Article: Role of IgM antibodies versus B cells in influenza virus-specific immunity.
European journal of immunology
2002 Volume 32, Issue 8, Page(s) 2229–2236
Abstract: ... and a role of both IgM and IgG antibodies in the defense against acute influenza virus infection. ... We have compared the role of IgM antibodies with the role of B cells in control of primary ... influenza virus infection. Mice deficient in IgM (IgM(-/-)), but capable of producing other Igisotypes, exhibited ...
| Abstract | We have compared the role of IgM antibodies with the role of B cells in control of primary influenza virus infection. Mice deficient in IgM (IgM(-/-)), but capable of producing other Igisotypes, exhibited increased pulmonary virus titers compared to wild-type mice. However, IgM(-/-) mice were less susceptible compared to B cell-deficient micro MT) mice. CD4(+) T cells from spleen and lung draining lymph nodes of infected micro MT mice showed reduced proliferation upon virus re-stimulation in vitro. Furthermore, numbers of IFN-gamma-producing CD4(+) effector T cells were reduced in the alveolar lavage (BAL) of micro MT mice but not IgM(-/-) mice. In contrast, total number of virus-specific CTL was almost comparable in BAL of micro MT and wild-type mice. Pulmonary recruitment of inflammatory macrophages and neutrophils occurred normally in both micro MT and IgM(-/-) mice. Interestingly, virus-specific IgG2a and IgG2b antibody responses were affected locally in the BAL and in the serum of IgM(-/-) mice, while IgG1 responses remained largely normal. Taken together, our data suggest a role for B cells to promote effector T cell responses and a role of both IgM and IgG antibodies in the defense against acute influenza virus infection. |
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| MeSH term(s) | Animals ; Antibodies, Viral/blood ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Lung/immunology ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae/immunology | ||||||||||
| Chemical Substances | Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2002-08 | ||||||||||
| Publishing country | Germany | ||||||||||
| Document type | Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 120108-6 | ||||||||||
| ISSN | 1521-4141 ; 0014-2980 | ||||||||||
| ISSN (online) | 1521-4141 | ||||||||||
| ISSN | 0014-2980 | ||||||||||
| DOI | 10.1002/1521-4141(200208)32:8<2229::AID-IMMU2229>3.0.CO;2-T | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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