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  1. Article ; Online: Cardiac Abnormalities in COVID-19 and Relationship to Outcome.

    Krishna, Hema / Ryu, Alexander J / Scott, Christopher G / Mandale, Deepa R / Naqvi, Tasneem Z / Pellikka, Patricia A

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 932–942

    Abstract: ... such abnormalities to the COVID-19 infection in this comorbid patient population. ... outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19).: Methods: Retrospective ... motion abnormalities in 26 (15%), and right ventricular systolic pressure (RVSP) of 35 or greater mm Hg ...

    Abstract Objective: To characterize the clinical and transthoracic echocardiographic features and 30-day outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19).
    Methods: Retrospective cohort study that included consecutive inpatients with COVID-19 infection who underwent clinically indicated transthoracic echocardiography at 10 sites in the Mayo Clinic Health System between March 10 and August 5, 2020. Echocardiography was performed at bedside by cardiac sonographers according to an abbreviated protocol. Echocardiographic results, demographic characteristics, laboratory findings, and clinical outcomes were analyzed.
    Results: There were 179 patients, aged 59.8±16.9 years and 111 (62%) men; events within 30 days occurred in 70 (39%) patients, including prolonged hospitalization in 43 (24%) and death in 27 (15%). Echocardiographic abnormalities included left ventricular ejection fraction less than 50% in 29 (16%), regional wall motion abnormalities in 26 (15%), and right ventricular systolic pressure (RVSP) of 35 or greater mm Hg in 44 (44%) of 101 in whom it was measured. Myocardial injury, defined as the presence of significant troponin level elevation accompanied by new ventricular dysfunction or electrocardiographic abnormalities, was present in 13 (7%). Prior echocardiography was available in 36 (20%) patients and pre-existing abnormalities were seen in 28 (78%) of these. In a multivariable age-adjusted model, area under the curve of 0.81, prior cardiovascular disease, troponin level, D-dimer level, and RVSP were related to events at 30 days.
    Conclusion: Bedside Doppler assessment of RVSP appears promising for short-term risk stratification in hospitalized patients with COVID-19 infection undergoing clinically indicated echocardiography. Pre-existing echocardiographic abnormalities were common; caution should be exercised in attributing such abnormalities to the COVID-19 infection in this comorbid patient population.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Echocardiography ; Female ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Heart Diseases/therapy ; Hospitalization ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Retrospective Studies ; Stroke Volume
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.01.006
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  2. Article ; Online: Cardiac Complications and COVID-19: A Review of Life-threatening Co-morbidities.

    Eftekhar, Zeinab / Haybar, Habib / Mohebbi, Alireza / Saki, Najmaldin

    Current cardiology reviews

    2024  

    Abstract: ... outcomes, extended hospitalization time, and increased mortality rate. Patients with COVID-19 and CVDs are ... and retrieved from the Google Scholar search engine and PubMed database up to 2023 using COVID-19 ... remarkable inflammatory markers. Moreover, studies have linked cardiac complications in COVID-19 with poor ...

    Abstract The novel 2019 coronavirus disease (COVID-19) was first reported in the last days of December 2019 in Wuhan, China. The presence of certain co-morbidities, including cardiovascular diseases (CVDs), are the basis for worse outcomes in patients with COVID-19. Relevant English-language literature was searched and retrieved from the Google Scholar search engine and PubMed database up to 2023 using COVID-19, SARS-CoV-2, Heart failure, Myocardial infarction, and Arrhythmia and Cardiac complication as keywords. Increased hemodynamic load, ischemia-related dysfunction, ventricular remodeling, excessive neurohumoral stimulation, abnormal myocyte calcium cycling, and excessive or insufficient extracellular matrix proliferation are associated with heart failure (HF) in COVID-19 patients. Inflammatory reaction due to the excessive release of inflammatory cytokines, leads to myocardial infarction (MI) in these patients. The virus can induce heart arrhythmia through cardiac complications, hypoxia, decreased heart hemodynamics, and remarkable inflammatory markers. Moreover, studies have linked cardiac complications in COVID-19 with poor outcomes, extended hospitalization time, and increased mortality rate. Patients with COVID-19 and CVDs are at higher mortality risk and they should be given high priority when receiving the treatment and intensive care during hospitalization.
    Language English
    Publishing date 2024-02-20
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/011573403X279782240206091322
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  3. Article ; Online: Multimodality Cardiac Imaging, Cardiac Symptoms, and Clinical Outcomes in Patients Who Recovered from Mild COVID-19.

