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  1. Article: Disturbed Mg++ transporters in hypertension.

    Kisters, Klaus / Gremmler, Bernhard / Hausberg, Martin

    Journal of hypertension

    2008  Volume 26, Issue 12, Page(s) 2450; author reply 2450–1

    MeSH term(s) Animals ; Calcium/metabolism ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Hypertension/metabolism ; Magnesium/metabolism ; Magnesium Deficiency/complications ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Mice ; Rats ; Rats, Inbred SHR ; TRPM Cation Channels/metabolism
    Chemical Substances TRPM Cation Channels ; TRPM6 protein, rat ; Trpm7 protein, rat (EC 2.7.11.1) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Letter
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0b013e3283154d7f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
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  2. Article: Mechanisms of hepatic microcirculatory disturbances induced by acute ethanol administration in rats, with special reference to alterations of sinusoidal endothelial fenestrae.

    Takashimizu, S / Watanabe, N / Nishizaki, Y / Kawazoe, K / Matsuzaki, S

    Alcoholism, clinical and experimental research

    1999  Volume 23, Issue 4 Suppl, Page(s) 39S–46S

    Abstract: ... into the portal vein via the mesenteric vein branch of rats as a continuous infusion (4 and 8 mg/min of ethanol) for 60 ... increase by approximately 1.5 cm H2O at 60 min. Ethanol concentrations in blood at 60 min after 4 and 8 mg ... min of ethanol infusion were 0.75 mg/ml and 1.77 mg/ml, respectively. At this point ...

    Abstract Elucidation of the hepatic hemodynamics in acute ethanol administration is an issue of clinical importance for better understanding of alcoholic liver diseases. The purpose of this study is to clarify the mechanism of hepatic microcirculatory disturbances after acute ethanol administration, especially regarding the effects of ethanol on alterations of sinusoidal endothelial fenestrae (SEF) and the involvement of endothelin-1 (ET-1) in the mechanism of portal hypertension induced by ethanol. Ethanol was administrated into the portal vein via the mesenteric vein branch of rats as a continuous infusion (4 and 8 mg/min of ethanol) for 60 min. Hepatic tissue blood flow measured with a laser Doppler blood flowmeter was found to be remarkably decreased with time, whereas portal pressure began to increase at 10 min and showed a significant increase by approximately 1.5 cm H2O at 60 min. Ethanol concentrations in blood at 60 min after 4 and 8 mg/min of ethanol infusion were 0.75 mg/ml and 1.77 mg/ml, respectively. At this point, scanning electron microscopy revealed significant decreases in number and diameter of SEF both in zone 1 and zone 3, with the increase in ethanol level. These findings suggested that decreases in number and diameter of SEF, whether primary or secondary, may lead to the impairment of the transport of plasma substances from sinusoids to hepatocytes in acute ethanol administration. Furthermore, the pretreatment of BQ-123 inhibited a decrease in hepatic tissue blood flow and an increase in portal pressure caused by ethanol, indicating that ET-1 may be involved in the mechanism of hepatic circulatory disturbances in acute ethanol administration.
    MeSH term(s) Animals ; Antihypertensive Agents/pharmacology ; Blood Flow Velocity ; Endothelin Receptor Antagonists ; Endothelin-1/physiology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/ultrastructure ; Ethanol/administration & dosage ; Ethanol/adverse effects ; Ethanol/blood ; Hypertension, Portal/chemically induced ; Infusions, Intravenous ; Liver/blood supply ; Male ; Mesenteric Veins ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Peptides, Cyclic/pharmacology ; Portal Vein/drug effects ; Rats ; Rats, Wistar ; Receptor, Endothelin A ; Venous Pressure
    Chemical Substances Antihypertensive Agents ; Endothelin Receptor Antagonists ; Endothelin-1 ; Peptides, Cyclic ; Receptor, Endothelin A ; Ethanol (3K9958V90M) ; cyclo(Trp-Asp-Pro-Val-Leu) (S2A8YZM151)
    Language English
    Publishing date 1999-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 428999-7
    ISSN 1530-0277 ; 0145-6008
    ISSN (online) 1530-0277
    ISSN 0145-6008
    DOI 10.1111/j.1530-0277.1999.tb04532.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.

