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Schlagwörter	Cardiology and Cardiovascular Medicine ; covid19
Sprache	Englisch
Verlag	Elsevier BV
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.09.233
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Artikel: TCT CONNECT-218 Transcatheter Therapies For COVID-19

Kipshidze, N. / White, C. / Reddy, V. / Dangas, G.

Journal of the American College of Cardiology

Abstract: ... Conclusion: Several catheter-based therapies for COVID-19 were discussed It should be noted ... several transcatheter-based approaches for the treatment of COVID-19 Methods: Four transcatheter-based solutions were ... Background: Current strategies for COVID-19 therapy involve the systemic administration of drugs ...

Abstract	Background: Current strategies for COVID-19 therapy involve the systemic administration of drugs While pharmaceutical treatments continue to be evaluated, device-based therapies have yet to be explored We propose several transcatheter-based approaches for the treatment of COVID-19 Methods: Four transcatheter-based solutions were explored in their potential uses for COVID-19 therapy: local drug delivery, energy-based and photodynamic therapy, and neuromodulation Results: First is local, catheter-directed delivery of therapeutics directly to the lungs A localized delivery of therapeutics could increase the bioavailability of drug(s) at the site of action, in comparison to systemic delivery alone A second approach is light-based therapy Considering the antiviral, anti-inflammatory, antimicrobial, and vasculoprotective characteristics of visible light energy (380 to 750 nm), a localized, light-based catheter therapeutic approach could prove to be effective Given the distinct features of COVID-19 disease progression and its attack on hemoglobin and porphyrins, we suggest the infusion of porphyrin-based photosensitizers (PS) COVID-19 has an affinity for PS and would attach to these molecules, which would reduce hypoxic symptoms and allow for their deactivation through the photoactivation or sonoactivation of PS molecules A third approach considers that several studies have demonstrated that viruses hold electrical charges Neutralizing the charge of the virus within an electrical field is feasible to reduce the viral load using pacing wires and catheters placed near lungs A final approach is the neuromodulation of the host inflammatory response In a small preclinical study, the release of proinflammatory cytokines was reduced following transcutaneous low intensity focused ultrasound treatment of the spleen Conclusion: Several catheter-based therapies for COVID-19 were discussed It should be noted that in all approaches, the combination of a catheter-based therapy with systemic pharmaceutical therapy is recommended Robust clinical trials with clinically meaningful and relevant endpoints will be needed to assess the feasibility and safety of these approaches Categories Other: COVID-19
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #887088
Datenquelle	COVID19

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