    Hanneman, Kate / Houbois, Christian / Kei, Tiffanie / Gustafson, Dakota / Thampinathan, Babitha / Sooriyakanthan, Maala / Fish, Jason E / Howe, Kathryn L / Cheung, Angela M / Wintersperger, Bernd J / Gold, Wayne L / Woo, Anna / Thavendiranathan, Paaladinesh

    Radiology

    2023  Volume 308, Issue 1, Page(s) e230767

    Abstract: ... the relationship between multi-modality cardiac imaging parameters, symptoms, and clinical outcomes in patients ... recovered from mild COVID-19 compared to COVID-19 negative controls. Materials and Methods Patients ... females) and 22 COVID-19 negative controls (mean age, 46 years ± 16 [SD]; 13 females). At 3-6 months, 20 ...

    Abstract Background Many patients have persistent cardiac symptoms after mild COVID-19. However, studies assessing the relationship between symptoms and cardiac imaging are limited. Purpose To assess the relationship between multi-modality cardiac imaging parameters, symptoms, and clinical outcomes in patients recovered from mild COVID-19 compared to COVID-19 negative controls. Materials and Methods Patients who underwent PCR testing for SARS-CoV-2 between August 2020 and January 2022 were invited to participate in this prospective, single-center study. Participants underwent cardiac MRI, echocardiography, and assessment of cardiac symptoms at 3-6 months after SARS-CoV-2 testing. Cardiac symptoms and outcomes were also evaluated at 12-18 months. Statistical analysis included Fisher's exact test and logistic regression. Results This study included 122 participants who recovered from COVID-19 ([COVID+] mean age, 42 years ± 13 [SD]; 73 females) and 22 COVID-19 negative controls (mean age, 46 years ± 16 [SD]; 13 females). At 3-6 months, 20% (24/122) and 44% (54/122) of COVID+ participants had at least one abnormality on echocardiography and cardiac MRI, respectively, which did not differ compared to controls (23% [5/22];
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; COVID-19 Testing ; Prospective Studies ; COVID-19 ; SARS-CoV-2 ; Multimodal Imaging
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.230767
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  4. Article ; Online: Feature tracking cardiac magnetic resonance imaging to assess cardiac manifestations of systemic diseases.

    Pezeshki, Parmida Sadat / Ghorashi, Seyyed Mojtaba / Houshmand, Golnaz / Ganjparvar, Mojdeh / Pouraliakbar, Hamidreza / Rezaei-Kalantari, Kiara / Fazeli, Amir / Omidi, Negar

    Heart failure reviews

    2023  Volume 28, Issue 5, Page(s) 1189–1199

    Abstract: ... disease 2019 (COVID-19). We concluded that FT-CMR-derived strain can improve the accuracy of risk ... stratification and predict cardiac outcomes in patients with systemic diseases prior to symptomatic cardiac ... deformation, has a unique role in the evaluation of subclinical myocardial abnormalities. This review aimed ...

    Abstract Feature-tracking cardiac magnetic resonance (FT-CMR), with the ability to quantify myocardial deformation, has a unique role in the evaluation of subclinical myocardial abnormalities. This review aimed to evaluate the clinical use of cardiac FT-CMR-based myocardial strain in patients with various systemic diseases with cardiac involvement, such as hypertension, diabetes, cancer-therapy-related toxicities, amyloidosis, systemic scleroderma, myopathies, rheumatoid arthritis, thalassemia major, and coronavirus disease 2019 (COVID-19). We concluded that FT-CMR-derived strain can improve the accuracy of risk stratification and predict cardiac outcomes in patients with systemic diseases prior to symptomatic cardiac dysfunction. Furthermore, FT-CMR is particularly useful for patients with diseases or conditions which are associated with subtle myocardial dysfunction that may not be accurately detected with traditional methods. Compared to patients with cardiovascular diseases, patients with systemic diseases are less likely to undergo regular cardiovascular imaging to detect cardiac defects, whereas cardiac involvement in these patients can lead to major adverse outcomes; hence, the importance of cardiac imaging modalities might be underestimated in this group of patients. In this review, we gathered currently available data on the newly introduced role of FT-CMR in the diagnosis and prognosis of various systemic conditions. Further research is needed to define reference values and establish the role of this sensitive imaging modality, as a robust marker in predicting outcomes across a wide spectrum of patients.
    MeSH term(s) Humans ; Magnetic Resonance Imaging, Cine/methods ; Ventricular Function, Left ; Predictive Value of Tests ; COVID-19/complications ; Magnetic Resonance Imaging ; Reproducibility of Results
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-023-10321-6
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  5. Article ; Online: Cardiac MRI in patients with COVID-19 infection.

