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Article ; Online: Case Report: Ischemic Enterocolitis Associated with Coronavirus Disease 2019: Two Case Reports and a Review of the Literature.

Kinjo, Takeshi / Hokama, Akira / Nakamura, Hideta / Miyagi, Kazuya / Higure, Yuri / Otsuki, Mariko / Nishiyama, Naoya / Nakamatsu, Masashi / Kinjo, Tetsu / Tateyama, Masao / Fujita, Jiro

The American journal of tropical medicine and hygiene

2021  Volume 104, Issue 5, Page(s) 1655–1658

Abstract: ... of ischemic enterocolitis in COVID-19 patients and review past case reports. Our literature review has shown ... its clinical manifestations and pathophysiology is limited. In this case report, we present two cases ... of the vessels and thrombosis; therefore, both patterns of ischemic colitis, occlusive and nonocclusive, may be ...

Abstract The COVID-19 pandemic has caused serious health and social concerns worldwide. Although the primary target of SARS-CoV-2 is the respiratory tract, SARS-CoV-2 infection also causes extrapulmonary symptoms. Previous articles have reported ischemic colitis in COVID-19 patients; however, information regarding its clinical manifestations and pathophysiology is limited. In this case report, we present two cases of ischemic enterocolitis in COVID-19 patients and review past case reports. Our literature review has shown that computed tomography rather than endoscopy was used for the diagnosis, and any region of the intestine was affected. Because the elevation of the D-dimer, which suggested a hypercoagulable state, was reported in most cases, we assumed that thrombosis at any level in the artery and vein was involved in the pathophysiology of COVID-19-associated enterocolitis. SARS-CoV-2-induced endotheliitis can cause both coarctation of the vessels and thrombosis; therefore, both patterns of ischemic colitis, occlusive and nonocclusive, may be involved in COVID-19-associated enterocolitis.
MeSH term(s) Aged ; COVID-19/complications ; Colitis, Ischemic/etiology ; Enterocolitis/etiology ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2
Language English
Publishing date 2021-03-18
Publishing country United States
Document type Case Reports ; Journal Article ; Review
ZDB-ID 2942-7
ISSN 1476-1645 ; 0002-9637
ISSN (online) 1476-1645
ISSN 0002-9637
DOI 10.4269/ajtmh.20-1084
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