LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Borna disease virus and deficit schizophrenia.

    Kim, Yong-Ku / Kim, Sang-Hyun / Han, Chang-Su / Lee, Heon-Jeong / Kim, Hyung-Seob / Yoon, Sung-Chul / Kim, Dai-Jin / Song, Ki-Joon / Maes, Michael / Song, Jin-Won

    Acta neuropsychiatrica

    2003  Volume 15, Issue 5, Page(s) 262–265

    Abstract: Background: It is controversial whether Borna disease virus (BDV) infects humans and causes ... psychiatric disorders.: Objectives: The relationship between BDV infection and schizophrenia with deficit ... and the deficit form of schizophrenia. ...

    Abstract Background: It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders.
    Objectives: The relationship between BDV infection and schizophrenia with deficit syndrome was investigated.
    Study design: Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40.
    Results and conclusions: BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.
    Language English
    Publishing date 2003-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1034/j.1601-5215.2003.00043.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Borna disease virus antibodies and the deficit syndrome of schizophrenia.

    Waltrip, R W / Buchanan, R W / Carpenter, W T / Kirkpatrick, B / Summerfelt, A / Breier, A / Rubin, S A / Carbone, K M

    Schizophrenia research

    1997  Volume 23, Issue 3, Page(s) 253–257

    Abstract: ... possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia. ... We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients ... with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out ...

    Abstract We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out in a subset of 64 patients categorized according to the Schedule for the Deficit Syndrome with 5/15 seropositive deficit and 4/49 seropositive nondeficit (p < 0.05). This suggests that the antibodies and possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia.
    MeSH term(s) Adult ; Affective Symptoms/virology ; Borna disease virus/immunology ; Case-Control Studies ; Chi-Square Distribution ; Cognition Disorders/virology ; Cohort Studies ; Female ; Humans ; Male ; Schizophrenia/classification ; Schizophrenia/virology ; Syndrome
    Language English
    Publishing date 1997-02-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/s0920-9964(96)00114-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 543: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Investigations of cerebrospinal fluid in Borna disease virus seropositive psychiatric patients.

    Bechter, K / Herzog, S / Behr, W / Schüttler, R

    European psychiatry : the journal of the Association of European Psychiatrists

    2009  Volume 10, Issue 5, Page(s) 250–258

    Abstract: Borna disease virus (BDV) appears to cause meningoencephalitis and schizophreniform psychosis ... could play a more prominent role in a form of "symptomatic" cyclothymia and "symptomatic" schizophrenia ... in experimental Borna disease (BD) in animals, when a majority of the animals showed rather unspecific ...

    Abstract Borna disease virus (BDV) appears to cause meningoencephalitis and schizophreniform psychosis in sporadic cases according to earlier cerebrospinal fluid (CSF) inoculation experiments (Rott et al, 1991). However, CSF parameters in BDV seropositive psychiatric patients proved nearly all normal; only the most sensitive CSF/serum index I-BDV for intrathecally produced BDV specific IgG was pathologic in 10.5-29.0% (according to different methodological limits) of patients. An increase in sensitivity was attempted to detect specific IgG in CSF in a part of the cases by concentration. Concentration procedure does not significantly increase methodological bias according to a statistical analysis of the results. Our findings support the hypothesis that BDV may cause or contribute to the pathogenesis of a diagnostically broad pattern of psychiatric syndromes. The occurence of a spectrum of diagnoses is expected from non-specificity of psychiatric symptoms in other infectious diseases of the brain as well as from results in experimental Borna disease (BD) in animals, when a majority of the animals showed rather unspecific symptomatology due to slight, preferentially limbic encephalitis. Slight deficiencies from an earlier BDV infection could explain continuing symptoms in a part of the cases. Recurrences years after infection are well known in experimental and natural BD in animals. It remains open, whether this mechanism could play a more prominent role in a form of "symptomatic" cyclothymia and "symptomatic" schizophrenia, although the results of CSF investigations are more clear in BDV seropositive patients with major psychoses.
    Language English
    Publishing date 2009-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1074337-6
    ISSN 1778-3585 ; 0924-9338 ; 0767-399X
    ISSN (online) 1778-3585
    ISSN 0924-9338 ; 0767-399X
    DOI 10.1016/0924-9338(96)80302-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 558: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection.

    Dietz, David M / Pletnikov, Mikhail V

    Physiology & behavior

    2003  Volume 80, Issue 2-3, Page(s) 359–366

    Abstract: Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage ... in virus-infected and malnourished rats. The observed dissimilar neuroanatomical and neurochemical ... schizophrenia. Since BDV-infected rats exhibited an inhibition of postnatal weight gain, the present study ...

    Abstract Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage similar to some pathological and clinical features of human developmental disorders, e.g., autism and schizophrenia. Since BDV-infected rats exhibited an inhibition of postnatal weight gain, the present study sought to evaluate a contribution of nutritional status to virus-induced neurodevelopmental injury. We compared neuroanatomical, neurochemical, and behavioral alterations following neonatal BDV infection and rearing in the oversized litters in Fischer344 rats on postnatal day (PND) 26. Despite a comparable weight gain inhibition, different patterns of brain pathology, alterations in brain monoamine systems, and behavioral deficits were observed in the BDV-infected rats compared to the malnourished rats. While no appreciable cell injury was noted in the brains of the malnourished rats, a significant loss of Purkinje cells (PC) and early signs of degeneration of the hippocampal dentate gyrus were found in the BDV-infected rats. Both neonatal BDV infection and postnatal malnourishment increased tissue concentrations of serotonin [5-hydroxytryptamine (5-HT)] in the hippocampus. In contrast, increased turnover of 5-HT in the cortex and hippocampus and elevated turnover of dopamine (DA) in the striatum were found in the malnourished rats only, suggesting that different pathogenic mechanisms might underlie monoamine disturbances in virus-infected and malnourished rats. The observed dissimilar neuroanatomical and neurochemical abnormalities might explain the different responses to novelty in the BDV-infected and malnourished rats. Compared to the control rats, the BDV-infected rats exhibited novelty-induced hyperactivity, while no differences in locomotion were noted between the control and malnourished rats. Taken together, the present data indicate that virus-associated inhibition of postnatal weight gain is unlikely to account for the major BDV-associated neurodevelopmental alterations that seem to be due to specific effects of neonatal BDV infection.
    MeSH term(s) 3,4-Dihydroxyphenylacetic Acid/metabolism ; Aging ; Analysis of Variance ; Animals ; Animals, Newborn ; Behavior, Animal ; Body Weight ; Borna Disease/metabolism ; Borna Disease/physiopathology ; Borna Disease/virology ; Borna disease virus/immunology ; Borna disease virus/pathogenicity ; Brain Chemistry ; Chromatography, High Pressure Liquid ; Dopamine/metabolism ; Electrochemistry ; Female ; Immunohistochemistry ; Male ; Malnutrition/metabolism ; Motor Activity ; Nordefrin/metabolism ; Pregnancy ; Rats ; Rats, Inbred F344 ; Serotonin/metabolism ; Sex Factors ; Weight Gain/physiology
    Chemical Substances 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Serotonin (333DO1RDJY) ; Nordefrin (R81X549E70) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2003-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2003.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 747: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top