    Abdeldayem, Emad H / Raief Mosaad, Basant M / Yassin, Aya / Abdelrahman, Ahmed S

    European radiology

    2022  Volume 33, Issue 6, Page(s) 3867–3877

    Abstract: Objective: COVID-19 infection is a systemic disease with various cardiovascular symptoms and ... COVID-19-related cardiac injuries may cause similar clinical symptoms. Cardiac MRI is the modality ... outcome. • Cardiac MRI is the modality of choice to differentiate between the different aspects of COVID ...

    Abstract Objective: COVID-19 infection is a systemic disease with various cardiovascular symptoms and complications. Cardiac MRI with late gadolinium enhancement is the modality of choice for the assessment of myocardial involvement. T1 and T2 mapping can increase diagnostic accuracy and improve further management. Our study aimed to evaluate the different aspects of myocardial damage in cases of COVID-19 infection using cardiac MRI.
    Methods: This descriptive retrospective study included 86 cases, with a history of COVID-19 infection confirmed by positive RT-PCR, who met the inclusion criteria. Patients had progressive chest pain or dyspnoea with a suspected underlying cardiac cause, either by an abnormal electrocardiogram or elevated troponin levels. Cardiac MRI was performed with late contrast-enhanced (LGE) imaging, followed by T1 and T2 mapping.
    Results: Twenty-four patients have elevated hsTnT with a median hsTnT value of 133 ng/L (IQR: 102 to 159 ng/L); normal value < 14 ng/L. Other sixty-two patients showed elevated hsTnI with a median hsTnI value of 1637 ng/L (IQR: 1340 to 2540 ng/L); normal value < 40 ng/L. CMR showed 52 patients with acute myocarditis, 23 with Takotsubo cardiomyopathy, and 11 with myocardial infarction. Invasive coronary angiography was performed only in selected patients.
    Conclusion: Different COVID-19-related cardiac injuries may cause similar clinical symptoms. Cardiac MRI is the modality of choice to differentiate between the different types of myocardial injury such as Takotsubo cardiomyopathy and infection-related cardiomyopathy or even acute coronary syndrome secondary to vasculitis or oxygen-demand mismatch.
    Key points: • It is essential to detect early COVID-related cardiac injury using different cardiac biomarkers and cardiac imaging, as it has a significant impact on patient management and outcome. • Cardiac MRI is the modality of choice to differentiate between the different aspects of COVID-related myocardial injury.
    MeSH term(s) Humans ; Retrospective Studies ; Contrast Media ; COVID-19/complications ; Takotsubo Cardiomyopathy ; Gadolinium ; Magnetic Resonance Imaging/methods ; Myocarditis/complications ; Myocarditis/diagnostic imaging ; Predictive Value of Tests ; Magnetic Resonance Imaging, Cine/adverse effects
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2022-12-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-09325-x
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  6. Article ; Online: Cardiac Outcome of Children With SARS-CoV-2 Related Multisystem Inflammatory Syndrome.

    Ghodsi, Ali Reza / Malek, Abdolreza / Siroosbakht, Soheila / Aminian, Alireza / Dormanesh, Banafshe / Azarfar, Anoush / Zoshk, Mojtaba Yousefi

    Indian pediatrics

    2023  Volume 60, Issue 5, Page(s) 381–384

    Abstract: ... patients, and the most common cardiac abnormalities were valve failure (50.9%), followed ... by ventricular dysfunction (39.7%), and pericardial effusion (23.3%). Six month after diagnosis, cardiac abnormalities were ... included in the study. At the time of admission, cardiac abnormalities were present in 70.7% of MIS-C ...

