LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Environmental endocrine disruption of energy metabolism and cardiovascular risk.

    Kirkley, Andrew G / Sargis, Robert M

    Current diabetes reports

    2014  Volume 14, Issue 6, Page(s) 494

    Abstract: ... risk factors, including the contribution of environmental endocrine disrupting chemicals. Epidemiologic and ... Identifying chemicals associated with metabolic and cardiovascular disease as well as their mechanisms ... endocrine disruptors to these key diseases that drive significant individual and societal morbidity and mortality ...

    Abstract Rates of metabolic diseases have increased at an astounding rate in recent decades. Even though poor diet and physical inactivity are central drivers, these lifestyle changes alone fail to fully account for the magnitude and rapidity of the epidemic. Thus, attention has turned to identifying novel risk factors, including the contribution of environmental endocrine disrupting chemicals. Epidemiologic and preclinical data support a role for various contaminants in the pathogenesis of diabetes. In addition to the vascular risk associated with dysglycemia, emerging evidence implicates multiple pollutants in the pathogenesis of atherosclerosis and cardiovascular disease. Reviewed herein are studies linking endocrine disruptors to these key diseases that drive significant individual and societal morbidity and mortality. Identifying chemicals associated with metabolic and cardiovascular disease as well as their mechanisms of action is critical for developing novel treatment strategies and public policy to mitigate the impact of these diseases on human health.
    MeSH term(s) Animals ; Atherosclerosis/chemically induced ; Atherosclerosis/epidemiology ; Atherosclerosis/etiology ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/toxicity ; Energy Metabolism ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Female ; Humans ; Male ; Models, Animal ; Obesity/chemically induced ; Obesity/epidemiology ; Obesity/etiology ; Phenols/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prevalence ; Public Health ; Risk Factors ; Signal Transduction
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Environmental Pollutants ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2014-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-014-0494-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5628: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Environmental impact of endocrine-disrupting chemicals and heavy metals in biological samples of petrochemical industry workers with perspective management.

    Li, Yuanji / Reivan Ortiz, Geovanny Genaro / Uyen, Pham Thi Minh / Cong, Phan The / Othman, Sarah I / Allam, Ahmed A / Unar, Ahsanullah / Afridi, Hassan Imran

    Environmental research

    2023  Volume 231, Issue Pt 2, Page(s) 115913

    Abstract: ... that can lead to negative effect on health, including immune and endocrine system disruption, respiratory ... problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth impairment, neurological and ... of EDCs, are known to pose a significant risk to human health. This study aimed to investigate the levels ...

    Abstract Exposure to endocrine disrupting chemicals (EDCs) or heavy metals are synthetic compounds that can lead to negative effect on health, including immune and endocrine system disruption, respiratory problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth impairment, neurological and learning disabilities, and cancer. Petrochemical industry drilling wastes, which contain varying levels of EDCs, are known to pose a significant risk to human health. This study aimed to investigate the levels of toxic elements in biological samples of individuals working in the petrochemical drilling sites. Biological samples, including scalp hair and whole blood, were collected from petrochemical drilling workers, individuals residing in the same residential area, and control age-matched persons from nonindustrial areas. The samples were oxidized by an acid mixture before analysis using atomic absorption spectrophotometry. The accuracy and validity of the methodology were verified through certified reference materials from scalp hair and whole blood. The results showed that the concentrations of toxic elements, such as cadmium and lead, were higher in biological samples of petrochemical drilling employees, while lower essential element levels (iron and zinc) were detected in their samples. This study highlights the significance of adopting better practices to reduce exposure to harmful substances and protect the health of petrochemical drilling workers and the environment. It also suggests that perspective management including policymakers and industry leaders should take measures to minimize exposure to EDCs and heavy metals to promote worker safety and public health. These measures could include the implementation of strict regulations and better occupational health practices to reduce toxic exposure and promote a safer work environment.
    MeSH term(s) Humans ; Cadmium/analysis ; Endocrine Disruptors/analysis ; Environment ; Hair/chemistry ; Metals, Heavy/analysis ; Occupational Exposure/standards ; Environmental Pollutants/analysis
    Chemical Substances Cadmium (00BH33GNGH) ; Endocrine Disruptors ; Metals, Heavy ; Environmental Pollutants
    Language English
    Publishing date 2023-05-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115913
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Environmental impact of endocrine-disrupting chemicals and heavy metals in biological samples of petrochemical industry workers with perspective management

