Article ; Online: Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation.
2021 Volume 42, Issue 4, Page(s) 312–322
Abstract: ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I interferons (IFN-Is) is ... for efficacy and safety. Here, we discuss how limits placed on IFN-I by SARS-CoV-2 shape the immune response ... CoV-2 infection, which can impair the adaptive immune response and exacerbate inflammatory disease ...
| Abstract | Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I interferons (IFN-Is) is essential for the control of virus replication and for effective antiviral immune responses; for this reason, viruses have evolved the means to antagonize IFN-I. Inhibition of IFN-I production is pronounced in SARS-CoV-2 infection, which can impair the adaptive immune response and exacerbate inflammatory disease at late stages of infection. However, therapeutic boosting of IFN-I offers a narrow time window for efficacy and safety. Here, we discuss how limits placed on IFN-I by SARS-CoV-2 shape the immune response and whether this might be countered with therapeutic approaches and vaccine design. |
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| MeSH term(s) | COVID-19/complications ; COVID-19/immunology ; Humans ; Inflammation/immunology ; Inflammation/virology ; Interferon Type I/immunology ; Virus Replication | ||||||||||
| Chemical Substances | Interferon Type I | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-02-12 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | ||||||||||
| ZDB-ID | 2036831-8 | ||||||||||
| ISSN | 1471-4981 ; 1471-4906 | ||||||||||
| ISSN (online) | 1471-4981 | ||||||||||
| ISSN | 1471-4906 | ||||||||||
| DOI | 10.1016/j.it.2021.02.003 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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