: A retrospective study.

Sitbon, Alexandre / Coutrot, Maxime / Montero, Santiago / Chommeloux, Juliette / Lebreton, Guillaume / Huang, Florent / Frapard, Thomas / Assouline, Benjamin / Pineton De Chambrun, Marc / Hekimian, Guillaume / Luyt, Charles Edouard / Combes, Alain / Schmidt, Matthieu

Journal of critical care

2023 Volume 78, Page(s) 154368

Abstract: ... in patients with pre-ECMO acute kidney injury and cardiogenic shock is unknown.: Material and methods ... Purpose: The impact of VA-ECMO on early renal recovery (within 7 days after ECMO onset ... within 7 days after VA-ECMO onset. The median time to early renal recovery was 4 (3,6) days. Nephrotoxic ...

Abstract	Purpose: The impact of VA-ECMO on early renal recovery (within 7 days after ECMO onset) in patients with pre-ECMO acute kidney injury and cardiogenic shock is unknown. Material and methods: This retrospective single-center study included adult patients with cardiogenic shock rescued by VA-ECMO and severe AKI occurring before ECMO implantation (pre-ECMO AKI). Patients with early renal recovery (defined as at least a 50% decrease in peak serum creatinine or weaning from renal replacement therapy) were compared to patients without early renal recovery. Results: During 7 years, 145 patients with severe pre-ECMO AKI were included. Eighty-two patients had no early renal recovery whereas 63 had early renal recovery within 7 days after VA-ECMO onset. The median time to early renal recovery was 4 (3,6) days. Nephrotoxic antibiotics (HR = 0.35 [95% CI, 0.21-0.59], p < 0.001), median fluid balance during the first 7 days of VA-ECMO (HR = 0.77 [95% CI, 0.64-0.93], p = 0.008), pre-ECMO AKI stage 3 (HR = 0.36 [95% CI, 0.20-0.64], p < 0.001) and median vasoactive-inotropic score (HR = 0.99 [95% CI, 0.98,1.00], p = 0.035) were independently associated with no early renal recovery. Conclusions: Only 43% of patients with severe pre-ECMO AKI had early renal recovery after VA-ECMO initiation.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Shock, Cardiogenic/therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Acute Kidney Injury/therapy ; Acute Kidney Injury/etiology ; Renal Replacement Therapy
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2023.154368
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Article ; Online: Biomarkers of persistent renal vulnerability after acute kidney injury recovery.

Fuentes-Calvo, Isabel / Cuesta, Cristina / Sancho-Martínez, Sandra M / Hidalgo-Thomas, Omar A / Paniagua-Sancho, María / López-Hernández, Francisco J / Martínez-Salgado, Carlos

Scientific reports

2021 Volume 11, Issue 1, Page(s) 21183

Abstract: Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney ... two potential diagnostic tools to monitor the sequelae and kidney vulnerability after the apparent ... subclinical sequelae persisting after recovery from cisplatin-induced AKI in rats. Compared to controls, after ...

Abstract	Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney disease, cardiovascular events and death, as renal repair may be deficient and maladaptive, and activate proinflammatory and profibrotic signals. AKI and AKI recovery definitions are based on changes in plasma creatinine, a parameter mostly associated to glomerular filtration, but largely uncoupled from renal tissue damage. The evolution of structural and functional repair has been incompletely described. We thus aimed at identifying subclinical sequelae persisting after recovery from cisplatin-induced AKI in rats. Compared to controls, after plasma creatinine recovery, post-AKI kidneys showed histological alterations and attendant susceptibility to new AKI episodes. Tubular function (assessed by the furosemide stress test, FST) also remained affected. Lingering parenchymal and functional subclinical alterations were paralleled by tapering, but abnormally high levels of urinary albumin, transferrin, insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinases-2 (TIMP-2) and, especially, the [TIMP-2][IGFBP7] product. As subclinical surrogates of incomplete renal recovery, the FST and the urinary [TIMP-2][IGFBP7] product provide two potential diagnostic tools to monitor the sequelae and kidney vulnerability after the apparent recovery from AKI.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/urine ; Animals ; Antineoplastic Agents/toxicity ; Biomarkers/urine ; Cisplatin/toxicity ; Insulin-Like Growth Factor Binding Proteins/urine ; Kidney/drug effects ; Kidney/pathology ; Kidney/physiopathology ; Male ; Rats ; Rats, Wistar ; Tissue Inhibitor of Metalloproteinase-2/urine
Chemical Substances	Antineoplastic Agents ; Biomarkers ; Insulin-Like Growth Factor Binding Proteins ; insulin-like growth factor binding protein-related protein 1 ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-00710-y
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Article ; Online: Renal recovery after acute kidney injury in a minority population of hospitalized COVID-19 patients: A retrospective cohort study.