    Li, Yuanji / Reivan Ortiz, Geovanny Genaro / Uyen, Pham Thi Minh / Cong, Phan The / Othman, Sarah I. / Allam, Ahmed A / Unar, Ahsanullah / Afridi, Hassan Imran

    Environmental Research. 2023 Aug., v. 231 p.115913-

    2023  

    Abstract: ... that can lead to negative effect on health, including immune and endocrine system disruption, respiratory ... problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth impairment, neurological and ... of EDCs, are known to pose a significant risk to human health. This study aimed to investigate the levels ...

    Abstract Exposure to endocrine disrupting chemicals (EDCs) or heavy metals are synthetic compounds that can lead to negative effect on health, including immune and endocrine system disruption, respiratory problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth impairment, neurological and learning disabilities, and cancer. Petrochemical industry drilling wastes, which contain varying levels of EDCs, are known to pose a significant risk to human health. This study aimed to investigate the levels of toxic elements in biological samples of individuals working in the petrochemical drilling sites. Biological samples, including scalp hair and whole blood, were collected from petrochemical drilling workers, individuals residing in the same residential area, and control age-matched persons from nonindustrial areas. The samples were oxidized by an acid mixture before analysis using atomic absorption spectrophotometry. The accuracy and validity of the methodology were verified through certified reference materials from scalp hair and whole blood. The results showed that the concentrations of toxic elements, such as cadmium and lead, were higher in biological samples of petrochemical drilling employees, while lower essential element levels (iron and zinc) were detected in their samples. This study highlights the significance of adopting better practices to reduce exposure to harmful substances and protect the health of petrochemical drilling workers and the environment. It also suggests that perspective management including policymakers and industry leaders should take measures to minimize exposure to EDCs and heavy metals to promote worker safety and public health. These measures could include the implementation of strict regulations and better occupational health practices to reduce toxic exposure and promote a safer work environment.
    Keywords atomic absorption spectrometry ; blood ; cadmium ; diabetes ; endocrine system ; environmental impact ; hairs ; human health ; iron ; lead ; obesity ; occupational health and safety ; oil and gas industry ; public health ; research ; residential areas ; risk ; toxicity ; working conditions ; zinc ; Endocrine-disrupting chemicals ; Petrochemical drilling workers ; Environmental threat ; Atomic absorption spectrophotometer ; Heavy metals ; Perspective management
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115913
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Polycystic ovary syndrome and environmental toxins.

    Rutkowska, Aleksandra Zofia / Diamanti-Kandarakis, Evanthia

    Fertility and sterility

    2016  Volume 106, Issue 4, Page(s) 948–958

    Abstract: ... and cardiovascular disease. Since wide exposure to environmental toxins and their role ... such as bisphenol A (BPA) or phthalates, which belong to the categories of endocrine disrupting chemicals (EDCs) and ... Polycystic ovary syndrome (PCOS) is the most common, heterogeneous, and multifactorial endocrine ...