    Buhl, Esben S / Jessen, Niels / Pold, Rasmus / Ledet, Thomas / Flyvbjerg, Allan / Pedersen, Steen B / Pedersen, Oluf / Schmitz, Ole / Lund, Sten

    Diabetes

    2002  Volume 51, Issue 7, Page(s) 2199–2206

    Abstract: ... subcutaneously injected with AICAR (0.5 mg/g body wt) daily for 7 weeks. Obese control rats were either pair-fed (PF) (n ... Zucker (fa/fa) rats (n = 6) exhibiting insulin resistance, hyperlipidemia, and hypertension were ... expression and to increase maximally insulin-stimulated glucose transport in primarily white fast-twitch ...

    Abstract The insulin resistance syndrome is characterized by several risk factors for cardiovascular disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enzymes in skeletal muscles, and decrease the content of intra-abdominal fat. Furthermore, acute AICAR exposure has been found to reduce sterol and fatty acid synthesis in rat hepatocytes incubated in vitro as well as suppress endogenous glucose production in rats under euglycemic clamp conditions. To investigate whether chronic AICAR administration, in addition to the beneficial effects on insulin sensitivity, is capable of improving other phenotypes associated with the insulin resistance syndrome, obese Zucker (fa/fa) rats (n = 6) exhibiting insulin resistance, hyperlipidemia, and hypertension were subcutaneously injected with AICAR (0.5 mg/g body wt) daily for 7 weeks. Obese control rats were either pair-fed (PF) (n = 6) or ad libitum-fed (AL) (n = 6). Lean Zucker rats (fa/-) (n = 8) served as a reference group. AICAR administration significantly reduced plasma triglyceride levels (P < 0.01 for AICAR vs. AL, and P = 0.05 for AICAR vs. PF) and free fatty acids (P < 0.01 for AICAR vs. AL, and P < 0.05 for AICAR vs. PF) and increased HDL cholesterol levels (P < 0.01 for AICAR vs. AL and PF). AICAR treatment also lowered systolic blood pressure by 14.6 +/- 4.3 mmHg (P < 0.05), and AICAR-treated animals exhibited a tendency toward decreased intra-abdominal fat content. Furthermore, AICAR administration normalized the oral glucose tolerance test and decreased fasting concentrations of glucose and insulin close to the level of the lean animals. Finally, in line with previous findings, AICAR treatment was also found to enhance GLUT4 protein expression and to increase maximally insulin-stimulated glucose transport in primarily white fast-twitch muscles. Our data provide strong evidence that long-term administration of AICAR improves glucose tolerance, improves the lipid profile, and reduces systolic blood pressure in an insulin-resistant animal model. The present study gives additional support to the hypothesis that AMPK activation might be a potential future pharmacological strategy for treating the insulin resistance syndrome.
    MeSH term(s) 3-O-Methylglucose/pharmacokinetics ; Adenylate Kinase/metabolism ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Blood Glucose/metabolism ; Blood Pressure/drug effects ; Glucose Clamp Technique ; Glucose Transporter Type 4 ; Hypertension/drug therapy ; Insulin Resistance/physiology ; Male ; Metabolic Syndrome ; Monosaccharide Transport Proteins/drug effects ; Monosaccharide Transport Proteins/metabolism ; Muscle Proteins ; Rats ; Rats, Zucker ; Ribonucleotides/pharmacology ; Syndrome
    Chemical Substances Blood Glucose ; Glucose Transporter Type 4 ; Monosaccharide Transport Proteins ; Muscle Proteins ; Ribonucleotides ; Slc2a4 protein, rat ; 3-O-Methylglucose (146-72-5) ; Aminoimidazole Carboxamide (360-97-4) ; Adenylate Kinase (EC 2.7.4.3) ; AICA ribonucleotide (F0X88YW0YK)
    Language English
    Publishing date 2002-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/diabetes.51.7.2199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.175: Show issues Location:
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  4. Article: Disturbances of renal and erythrocyte calcium handling in rats of the Milan hypertensive strain.

    Cirillo, M / Galletti, F / Corrado, M F / Strazzullo, P

    Journal of hypertension

    1986  Volume 4, Issue 4, Page(s) 443–449

    Abstract: ... in Na handling. Adenosine triphosphate (ATP)-dependent Ca transport, reflecting the Ca, magnesium (Mg ... suggest that in MHS, Ca reabsorption in the renal tubular cell is reduced independently of disturbances ... clear whether the disturbances of renal and erythrocyte Ca handling were a genetic primary defect or ...