Sarwal, Amara / Gomez, Edgar / Perez-Gutierrez, Victor / Carlos, Alex / Afzal, Afsheen / Sivakumar, Mangai / Rabah, Sami / Kasubhai, Moiz / Gnanasekaran, Isaiarasi / Menon, Vidya

Medicine

2022 Volume 101, Issue 11

Abstract: ... infection and acute kidney injury (AKI) that recover their renal function or progress to acute ... in the analysis, 71.8% had renal recovery (RR) while 28.2% were discharged with AKD. The AKD subset has higher ... kidney disease (AKD) on discharge; and determine factors associated with progression to AKD during hospital stay ...

Abstract	Abstract: This study aimed to characterize survivors of Coronavirus disease 2019 (COVID-19) infection and acute kidney injury (AKI) that recover their renal function or progress to acute kidney disease (AKD) on discharge; and determine factors associated with progression to AKD during hospital stay.One thousand seventy four patients with COVID-19 infection were followed up until discharge/death. The incidence of AKI was 59.7%. Two hundred and sixty-six patients were discharged alive and included in the analysis, 71.8% had renal recovery (RR) while 28.2% were discharged with AKD. The AKD subset has higher rate of chronic kidney disease (CKD) ≥3 (33.4% vs 14.1%, P = .001), congestive heart failure (18.7% vs 5.8%, P = .001), use of non-invasive mechanical ventilation (10.7% vs 3.7%, P = .026) and vasopressors (25.3% vs 12.0%, P = .007). Of 19 patients in the AKI survivor cohort who received renal replacement therapy, 1 had RR while 18 progressed to AKD on discharge. Predictors to progression to AKD were CKD ≥3 (Odds Ratio [OR]: 3.23, 95% confidence interval [CI] 1.59-6.56, P = .001), congestive heart failure (OR: 4.59, 95% CI 1.76-11.78, P = .002), AKI on admission (OR: 2.71, 95% CI, 1.14-6.46, P = .025), and ongoing diarrhea (OR: 3.19, 95% CI, 1.02-9.96, P = .025).This study demonstrates a higher proportion of RR among survivors of COVID-19 infection in our minority predominant cohort. Early identification and appropriate management of patients at-risk to progress to AKD could improve outcomes, reduce long term sequalae of CKD/end stage renal disease, and have a major impact on health outcome and financial strain on healthcare system.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Cohort Studies ; Humans ; Kidney/physiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028995
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Article ; Online: Tubular Recovery after Acute Kidney Injury.

Fattah, Hadi / Vallon, Volker

Nephron

2018 Volume 140, Issue 2, Page(s) 140–143

Abstract: Background: A significant portion of patients who are affected by acute kidney injury (AKI) do not ... is vital for recovery of kidney function including improvement of GFR, and likely determines ... recovery with consequences for kidney outcome. ...

Abstract	Background: A significant portion of patients who are affected by acute kidney injury (AKI) do not fully recover due to largely unclear reasons. Restoration of tubular function has been proposed to be a prerequisite for glomerular filtration rate (GFR) recovery. Summary: Proximal tubular cells dedifferentiate during the tubular injury phase, which is required for subsequent cell proliferation and replacement of lost epithelial cells. Experimental studies indicate that some cells fail to redifferentiate and continue to produce growth factors (e.g., transforming growth factor β) that can induce fibrosis. Preclinical studies provide first evidence for beneficial effects of inhibiting glucose transport in the proximal tubule in models of ischemia-reperfusion injury. Comparing renal RNA sequencing data with kidney function during recovery from varying levels of AKI may provide new cues with regard to the sequence of events and help identify key determinants of recovery from AKI. Key Messages: Tubular recovery after AKI is vital for recovery of kidney function including improvement of GFR, and likely determines which patients fully recover from AKI or progress to chronic kidney disease. There is a need to better understand the sequence of events and the processes of tubular cell proliferation and repair, including safe strategies to intervene. The temporary inhibition of selected tubular transport processes, possibly in selected nephron regions, may provide an opportunity to improve tubular cell energetics and facilitate tubular cell recovery with consequences for kidney outcome.
MeSH term(s)	Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Glucose/metabolism ; Humans ; Kidney Tubules/pathology ; Recovery of Function
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-05-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	207121-6
ISSN	2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
ISSN (online)	2235-3186 ; 1423-0186
ISSN	1660-8151 ; 0028-2766
DOI	10.1159/000490007
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Article ; Online: Recovery after Acute Kidney Injury.

