Article ; Online: Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05.
Bulletin of experimental biology and medicine
2012 Volume 153, Issue 2, Page(s) 229–232
Abstract: C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05 ... inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was ... The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized ...
| Abstract | C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination. |
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| MeSH term(s) | Animals ; Cathepsin D/metabolism ; Disease Models, Animal ; Fas-Associated Death Domain Protein/metabolism ; Influenza A Virus, H5N1 Subtype/isolation & purification ; Interleukin-6/metabolism ; Lung/immunology ; Lung/pathology ; Lung/virology ; Macrophages, Alveolar/cytology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/virology ; Male ; Mice ; Mice, Inbred C57BL ; Muramidase/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/pathology ; Orthomyxoviridae Infections/virology ; Peroxidase/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Tumor Necrosis Factor-alpha/metabolism | |||||
| Chemical Substances | Fadd protein, mouse ; Fas-Associated Death Domain Protein ; Interleukin-6 ; TNF-Related Apoptosis-Inducing Ligand ; Tnfsf10 protein, mouse ; Tumor Necrosis Factor-alpha ; Peroxidase (EC 1.11.1.7) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Muramidase (EC 3.2.1.17) ; Cathepsin D (EC 3.4.23.5) | |||||
| Language | Russian | |||||
| Publishing date | 2012-07-01 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 390407-6 | |||||
| ISSN | 1573-8221 ; 0007-4888 ; 0365-9615 | |||||
| ISSN (online) | 1573-8221 | |||||
| ISSN | 0007-4888 ; 0365-9615 | |||||
| DOI | 10.1007/s10517-012-1683-y | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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