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  1. Article ; Online: Heparan sulfate is required for embryonic stem cells to exit from self-renewal.

    Kraushaar, Daniel C / Yamaguchi, Yu / Wang, Lianchun

    The Journal of biological chemistry

    2015  Volume 290, Issue 38, Page(s) 23023

    Language English
    Publishing date 2015-09-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.A109.066837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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  2. Article ; Online: Heparan sulfate is required for embryonic stem cells to exit from self-renewal.

    Kraushaar, Daniel C / Yamaguchi, Yu / Wang, Lianchun

    The Journal of biological chemistry

    2009  Volume 285, Issue 8, Page(s) 5907–5916

    Abstract: Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-renewal and ... lineage commitment at each division during continuous proliferation. Heparan sulfate (HS) is a highly ... the role of HS in ESC self-renewal by examining Ext1(-/-) ESCs that are deficient in HS. We found that Ext1 ...

    Abstract Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-renewal and lineage commitment at each division during continuous proliferation. Heparan sulfate (HS) is a highly sulfated polysaccharide and is present abundantly on the ESC surface. In this study, we investigated the role of HS in ESC self-renewal by examining Ext1(-/-) ESCs that are deficient in HS. We found that Ext1(-/-) ESCs retained their self-renewal potential but failed to transit from self-renewal to differentiation upon removal of leukemia inhibitory factor. Furthermore, we found that the aberrant cell fate commitment is caused by defects in fibroblast growth factor signaling, which directly retained high expression of the pluripotency gene Nanog in Ext1(-/-) ESCs. Therefore, our studies identified and defined HS as a novel factor that controls ESC fate commitment and also delineates that HS facilitates fibroblast growth factor signaling, which, in turn, inhibits Nanog expression and commits ESCs to lineage differentiation.
    MeSH term(s) Animals ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Proliferation ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Fibroblast Growth Factors/pharmacology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Heparitin Sulfate/biosynthesis ; Heparitin Sulfate/genetics ; Homeodomain Proteins/biosynthesis ; Homeodomain Proteins/genetics ; Leukemia Inhibitory Factor/pharmacology ; Mice ; Mice, Transgenic ; N-Acetylglucosaminyltransferases/genetics ; N-Acetylglucosaminyltransferases/metabolism ; Nanog Homeobox Protein ; Signal Transduction/drug effects ; Signal Transduction/physiology
    Chemical Substances Homeodomain Proteins ; Leukemia Inhibitory Factor ; Lif protein, mouse ; Nanog Homeobox Protein ; Nanog protein, mouse ; Fibroblast Growth Factors (62031-54-3) ; Heparitin Sulfate (9050-30-0) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; exostosin-1 (EC 2.4.1.224)
    Language English
    Publishing date 2009-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M109.066837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Heparan Sulfate Is Required for Embryonic Stem Cells to Exit from Self-renewal

    Kraushaar, Daniel C / Yamaguchi, Yu / Wang, Lianchun

    Journal of biological chemistry. 2010 Feb. 19, v. 285, no. 8

    2010  

    Abstract: Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-renewal and ... lineage commitment at each division during continuous proliferation. Heparan sulfate (HS) is a highly ... the role of HS in ESC self-renewal by examining Ext1⁻/⁻ ESCs that are deficient in HS. We found that Ext1⁻ ...

    Abstract Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-renewal and lineage commitment at each division during continuous proliferation. Heparan sulfate (HS) is a highly sulfated polysaccharide and is present abundantly on the ESC surface. In this study, we investigated the role of HS in ESC self-renewal by examining Ext1⁻/⁻ ESCs that are deficient in HS. We found that Ext1⁻/⁻ ESCs retained their self-renewal potential but failed to transit from self-renewal to differentiation upon removal of leukemia inhibitory factor. Furthermore, we found that the aberrant cell fate commitment is caused by defects in fibroblast growth factor signaling, which directly retained high expression of the pluripotency gene Nanog in Ext1⁻/⁻ ESCs. Therefore, our studies identified and defined HS as a novel factor that controls ESC fate commitment and also delineates that HS facilitates fibroblast growth factor signaling, which, in turn, inhibits Nanog expression and commits ESCs to lineage differentiation.
    Language English
    Dates of publication 2010-0219
    Size p. 5907-5916.
    Publishing place American Society for Biochemistry and Molecular Biology
    Document type Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database NAL-Catalogue (AGRICOLA)

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