Kellum, John A / Sileanu, Florentina E / Bihorac, Azra / Hoste, Eric A J / Chawla, Lakhmir S

American journal of respiratory and critical care medicine

2016 Volume 195, Issue 6, Page(s) 784–791

Abstract: Rationale: Little is known about how acute kidney injury (AKI) resolves, and whether patterns ... of reversal of renal dysfunction differ among patients with respect to ultimate recovery.: Objectives ... defined as alive and no longer meeting criteria for even stage 1. Recovery was defined as reversal ...

Abstract	Rationale: Little is known about how acute kidney injury (AKI) resolves, and whether patterns of reversal of renal dysfunction differ among patients with respect to ultimate recovery. Objectives: We sought to examine different patterns for AKI reversal that are found in patients and assess how they relate to postdischarge outcomes. Methods: We studied 16,968 critically ill patients with Kidney Disease Improving Global Outcomes stage 2 or 3 AKI, using an electronic database. Reversal of AKI was defined as alive and no longer meeting criteria for even stage 1. Recovery was defined as reversal at hospital discharge. Measurements and main results: We observed five patterns. The most common (4,508; 26.6%) was early reversal that was sustained through discharge, but almost as many patients (4,496; 26.5%) had no reversal at all. The remaining patients had late reversal after Day 7 (9.7%); early reversal with one or more relapses, but with ultimate recovery (22.5%); and relapsing without recovery (14.7%). Outcomes for patients with these phenotypes were quite different, with age-adjusted 1-year survival varying from more than 90% for early reversal to less than 40% for patients never reversing. Relapses are common (37.3%), especially in the first 72 hours after reversal, and are associated with a fivefold increased risk for death by 1 year compared with early sustained reversal. Conclusions: We have identified five distinct recovery phenotypes on the basis of the clinical course over the first week after AKI manifestation. These phenotypes may identify patients amenable to therapeutic intervention. Long-term outcomes are associated with recovery status at hospital discharge.
MeSH term(s)	Acute Kidney Injury/therapy ; Aged ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Patient Discharge/statistics & numerical data ; Recurrence ; Renal Dialysis ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2016-09-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201604-0799OC
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Article: Recovery after acute kidney injury requiring kidney replacement therapy in patients with left ventricular assist device: A meta-analysis.

Kovvuru, Karthik / Kanduri, Swetha R / Thongprayoon, Charat / Bathini, Tarun / Vallabhajosyula, Saraschandra / Kaewput, Wisit / Mao, Michael A / Cheungpasitporn, Wisit / Kashani, Kianoush B

World journal of critical care medicine

2021 Volume 10, Issue 6, Page(s) 390–400

Abstract: Background: Acute kidney injury (AKI) is a common and severe complication after left ventricular ... evaluating the recovery rates from severe AKI-KRT after LVAD placement, which is defined by regained kidney ... Follow-up time ranged anywhere from two weeks of LVAD implantation to 12 mo. Kidney recovery occurred ...

Abstract	Background: Acute kidney injury (AKI) is a common and severe complication after left ventricular assist device (LVAD) implantation with an incidence of 37%; 13% of which require kidney replacement therapy (KRT). Severe AKI requiring KRT (AKI-KRT) in LVAD patients is associated with high short and long-term mortality compared with AKI without KRT. While kidney function recovery is associated with better outcomes, its incidence is unclear among LVAD patients with severe AKI requiring KRT. Aim: To identify studies evaluating the recovery rates from severe AKI-KRT after LVAD placement, which is defined by regained kidney function resulting in the discontinuation of KRT. Random-effects and generic inverse variance method of DerSimonian-Laird were used to combine the effect estimates obtained from individual studies. Methods: A total of 268 patients from 14 cohort studies that reported severe AKI-KRT after LVAD were included. Follow-up time ranged anywhere from two weeks of LVAD implantation to 12 mo. Kidney recovery occurred in 78% of enrollees at the time of hospital discharge or within 30 d. Overall, the pooled estimated AKI recovery rate among patients with severe AKI-KRT was 50.5% (95%CI: 34.0%-67.0%) at 12 mo follow up. Majority (85%) of patients used continuous-flow LVAD. While the data on pulsatile-flow LVAD was limited, subgroup analysis of continuous-flow LVAD demonstrated that pooled estimated AKI recovery rate among patients with severe AKI-KRT was 52.1% (95%CI: 36.8%-67.0%). Meta-regression analysis did not show a significant association between study year and AKI recovery rate ( Results: A total of 268 patients from 14 cohort studies that reported severe AKI-KRT after LVAD were included. Follow-up time ranged anywhere from two weeks of LVAD implantation to 12 mo. Kidney recovery occurred in 78% of enrollees at the time of hospital discharge or within 30 d. Overall, the pooled estimated AKI recovery rate among patients with severe AKI-KRT was 50.5% (95%CI: 34.0%-67.0%) at 12 mo follow up. Majority (85%) of patients used continuous-flow LVAD. While the data on pulsatile-flow LVAD was limited, subgroup analysis of continuous-flow LVAD demonstrated that pooled estimated AKI recovery rate among patients with severe AKI-KRT was 52.1% (95%CI: 36.8%-67.0%). Meta-regression analysis did not show a significant association between study year and AKI recovery rate ( Conclusion: Recovery from severe AKI-KRT after LVAD occurs approximately 50.5%, and it has not significantly changed over the years despite advances in medicine.
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Journal Article
ISSN	2220-3141
ISSN	2220-3141
DOI	10.5492/wjccm.v10.i6.390
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Article ; Online: Biomarkers of persistent renal vulnerability after acute kidney injury recovery

