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Article ; Online: Impact of COVID-19 on Children and Pediatricians.

Kulkarni, Rajesh K / Kinikar, Aarti A / Chandanwale, Ajay

2020 Volume 57, Issue 5, Page(s) 480–481

MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Child Health/standards ; Child Health Services/organization & administration ; Child Health Services/standards ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Health Knowledge, Attitudes, Practice ; Health Services Needs and Demand ; Humans ; India/epidemiology ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Influenza, Human/epidemiology ; Influenza, Human/psychology ; Information Dissemination/methods ; Pandemics/prevention & control ; Pediatricians ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Quality Improvement ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-09
Publishing country	India
Document type	Letter
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article: Impact of COVID-19 on Children and Pediatricians

Kulkarni, Rajesh K. / Kinikar, Aarti A. / Chandanwale, Ajay

Indian pediatrics

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46980
Database	COVID19

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Article ; Online: Impact of COVID-19 on Children and Pediatricians

Kulkarni, Rajesh K / Kinikar, Aarti A / Chandanwale, Ajay

Indian Pediatrics

2020 Volume 57, Issue 5, Page(s) 480–481

Keywords	Pediatrics, Perinatology, and Child Health ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	402594-5
ISSN	0019-6061
ISSN	0019-6061
DOI	10.1007/s13312-020-1833-7
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coagulation profile in hospitalized children with COVID-19: pediatric age dependency and its impact on long COVID development.

Boyarchuk, Oksana / Perestiuk, Vita / Kosovska, Tetyana / Volianska, Liubov

Frontiers in immunology

2024 Volume 15, Page(s) 1363410

Abstract: ... in the coagulation profile were revealed in 94.5% of children with COVID-19, and these changes were age-dependent ... in acute COVID-19. Moreover, persistent endotheliopathy and heightened coagulability frequently occur ... This could enhance our understanding of thromboinflammation in COVID-19 and its potential contribution ...

Abstract	Introduction: Pulmonary endotheliopathy and microvascular immunothrombosis play a key role in acute COVID-19. Moreover, persistent endotheliopathy and heightened coagulability frequently occur in individuals recovering from COVID-19, suggesting the intriguing possibility of their role in the development of long COVID. The aim of our study was to investigate the coagulation profile in patients with COVID-19 based on age and their role in the development of long COVID. Methods: We conducted a prospective single-center cohort study from September 2022 to August 2023. The study involved 190 patients younger than 18 years who were hospitalized at the Ternopil City Children's Hospital, Ukraine due to COVID-19. Patients underwent determination of coagulation profile in addition to the general clinical examination. After discharge from the hospital, patients were monitored for the presence of long COVID symptoms. Among the 157 participants who consented for follow-up, 62 patients (39.5%) had long COVID symptoms according to the WHO definition, while the rest (95 patients) did not have symptoms of long COVID (fully recovered). Results: The study revealed the normal count of platelets in the majority of patients (86.8%), whereas abnormalities in the coagulation profile were revealed in 94.5% of children with COVID-19, and these changes were age-dependent. The patients were mostly presented with increased activated partial thromboplastin time (69.1%), prothrombin time (PT) (39.8%) and D-dimer (45.0%). There was no significant difference between the median of platelet levels and coagulation profile indicators between the groups with long COVID and recovered. Among children who developed persistent long COVID symptoms there was a statistically higher percentage of abnormal PT values (53% versus 36.1%, p=0.0432), with no significant differences in other coagulation profile indicators. Abnormal PT along with female gender, comorbidities, especially allergic pathology, nutritional disorder, including obesity, were determined as potential risk factors of the long COVID development (Odds ratio - 2.0611; 95% 1.0179-4.1737, p=0.0445). Conclusions: The study highlights the need for more extensive research into the coagulation profiles of pediatric populations, considering age-specific factors. This could enhance our understanding of thromboinflammation in COVID-19 and its potential contribution to the development of persistent symptoms.
MeSH term(s)	Humans ; Female ; Child ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Child, Hospitalized ; Cohort Studies ; Inflammation/complications ; Prospective Studies ; Thrombosis/epidemiology ; Thrombosis/complications ; Blood Coagulation Disorders/etiology
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1363410
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Establishment of a pediatric COVID-19 biorepository: unique considerations and opportunities for studying the impact of the COVID-19 pandemic on children.

