Article: Effect of avian influenza virus infection on the phagocytic function of systemic phagocytes and pulmonary macrophages of turkeys.
1994 Volume 38, Issue 1, Page(s) 93–102
Abstract: The effects of avian influenza virus (AIV) infection on systemic phagocytes and ... pulmonary macrophages correlated with the peak virus titer in the lungs and trachea of AIV-inoculated inoculated turkeys ... Bacterial killing by pulmonary macrophages from AIV-inoculated turkeys was reduced on days 6 and 10 PI ...
| Abstract | The effects of avian influenza virus (AIV) infection on systemic phagocytes and pulmonary macrophages of turkeys were studied. There was a significant increase (P < 0.0001) in oxidative burst in systemic phagocytes of AIV-inoculated turkeys on 2, 4, 6, and 8 days postinoculation (PI), as measured by chemiluminescence. There was also a significant increase (P < 0.02) in oxidative burst in pulmonary macrophages on day 4 PI. The chemiluminescence response was depressed on 6, 8, and 10 days PI in AIV-inoculated turkeys compared with controls. The increase in oxidative response in both systemic phagocytes and pulmonary macrophages correlated with the peak virus titer in the lungs and trachea of AIV-inoculated inoculated turkeys. Bacterial killing by pulmonary macrophages from AIV-inoculated turkeys was reduced on days 6 and 10 PI compared with uninoculated controls. Histopathological changes in trachea were more pronounced on day 6 PI in AIV-inoculated turkeys; no significant changes were detected in the lungs. These data indicate that compromised functional capacity of pulmonary macrophages predisposes turkeys to secondary bacterial infections. |
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| MeSH term(s) | Animals ; Cell Separation ; Cells, Cultured ; Chick Embryo ; Escherichia coli ; Influenza A virus/growth & development ; Influenza A virus/isolation & purification ; Influenza in Birds/pathology ; Influenza in Birds/physiopathology ; Luminescent Measurements ; Lung/pathology ; Macrophages, Alveolar/physiology ; Mucous Membrane/pathology ; Phagocytes/physiology ; Phagocytosis ; Trachea/pathology ; Turkeys |
| Language | English |
| Publishing date | 1994-01 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 40871-2 |
| ISSN | 1938-4351 ; 0005-2086 |
| ISSN (online) | 1938-4351 |
| ISSN | 0005-2086 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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