    Abstract Urinary calcium (Ca) excretion and erythrocyte membrane Ca binding and transport were investigated in rats of the Milan hypertensive (MHS) and normotensive strains (MNS). Despite slightly reduced ionized Ca levels in the serum, MHS significantly increased urinary Ca excretion under fasting conditions (P less than 0.01). Urinary Ca was positively related to sodium (Na) excretion in both rat strains; moreover the urinary Ca:Na ratio was significantly enhanced in MHS rats (P less than 0.05). These data suggest that in MHS, Ca reabsorption in the renal tubular cell is reduced independently of disturbances in Na handling. Adenosine triphosphate (ATP)-dependent Ca transport, reflecting the Ca, magnesium (Mg)-ATPase activity (Ca pump), was measured in inside-out vesicles obtained from erythrocyte membranes. This variable was significantly reduced in MHS (P less than 0.01), with no change in the Ca pump affinity constant for Ca. Calcium binding to erythrocyte membranes, measured in the presence of free Ca concentrations comparable with those of the intracellular fluid, was found to be significantly reduced (P less than 0.01) in MHS rats because of the lower number of Ca binding sites. These abnormalities of red blood cell (RBC) Ca handling are in keeping with the increased Ca clearance observed in the kidney. It is not clear whether the disturbances of renal and erythrocyte Ca handling were a genetic primary defect or a secondary change of membrane function.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Biological Transport, Active ; Calcium/metabolism ; Cell Membrane/metabolism ; Erythrocytes/metabolism ; Hypertension/genetics ; Hypertension/metabolism ; Kidney/metabolism ; Kinetics ; Male ; Rats ; Rats, Inbred SHR
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1986-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/00004872-198608000-00008
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  5. Article ; Online: Incident prediabetes/diabetes and blood pressure in urban and rural communities in the Democratic Republic of Congo.

    Hightower, Joyce D / Hightower, C Makena / Vázquez, Beatriz Y Salazar / Intaglietta, Marcos

    Vascular health and risk management

    2011  Volume 7, Page(s) 483–489

    Abstract: ... 29.3 mg/dL and 95.4 ± 27.8 mg/dL, respectively), were significantly reduced compared ... with the transitional (122.1 ± 19.4 mg/dL and 122.8 ± 23.9 mg/dL), and modern (118.8 ± 15.9 mg/dL and 114.1 ± 17.1 mg/dL ... designed as a low-cost determination of the prevalence of incident prediabetes/diabetes in the DRC ...

    Abstract Background: The Democratic Republic of Congo (DRC) faces increased morbidity and mortality due to treatable and preventable noncommunicable diseases. However, it continues to struggle with political and economic instability, which impedes much needed health infrastructure improvements. The present study was designed as a low-cost determination of the prevalence of incident prediabetes/diabetes in the DRC.
    Method: Fasting blood glucose, body mass index, blood pressure, and age were assessed in adult participants in health screenings conducted throughout urban and rural DRC. Communities were divided into three categories, based on physical activity (means of transport) and diet, ie, traditional (nonmotorized transport and vegetable/starch-based diets); transitional (incorporating traditional practices with motorized transport) and modern (motorized transport and protein/ processed foods). Fasting blood glucose and blood pressure were established using finger prick blood samples and monitors approved by the US Food and Drug Administration.
    Results: The prevalence of incident prediabetes/diabetes was over 47% for the traditional population, 88.6% for the transitional population, and 91.4% for the modern communities. Fasting blood glucose levels analyzed through an analysis of covariance, with age and body mass index as covariates, demonstrated that fasting blood glucose levels of male and female subgroups in the traditional community (101.8 ± 29.3 mg/dL and 95.4 ± 27.8 mg/dL, respectively), were significantly reduced compared with the transitional (122.1 ± 19.4 mg/dL and 122.8 ± 23.9 mg/dL), and modern (118.8 ± 15.9 mg/dL and 114.1 ± 17.1 mg/dL) populations. Additionally, for the male and female subgroups, logistic regression analysis confirmed a significant association between incident prediabetes/diabetes, fasting blood glucose, diet, and level of physical activity.
    Conclusion: There is a higher than expected prevalence of incident prediabetes/diabetes in the DRC adult population, without a clear association with risk factors pertaining to diet, level of physical activity, body mass index, and blood pressure. The substantial morbidity and mortality associated with diabetes highlights the critical need for further and more precise diabetic diagnostic testing throughout the DRC.
    MeSH term(s) Adult ; Blood Glucose/analysis ; Blood Pressure ; Body Mass Index ; Democratic Republic of the Congo/epidemiology ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Diet/adverse effects ; Exercise ; Fasting/blood ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Life Style ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2011-07-22
    Publishing country New Zealand
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186568-1
    ISSN 1178-2048 ; 1176-6344
    ISSN (online) 1178-2048
    ISSN 1176-6344
    DOI 10.2147/VHRM.S22707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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