Article ; Online: Clinical and laboratory characteristics of SARS-CoV2-infected paediatric patients in Jordan: serial RT-PCR testing until discharge.
Paediatrics and international child health
2020 Volume 41, Issue 1, Page(s) 83–92
Abstract: ... characteristics, laboratory results and longitudinal RT-PCR- testing pattern in children infected with theSARS ... of patients admitted between 16 March and 23 April 2020. All infected children in Jordan were hospitalised ... Serial RT-PCR testing was undertaken 7 days after the first test and then on alternate days ...
| Abstract | Background: Data on COVID-19 in children are limited. This study aimed to identify the clinical characteristics, laboratory results and longitudinal RT-PCR- testing pattern in children infected with theSARS-CoV2 virus and admitted to a hospital in Jordan. Methods: The study is a retrospective chart review of patients admitted between 16 March and 23 April 2020. All infected children in Jordan were hospitalised. Serial RT-PCR testing was undertaken 7 days after the first test and then on alternate days until discharge. The association between patient symptoms and laboratory results and whether there was a statistically significant median difference in the number of days until negative RT-PCR results between patients was studied. Results: Sixty-one patients with positive SARS-CoV2 swabs were admitted, 34 (55.7%) of whom were symptomatic. The most common symptom was nasal congestion (21/61, 34.3%), followed by generalised malaise and headache (12/6, 19.7%). A rash was detected in 5/61 (8.2%) of them. Fifty-five patients (90.1%) underwent investigations: 4 (7.4%) of them had lymphopenia, 4 (7.4%) had eosinopenia, 8 (14.5%) had eosinophilia, and platelets were elevated in 5 (9.1%) children. CRP was measured in 33/61 (54.1%) patients and all were normal. ESR levels were available for 11/61 (18%) patients and were elevated in 5 (45.5%). There was a statistically significant association between laboratory results and symptom expression ( Conclusion: All children admitted who tested positive for SARS-CoV2 had mild symptoms and five had cutaneous manifestations. RT-PCR may remain positive for over one month. |
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| MeSH term(s) | Adolescent ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/virology ; Child ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Jordan/epidemiology ; Male ; Patient Discharge ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-09-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2649065-1 |
| ISSN | 2046-9055 ; 2046-9047 |
| ISSN (online) | 2046-9055 |
| ISSN | 2046-9047 |
| DOI | 10.1080/20469047.2020.1804733 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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