    Abstract Objective: To study the cardiac outcomes of patients with multisystem inflammatory syndrome in children (MIS-C) after 6-month of diagnosis.
    Methods: This review of hospital records was conducted on MIS-C patients (aged <21 year) who completed a six-month follow up. The baseline demographic, clinical, laboratory, and treatment characteristics during the acute phase, and echocardiographic findings during follow-up were collected.
    Results: 116 patients (61.2% male, median age 7 years) with MIS-C were included in the study. At the time of admission, cardiac abnormalities were present in 70.7% of MIS-C patients, and the most common cardiac abnormalities were valve failure (50.9%), followed by ventricular dysfunction (39.7%), and pericardial effusion (23.3%). Six month after diagnosis, cardiac abnormalities were found in 10.3% of patients, and patients had lower rates of ventricular dysfunction (P<0.001), valve failure (P<0.001), pericardial effusion (P<0.001), and coronary involvement (P<0.001) as composed to the baseline. Intravenous immunoglobulin (IVIG) and steroid treatment significantly reduced the odds of occurrence of ventricular dysfunction (P=0.002), valve failure (P=0.004), and low ejection fraction (P=0.002) in comparison to IVIG treatment.
    Conclusion: While most MIS-C patients had abnormal echocardiographic findings at admission, only 10.3% of patients had cardiac abnormalities during follow up.
    MeSH term(s) Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/therapy ; COVID-19/diagnosis ; COVID-19/therapy ; Ventricular Dysfunction ; Pericardial Effusion ; Heart Valve Diseases ; Immunoglobulins, Intravenous/therapeutic use ; Echocardiography ; Stroke Volume ; Heart Defects, Congenital ; Steroids/therapeutic use ; Humans ; Male ; Female ; Child, Preschool ; Child
    Chemical Substances Immunoglobulins, Intravenous ; Steroids
    Language English
    Publishing date 2023-03-20
    Publishing country India
    Document type Review ; Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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  7. Article: Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection.

    Roca-Fernandez, Adriana / Wamil, Malgorzata / Telford, Alison / Carapella, Valentina / Borlotti, Alessandra / Monteiro, David / Thomaides-Brears, Helena / Kelly, Matt / Dennis, Andrea / Banerjee, Rajarshi / Robson, Matthew / Brady, Michael / Lip, Gregory Y H / Bull, Sacha / Heightman, Melissa / Ntusi, Ntobeko / Banerjee, Amitava

    Open heart

    2023  Volume 10, Issue 1

    Abstract: ... at follow-up. Of individuals with Long COVID, 102/534 (19%) had CMR abnormalities at baseline; 71/102 had ... COVID underwent CMR (T1/T2 mapping, cardiac mass, volumes, function and strain) and multiorgan MRI at 6 ... right ventricular dysfunction/dilatation and/or abnormal T1mapping), occurred in one in five individuals with Long COVID at 6 ...

    Abstract Background: Long COVID is associated with multiple symptoms and impairment in multiple organs. Cross-sectional studies have reported cardiac impairment to varying degrees by varying methodologies. Using cardiac MR (CMR), we investigated a 12-month trajectory of abnormalities in Long COVID.
    Objectives: To investigate cardiac abnormalities 1-year post-SARS-CoV-2 infection.
    Methods: 534 individuals with Long COVID underwent CMR (T1/T2 mapping, cardiac mass, volumes, function and strain) and multiorgan MRI at 6 months (IQR 4.3-7.3) since first post-COVID-19 symptoms. 330 were rescanned at 12.6 (IQR 11.4-14.2) months if abnormal baseline findings were reported. Symptoms, questionnaires and blood samples were collected at both time points. CMR abnormalities were defined as ≥1 of low left or right ventricular ejection fraction (LVEF), high left or right ventricular end diastolic volume, low 3D left ventricular global longitudinal strain (GLS), or elevated native T1 in ≥3 cardiac segments. Significant change over time was reported by comparison with 92 healthy controls.
    Results: Technical success of multiorgan and CMR assessment in non-acute settings was 99.1% and 99.6% at baseline, and 98.3% and 98.8% at follow-up. Of individuals with Long COVID, 102/534 (19%) had CMR abnormalities at baseline; 71/102 had complete paired data at 12 months. Of those, 58% presented with ongoing CMR abnormalities at 12 months. High sensitivity cardiac troponin I and B-type natriuretic peptide were not predictive of CMR findings, symptoms or clinical outcomes. At baseline, low LVEF was associated with persistent CMR abnormality, abnormal GLS associated with low quality of life and abnormal T1 in at least three segments was associated with better clinical outcomes at 12 months.
    Conclusion: CMR abnormalities (left entricular or right ventricular dysfunction/dilatation and/or abnormal T1mapping), occurred in one in five individuals with Long COVID at 6 months, persisting in over half of those at 12 months. Cardiac-related blood biomarkers could not identify CMR abnormalities in Long COVID.
    Trial registration number: NCT04369807.
    MeSH term(s) Humans ; Stroke Volume ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Cross-Sectional Studies ; Quality of Life ; Predictive Value of Tests ; SARS-CoV-2 ; Ventricular Function, Right
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2022-002241
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  8. Article ; Online: The Outcomes of Patients Incidentally Confirmed with Covid-19 After Cardiac Surgery.