BMC medical research methodology

2020 Volume 20, Issue 1, Page(s) 228

Abstract: ... pediatric and neonatal COVID-19-related questions.: Methods: A COVID-19 biospecimen collection study was ... transmission by children, differences between pediatric and adult viral susceptibility and immune responses ... between children and adults, help determine the accuracy of current pediatric viral testing techniques ...

Abstract	Background: COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clinically apparent, collecting high-quality biospecimens from infants, children, and adolescents in a standardized manner during the COVID-19 pandemic is essential to establish a biologic understanding of the disease in the pediatric population. This biorepository enables pediatric centers world-wide to collect samples uniformly to drive forward our understanding of COVID-19 by addressing specific pediatric and neonatal COVID-19-related questions. Methods: A COVID-19 biospecimen collection study was implemented with strategic enrollment guidelines to include patients seen in urgent care clinics and hospital settings, neonates born to SARS-CoV-2 infected mothers, and asymptomatic children. The methodology described here, details the importance of establishing collaborations between the clinical and research teams to harmonize protocols for patient recruitment and sample collection, processing and storage. It also details modifications required for biobanking during a surge of the COVID-19 pandemic. Results: Considerations and challenges facing enrollment of neonatal and pediatric cohorts are described. A roadmap is laid out for successful collection, processing, storage and database management of multiple pediatric samples such as blood, nasopharyngeal and oropharyngeal swabs, sputum, saliva, tracheal aspirates, stool, and urine. Using this methodology, we enrolled 327 participants, who provided a total of 972 biospecimens. Conclusions: Pediatric biospecimens will be key in answering questions relating to viral transmission by children, differences between pediatric and adult viral susceptibility and immune responses, the impact of maternal SARS-CoV-2 infection on fetal development, and factors driving the Multisystem Inflammatory Syndrome in Children. The specimens in this biorepository will allow necessary comparative studies between children and adults, help determine the accuracy of current pediatric viral testing techniques, in addition to, understanding neonatal exposure to SARS-CoV-2 infection and disease abnormalities. The successful establishment of a pediatric biorepository is critical to provide insight into disease pathogenesis, and subsequently, develop future treatment and vaccination strategies.
MeSH term(s)	Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/transmission ; Female ; Fetal Development ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Specimen Handling/methods
Keywords	covid19
Language	English
Publishing date	2020-09-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1471-2288
ISSN (online)	1471-2288
DOI	10.1186/s12874-020-01110-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Establishment of a Pediatric COVID-19 Biorepository: Unique Considerations and Opportunities for Studying the Impact of the COVID-19 Pandemic on Children.

Research square

2020

Abstract: ... ...

Abstract	Background
Keywords	covid19
Language	English
Publishing date	2020-08-10
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-42030/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact and Perspectives of Pediatric Dental Care during the COVID-19 Pandemic Regarding Unvaccinated Children: A Cross-Sectional Survey.

Schulz-Weidner, Nelly / Schlenz, Maximiliane Amelie / Krämer, Norbert / Boukhobza, Sarra / Bekes, Katrin

International journal of environmental research and public health

2021 Volume 18, Issue 22

Abstract: ... In contrast to adults, many children are without any symptoms of disease if infected with COVID-19 and are not ... in pediatric patients was reported due to the fact of COVID-19. Furthermore, measures, such as oral hygiene and ... in Germany towards the impact of COVID-19 on daily patient care during the lockdowns caused by the pandemic ...