    Abstract Polycystic ovary syndrome (PCOS) is the most common, heterogeneous, and multifactorial endocrine disorder in premenopausal women. The pathophysiology of this endocrinopathy is still unclear; however, the heterogeneity of its features within ethnic races, geographic location, and families suggests that environment and lifestyle are of prime importance. This work is mainly focused on the possible role of the most common and studied environmental toxins for this syndrome in the pathogenesis of PCOS. Plasticizers, such as bisphenol A (BPA) or phthalates, which belong to the categories of endocrine disrupting chemicals (EDCs) and advanced glycation end products (AGEs), affect humans' health in everyday, industrialized life; therefore special attention should be paid to such exposure. Timing of exposure to EDCs is crucial for the intensity of adverse health effects. It is now evident that fetuses, infants, and/or young children are the most susceptible groups, especially in the early development periods. Prenatal exposure to EDCs that mimic endogenous hormones may contribute to the altered fetal programming and in consequence lead to PCOS and other adverse health effects, potentially transgenerationally. Acute or prolonged exposure to EDCs and AGEs through different life cycle stages may result in destabilization of the hormonal homeostasis and lead to disruption of reproductive functions. They may also interfere with metabolic alterations such as obesity, insulin resistance, and compensatory hyperinsulinemia that can exacerbate the PCOS phenotype and contribute to PCOS consequences such as type 2 diabetes and cardiovascular disease. Since wide exposure to environmental toxins and their role in the pathophysiology of PCOS are supported by extensive data derived from diverse scientific models, protective strategies and strong recommendations should be considered to reduce human exposure to protect present and future generations from their adverse health effects.
    MeSH term(s) Animals ; Endocrine Disruptors/adverse effects ; Environmental Exposure/adverse effects ; Environmental Pollutants/adverse effects ; Female ; Glycation End Products, Advanced/metabolism ; Gonadal Steroid Hormones/biosynthesis ; Humans ; Insulin Resistance ; Obesity/complications ; Ovary/drug effects ; Ovary/metabolism ; Ovary/pathology ; Ovary/physiopathology ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/metabolism ; Polycystic Ovary Syndrome/pathology ; Polycystic Ovary Syndrome/physiopathology ; Risk Assessment ; Risk Factors
    Chemical Substances Endocrine Disruptors ; Environmental Pollutants ; Glycation End Products, Advanced ; Gonadal Steroid Hormones
    Language English
    Publishing date 2016-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2016.08.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction-Signatures of the internal exposome.

    Daiber, Andreas / Kröller-Schön, Swenja / Frenis, Katie / Oelze, Matthias / Kalinovic, Sanela / Vujacic-Mirski, Ksenija / Kuntic, Marin / Bayo Jimenez, Maria Teresa / Helmstädter, Johanna / Steven, Sebastian / Korac, Bato / Münzel, Thomas

    BioFactors (Oxford, England)

    2019  Volume 45, Issue 4, Page(s) 495–506

    Abstract: Environmental noise is a well-recognized health risk and part of the external exposome ... a disruption of sleep and communication leading to annoyance and subsequent sympathetic and endocrine stress ... of the nonauditory noise-induced cardiovascular and metabolic consequences, focusing on mental stress ...

    Abstract Environmental noise is a well-recognized health risk and part of the external exposome-the World Health Organization estimates that 1 million healthy life years are lost annually in Western Europe alone due to noise-related complications, including increased incidence of hypertension, heart failure, myocardial infarction, and stroke. Previous data suggest that noise works through two paired pathways in a proposed reaction model for noise exposure. As a nonspecific stressor, chronic low-level noise exposure can cause a disruption of sleep and communication leading to annoyance and subsequent sympathetic and endocrine stress responses leading to increased blood pressure, heart rate, stress hormone levels, and in particular more oxidative stress, being responsible for vascular dysfunction and representing changes of the internal exposome. Chronic stress generates cardiovascular risk factors on its own such as increased blood pressure, blood viscosity, blood glucose, and activation of blood coagulation. To this end, persistent chronic noise exposure increases cardiometabolic diseases, including arterial hypertension, coronary artery disease, arrhythmia, heart failure, diabetes mellitus type 2, and stroke. The present review discusses the mechanisms of the nonauditory noise-induced cardiovascular and metabolic consequences, focusing on mental stress signaling pathways, activation of the hypothalamic-pituitary-adrenocortical axis and sympathetic nervous system, the association of these activations with inflammation, and the subsequent onset of oxidative stress and vascular dysfunction. © 2019 BioFactors, 45 (4):495-506, 2019.
    MeSH term(s) Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/physiopathology ; Blood Coagulation/drug effects ; Blood Glucose/drug effects ; Blood Pressure/drug effects ; Blood Viscosity/drug effects ; Coronary Artery Disease/chemically induced ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/physiopathology ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Environmental Pollutants/adverse effects ; Exposome ; Heart Failure/chemically induced ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Hypertension/chemically induced ; Hypertension/metabolism ; Hypertension/physiopathology ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Oxidative Stress/drug effects ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology ; Stroke/chemically induced ; Stroke/metabolism ; Stroke/physiopathology ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology
    Chemical Substances Blood Glucose ; Environmental Pollutants
    Language English
    Publishing date 2019-04-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1506
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top