    Uysal, Ayhan / Erturk, Esra / Abacilar, Ahmet Feyzi / Duman, Umit / Dogan, Omer Faruk

    The heart surgery forum

    2021  Volume 24, Issue 6, Page(s) E940–E946

    Abstract: ... in patients who were incidentally diagnosed with Covid-19 in the postoperative period.: Patients and methods ... Immunologic disorders resulting from ECC, physiologic distress, and anesthesia may activate Covid-19 during ... related to Covid-19 may develop in asymptomatic cardiac surgery patients with negative RT-PCR test results ...

    Abstract Background: The aim of this study was to investigate the clinical outcomes of cardiac surgery in patients who were incidentally diagnosed with Covid-19 in the postoperative period.
    Patients and methods: We performed 826 open cardiac surgeries in five tertiary centers. Most of the surgeries were elective coronary artery bypass grafting (CABG) (93.8%). A preoperative RT-PCR test and transcutaneous oxygen saturation were routinely investigated prior to surgery. We also investigated whether the patients already received Covid-19 treatment or had any contact with a Covid-19 patient in the last two weeks. We analyzed high sensitive C-reactive protein (hs-CRP), d-dimer, and fibrinogen, which plays a main role in the activation of procoagulant state after surgeries.
    Results: Acute lung injury related to Covid-19 activation was observed in 48 out of 826 patients (5.8%). The median age of 48 patients was 63.9±12.4 years. Euro-Score and body mass index (BMI) were 6.1±1.1 and 29.2±4.1kg/m², respectively. RT-PCR test results were positive in 29 patients (60.4%). We performed thoracic computed tomography (CT) in all patients with or without positive RT-PCR test results. Thoracic CT images showed that there was a different degree of ARDS (mild, moderate, and serious). The median time of extracorporeal circulation (ECC) was 93.2±14.6 min. in on-pump surgery (IQR, 68-155 min.). Common symptoms included dyspnea (N = 22; 45.8%) and fever (N = 12; 25%). Eleven patients needed readmission to ICU. Compared with non-admitted to ICU patients, ICU patients were higher comorbidities and severe laboratory abnormalities (eg, high blood d-dimer and fibrinogen). We also detected significantly low oxygen saturation, hypercapnia, and severe acidosis in readmitted patients. Radiologic investigations showed that there were severe ARDS with bilateral pneumonic infiltration resistant to medical treatment in 6 out of 11 patients who died (54.5%).
    Conclusion: Diffuse pneumonic infiltration related to Covid-19 may develop in asymptomatic cardiac surgery patients with negative RT-PCR test results. Immunologic disorders resulting from ECC, physiologic distress, and anesthesia may activate Covid-19 during the incubation period. We need randomized clinical trials to explain Covid-19 activation in the latent period of the virus, and clinical outcomes in cardiac surgery.
    MeSH term(s) Acute Lung Injury/diagnosis ; Acute Lung Injury/diagnostic imaging ; Acute Lung Injury/virology ; Aged ; COVID-19/diagnosis ; COVID-19/diagnostic imaging ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Cardiac Surgical Procedures ; Critical Care ; Female ; Humans ; Incidental Findings ; Male ; Middle Aged ; Oxygen Saturation ; Patient Readmission ; Postoperative Period ; Retrospective Studies ; SARS-CoV-2 ; Stress, Physiological ; Tomography, X-Ray Computed ; Virus Activation
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2069188-9
    ISSN 1522-6662 ; 1098-3511
    ISSN (online) 1522-6662
    ISSN 1098-3511
    DOI 10.1532/hsf.4259
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  9. Article ; Online: Cardiac Biomarker Abnormalities Are Closely Related to Prognosis in Patients with COVID-19.