Isabel Fuentes-Calvo / Cristina Cuesta / Sandra M. Sancho-Martínez / Omar A. Hidalgo-Thomas / María Paniagua-Sancho / Francisco J. López-Hernández / Carlos Martínez-Salgado

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 12

Abstract: Abstract Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney ... two potential diagnostic tools to monitor the sequelae and kidney vulnerability after the apparent ... subclinical sequelae persisting after recovery from cisplatin-induced AKI in rats. Compared to controls, after ...

Abstract	Abstract Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney disease, cardiovascular events and death, as renal repair may be deficient and maladaptive, and activate proinflammatory and profibrotic signals. AKI and AKI recovery definitions are based on changes in plasma creatinine, a parameter mostly associated to glomerular filtration, but largely uncoupled from renal tissue damage. The evolution of structural and functional repair has been incompletely described. We thus aimed at identifying subclinical sequelae persisting after recovery from cisplatin-induced AKI in rats. Compared to controls, after plasma creatinine recovery, post-AKI kidneys showed histological alterations and attendant susceptibility to new AKI episodes. Tubular function (assessed by the furosemide stress test, FST) also remained affected. Lingering parenchymal and functional subclinical alterations were paralleled by tapering, but abnormally high levels of urinary albumin, transferrin, insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinases-2 (TIMP-2) and, especially, the [TIMP-2][IGFBP7] product. As subclinical surrogates of incomplete renal recovery, the FST and the urinary [TIMP-2][IGFBP7] product provide two potential diagnostic tools to monitor the sequelae and kidney vulnerability after the apparent recovery from AKI.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: In vivo evidence for therapeutic applications of beclin 1 to promote recovery and inhibit fibrosis after acute kidney injury.

Shi, Mingjun / Maique, Jenny / Shepard, Sierra / Li, Peng / Seli, Olivia / Moe, Orson W / Hu, Ming Chang

Kidney international

2021 Volume 101, Issue 1, Page(s) 63–78

Abstract: ... by ischemia reperfusion injury, but its role in kidney recovery and fibrosis are unknown and its therapeutic potentials have not ... of acute kidney injury (AKI)-ischemia reperfusion injury, cisplatin kidney toxicity, and unilateral ureteric obstruction ... Autophagy regulator beclin 1 activity determines the severity of kidney damage induced ...

Abstract	Autophagy regulator beclin 1 activity determines the severity of kidney damage induced by ischemia reperfusion injury, but its role in kidney recovery and fibrosis are unknown and its therapeutic potentials have not been tested. Here, we explored beclin 1 effects on kidney fibrosis in three models of acute kidney injury (AKI)-ischemia reperfusion injury, cisplatin kidney toxicity, and unilateral ureteric obstruction in mouse strains with three levels of beclin 1 function: normal (wild type), low (heterozygous global deletion of beclin 1, Becn1
MeSH term(s)	Acute Kidney Injury/chemically induced ; Animals ; Beclin-1/genetics ; Beclin-1/metabolism ; Fibrosis ; Kidney/pathology ; Mice ; Mice, Inbred C57BL ; Reperfusion Injury/pathology
Chemical Substances	Beclin-1 ; Becn1 protein, mouse
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.09.030
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