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  1. Article ; Online: Halting coronavirus polymerase.

    Kirchdoerfer, Robert N

    The Journal of biological chemistry

    2020  Volume 295, Issue 15, Page(s) 4780–4781

    Abstract: ... coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA ... polymerases. In this issue, Gordon ...

    Abstract The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Animals ; Antiviral Agents/pharmacology ; Coronavirus/drug effects ; Coronavirus/enzymology ; Coronavirus/physiology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Exonucleases ; Humans ; Pandemics ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Exonucleases (EC 3.1.-) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.H120.013397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Halting coronavirus polymerase

    Kirchdoerfer, Robert N

    J Biol Chem

    Abstract: ... coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA ... for MERS-CoV polymerase complexes. ... polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator ...

    Abstract The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #686585
    Database COVID19

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  3. Article ; Online: Major royal jelly proteins elicited suppression of SARS-CoV-2 entry and replication with halting lung injury

    Abu-Serie, Marwa M. / Habashy, Noha H.

    International Journal of Biological Macromolecules. 2023 Feb., v. 228 p.715-731

    2023  

    Abstract: ... of PF₅₀ on SARS-CoV-2 replication (RNA-dependent RNA polymerase “RdRp” activity), as well as its impact ...

    Abstract For reasons of high transmissibility and virulence, Alpha (UK, B.1.1.7) and Beta (South African, B.1.351) SARS-CoV-2 variants are classified with other types as variants of concern. Here we report on the influence of royal jelly (RJ) protein fraction (PF)₅₀ (major RJ protein 2 and its isoform X1) on the entry of these variants into the ACE2-human embryonic kidney (HEK) 293 cells using the lentiviral system. The efficiency of PF₅₀ on SARS-CoV-2 replication (RNA-dependent RNA polymerase “RdRp” activity), as well as its impact on bleomycin-induced lung injury in vitro, were also assessed. The PF₅₀ efficiently inhibited infection of kidney cells with the UK and S. African variant spikes of pseudotyped lentivirus particles (IC₅₀ = 7.25 μM and 16.92 μM, respectively) and suppressed the RdRp activity (IC₅₀ = 29.93 μM). Moreover, PF₅₀ displayed protective and therapeutic efficacy against lung injury due to its antioxidant, anti-inflammatory, and angiotensin II blocking activities. The current findings, taken together, offer a novel perspective on PF₅₀ as a promising agent against COVID-19.
    Keywords COVID-19 infection ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; antioxidants ; kidneys ; lungs ; royal jelly ; therapeutics ; virulence ; SARS-CoV-2 ; Lung injury ; Royal jelly proteins
    Language English
    Dates of publication 2023-02
    Size p. 715-731.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.12.251
    Database NAL-Catalogue (AGRICOLA)

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