Article ; Online: Association of the ABO blood group with SARS-CoV-2 infection in a community with low infection rate.
2021 Volume 116, Issue 8, Page(s) 910–915
Abstract: ... the possible association between SARS-CoV-2 infection and the ABO phenotype in Black Africa.: Materials and ... by the SARS-CoV-2 virus have mostly come from countries with high infection rates. This study examined ... likely reasons for the lower infectivity by the SARS-CoV-2 virus and severity of COVID-19 disease ...
| Abstract | Background and objectives: Reports on the association of the ABO phenotypes with infection by the SARS-CoV-2 virus have mostly come from countries with high infection rates. This study examined the possible association between SARS-CoV-2 infection and the ABO phenotype in Black Africa. Materials and methods: This report is from a single centre where both asymptomatic and symptomatic patients were quarantined. At the time of this report, Oyo State, Nigeria had carried out 15 733 tests of which 3119 were positive for the virus with 1952 recoveries and 37 deaths. The ABO distribution of patients was compared with that of a blood donor population. Results: Of the 302 participants, 297 (98%) had their blood group determined, asymptomatic and symptomatic individuals were 123 (40·7%) and 179 (59·3%) respectively. Blood group O was significantly less represented among the patients (P < 0·01) while blood groups B and AB were significantly more represented (P < 0·01, P = 0·03 respectively). Patients with anti-B (groups A and O) were significantly less represented than those without anti-B (B and/or AB): B and AB (P < 0·001), B (P = 0·002), AB (P = 0·01). There was no difference in the blood group distribution of symptomatic and asymptomatic patients (χ Conclusion: The higher prevalence of blood group O and more potent beta haemolysins (anti-B antibodies) are likely reasons for the lower infectivity by the SARS-CoV-2 virus and severity of COVID-19 disease in the community. |
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| MeSH term(s) | ABO Blood-Group System ; Blood Donors ; COVID-19 ; Humans ; SARS-CoV-2 | |||||
| Chemical Substances | ABO Blood-Group System | |||||
| Language | English | |||||
| Publishing date | 2021-02-02 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 80313-3 | |||||
| ISSN | 1423-0410 ; 0042-9007 | |||||
| ISSN (online) | 1423-0410 | |||||
| ISSN | 0042-9007 | |||||
| DOI | 10.1111/vox.13077 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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