    Tuo, Hu / Li, Wenjing / Tang, Lizhen / He, Bing / Yao, Baozhen / Mao, Ping / Tang, Qizhu

    International heart journal

    2020  Volume 62, Issue 1, Page(s) 148–152

    Abstract: ... the relationship of cardiac biomarkers and outcomes in severe cases of corona virus disease 2019 (COVID-19). One ... biomarkers have the potential for early warning and prognostic evaluation in patients with COVID-19. It is ... recommended that cardiac biomarker monitoring in patients with COVID-19 should be initiated at least ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is erupting and spreading globally. Cardiovascular complications secondary to the infection have caught notice. This study aims to delineate the relationship of cardiac biomarkers and outcomes in severe cases of corona virus disease 2019 (COVID-19). One hundred forty-eight critically ill adult patients with COVID-19 were enrolled. From these patients, the demographic data, symptoms, cardiac biomarkers, treatments, and clinical outcomes were collected. Data were compared between survivors and non-survivors. Four patients in the non-survivor group were selected, and their cardiac biomarkers were collected and analyzed. Among the 148 patients, the incidence of cardiovascular complications was 19 (12.8%). Five of them were survivors (5.2%), and 14 of them were non-survivors (26.9%). Compared with the survivors, the non-survivors had higher levels of high-sensitivity cardiac troponin I, creatine kinase isoenzyme-MB, myoglobin, and N-terminal pro-brain natriuretic peptide (P < 0.05). The occurrence of cardiovascular events began at 11-15 days after the onset of the disease and reached a peak at 14-20 days. COVID-19 not only is a respiratory disease but also causes damage to the cardiovascular system. Cardiac biomarkers have the potential for early warning and prognostic evaluation in patients with COVID-19. It is recommended that cardiac biomarker monitoring in patients with COVID-19 should be initiated at least from the 11th day of the disease course.
    MeSH term(s) Adult ; Aged ; Atrial Natriuretic Factor/metabolism ; Biomarkers/metabolism ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Case-Control Studies ; China/epidemiology ; Creatine Kinase, MB Form/metabolism ; Critical Illness/mortality ; Critical Illness/nursing ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prognosis ; Protein Precursors/metabolism ; SARS-CoV-2/genetics ; Survival Rate ; Survivors/statistics & numerical data ; Troponin I/metabolism
    Chemical Substances Biomarkers ; N-terminal proatrial natriuretic peptide ; Protein Precursors ; Troponin I ; Atrial Natriuretic Factor (85637-73-6) ; Creatine Kinase, MB Form (EC 2.7.3.2)
    Language English
    Publishing date 2020-12-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2187806-7
    ISSN 1349-3299 ; 1349-2365
    ISSN (online) 1349-3299
    ISSN 1349-2365
    DOI 10.1536/ihj.20-180
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  10. Article ; Online: Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19.

    Xu, Huayan / Hou, Keke / Xu, Rong / Li, Zhenlin / Fu, Hang / Wen, Lingyi / Xie, Linjun / Liu, Hui / Selvanayagam, Joseph B / Zhang, Na / Yang, Zhigang / Yang, Ming / Guo, Yingkun

    Journal of the American Heart Association

    2020  Volume 9, Issue 18, Page(s) e016807

    Abstract: ... disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and ... from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19-87 ... management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury ...

    Abstract Background Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. Methods and Results We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19-87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker abnormities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Betacoronavirus/pathogenicity ; Biomarkers/blood ; C-Reactive Protein/metabolism ; COVID-19 ; China/epidemiology ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Female ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Heart Diseases/therapy ; Heart Diseases/virology ; Host-Pathogen Interactions ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Up-Regulation ; Young Adult
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016807
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