Article: Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons.
1996 Volume 68, Issue 1-2, Page(s) 101–108
Abstract: ... Thus, IFN-gamma induced type I NOS activity may play an important role in host immunity against neurotropic ... gamma induced type I NOS and antagonized by NOS inhibitors. In contrast, while IFN-gamma treatment ... gamma treatment of NB41A3 cells increased NO production and type I NOS protein. In vitro replication ...
| Abstract | Type I NOS expression increases in OB neurons during VSV infection. Immunocytochemical staining of NB41A3 cells indicates constitutive expression of interferon (IFN)-gamma receptor and type I NOS. IFN-gamma treatment of NB41A3 cells increased NO production and type I NOS protein. In vitro replication of VSV, polio virus type I, and Herpes Simplex virus type I (HSV-1) is significantly inhibited by IFN-gamma induced type I NOS and antagonized by NOS inhibitors. In contrast, while IFN-gamma treatment inhibited influenza and Sindbis virus replication, a different pathway(s) was involved. The isoform-selective NOS inhibitor. 7-nitroindazole (7NI) was used to treat mice, resulting in a 10-fold higher titer of virus in brain homogenates, and abrogated the recovery-promoting effect of interleukin-12 treatment. Thus, IFN-gamma induced type I NOS activity may play an important role in host immunity against neurotropic viral infections. |
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| MeSH term(s) | Animals ; Astrocytoma ; Base Sequence ; Herpesvirus 1, Human/physiology ; Interferon-gamma/pharmacology ; Macrophages/enzymology ; Macrophages/immunology ; Mice ; Molecular Sequence Data ; Neuroblastoma ; Neurons/chemistry ; Neurons/enzymology ; Neurons/virology ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase/immunology ; Nitric Oxide Synthase/metabolism ; Poliovirus/physiology ; Receptors, Interferon/analysis ; Tumor Cells, Cultured/enzymology ; Tumor Cells, Cultured/immunology ; Up-Regulation/immunology ; Vesicular stomatitis Indiana virus/physiology ; Virus Replication | |||||
| Chemical Substances | Receptors, Interferon ; Nitric Oxide (31C4KY9ESH) ; Interferon-gamma (82115-62-6) ; Nitric Oxide Synthase (EC 1.14.13.39) | |||||
| Language | English | |||||
| Publishing date | 1996-08 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. | |||||
| ZDB-ID | 8335-5 | |||||
| ISSN | 1872-8421 ; 0165-5728 | |||||
| ISSN (online) | 1872-8421 | |||||
| ISSN | 0165-5728 | |||||
| DOI | 10.1016/0165-5728(96)00083-5 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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