Article ; Online: Multi-inflammatory syndrome and Kawasaki disease in children during the COVID-19 pandemic: A nationwide register-based study and time series analysis.
Acta paediatrica (Oslo, Norway : 1992)
2021 Volume 110, Issue 11, Page(s) 3063–3068
Abstract: ... infections in children. Our time series analysis showed that Kawasaki disease cases decreased during ... of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C).: Methods: This national ... coronavirus 2 (SARS-CoV-2) infections, MIS-C and Kawasaki disease cases. We performed a time series analysis ...
| Abstract | Aim: We investigated whether the ongoing COVID-19 pandemic was associated with the occurrence of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C). Methods: This national Finnish register-based study was based on laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, MIS-C and Kawasaki disease cases. We performed a time series analysis on the occurrence of Kawasaki disease in 2016-2020. Results: In 2020, there were 5170 laboratory-confirmed COVID-19 cases in children under 18 years of age and five fulfilled the MIS-C case definition. The occurrence of MIS-C was 0.97 per 1000 (95% confidence interval: 0.31-2.26) laboratory-confirmed SARS-CoV-2 infections in children. Our time series analysis showed that Kawasaki disease cases decreased during the COVID-19 pandemic. The seasonally adjusted incidence rate ratio was 0.49 (95% confidence interval: 0.32-0.74) when it was compared to pre-pandemic levels. This coincided with a reduced occurrence of respiratory infections, due to social distancing in the population. Conclusion: This nationwide register-based study found that MIS-C was a rare complication of the SARS-CoV-2 infection. The occurrence of Kawasaki disease and respiratory infections decreased during the pandemic. This suggests that transmissible microbes may play an important role in Kawasaki disease and social distancing may have a protective effect. |
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| MeSH term(s) | Adolescent ; COVID-19/complications ; COVID-19/epidemiology ; Child ; Finland/epidemiology ; Humans ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Pandemics ; Systemic Inflammatory Response Syndrome | |||||
| Language | English | |||||
| Publishing date | 2021-08-04 | |||||
| Publishing country | Norway | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 203487-6 | |||||
| ISSN | 1651-2227 ; 0365-1436 ; 0803-5253 | |||||
| ISSN (online) | 1651-2227 | |||||
| ISSN | 0365-1436 ; 0803-5253 | |||||
| DOI | 10.1111/apa.16051 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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