Abstract	The pandemic caused by the COVID-19 virus has led to enormous challenges in pediatric dental care. In contrast to adults, many children are without any symptoms of disease if infected with COVID-19 and are not vaccinated. The aim of this study was to conduct an inquiry into the perspective of pediatric dentists in Germany towards the impact of COVID-19 on daily patient care during the lockdowns caused by the pandemic. All members of the Germany Society of Pediatric Dentistry were invited to participate in an online survey. The questionnaire focused on five topics: safety measures, well-being/knowledge, patient care, prospects, and demographic data. A total of 549 pediatric dentists participated (58.11% females, 8.2% males, 0.18% inter/diverse, and 33.51% no answer). In total, 75.2% of the dental clinics were open during the first lockdown (LD1) and 78.1% during the second lockdown (LD2). In LD1, only 22.2% were operating at full capacity, while 40.1% were open with restrictions, and 11.8% only offered emergency treatment. In LD2, 71.2% of practices were operating again and resumed offering all treatment methods. A significant decrease in pediatric patients was reported due to the fact of COVID-19. Furthermore, measures, such as oral hygiene and recall appointments, were reduced. Measures that were performed after the lockdown were mainly aerosol-generating procedures and extractions as well as general anesthesia or sedation. The increased willingness to treat in the second lockdown has shown that pediatric dentists have adapted to the pandemic conditions, which seems to be of great importance, especially in view of the problem of unvaccinated children.
MeSH term(s)	Adult ; COVID-19 ; Child ; Communicable Disease Control ; Cross-Sectional Studies ; Dental Care ; Dentists ; Female ; Humans ; Male ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182212117
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of the impact of COVID-19 pandemic confinement on demand for pediatric emergency care and the characteristics of children attended.

Velasco Zúñiga, Roberto

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2021 Volume 33, Issue 1, Page(s) 78

Title translation	Análisis del impacto del confinamiento en la demanda asistencial y características de los pacientes atendidos en urgencias pediátricas.
MeSH term(s)	Accidents, Home/trends ; Adolescent ; COVID-19/epidemiology ; COVID-19/prevention & control ; Child ; Child, Preschool ; Emergency Service, Hospital/trends ; Emergency Treatment ; Facilities and Services Utilization/trends ; Female ; Health Services Accessibility/trends ; Health Services Needs and Demand/trends ; Humans ; Infant ; Male ; Pandemics ; Patient Acceptance of Health Care/statistics & numerical data ; Physical Distancing ; Retrospective Studies ; Spain/epidemiology ; Wounds and Injuries/epidemiology ; Wounds and Injuries/etiology
Language	English
Publishing date	2021-01-25
Publishing country	Spain
Document type	Letter
ZDB-ID	2127173-2
ISSN	2386-5857 ; 1137-6821
ISSN (online)	2386-5857
ISSN	1137-6821
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis.

Kujawski, Stephanie A / Yao, Lixia / Wang, H Echo / Carias, Cristina / Chen, Ya-Ting

Vaccine

2022 Volume 40, Issue 5, Page(s) 706–713

Abstract: ... child visit attendance and vaccination administration for children and adolescents during the COVID-19 ... and morbidity. We assessed the impact of the COVID-19 pandemic on pediatric and adolescent vaccination ... Background: The COVID-19 pandemic has disrupted healthcare, including immunization practice and ...

Abstract	Background: The COVID-19 pandemic has disrupted healthcare, including immunization practice and well child visit attendance. Maintaining vaccination coverage is important to prevent disease outbreaks and morbidity. We assessed the impact of the COVID-19 pandemic on pediatric and adolescent vaccination administration and well child visit attendance in the United States. Methods: This cross-sectional study used IBM MarketScan Commercial Database (IMC) with Early View (healthcare claims database) and TriNetX Dataworks Global Network (electronic medical records database) from January 2018-March 2021. Individuals ≤ 18 years of age who were enrolled during the analysis month of interest (IMC with Early View) or had ≥ 1 health encounter at a participating institution (TriNetX Dataworks) were included. We calculated the monthly percent difference between well child visit attendance and vaccine administration rates for 10 recommended pediatric/adolescent vaccines in 2020 and 2021 compared with 2018-2019. Data were stratified by the age groups 0-2 years, 4-6 years, and 9-16 years. Results: In IMC with Early View, the average monthly enrollment for children 0-18 years of age was 5.2 million. In TriNetX Dataworks, 12.2 million eligible individuals were included. Well child visits and vaccinations reached the lowest point in April 2020 compared with 2018-2019. Well child visit attendance and vaccine administration rates were inversely related to age, with initial reductions highest for adolescents and lowest for ages 0-2 years. Rates rebounded in June and September 2020 and stabilized to pre-pandemic levels in Fall 2020. Rates dropped below baseline in early 2021 for groups 0-2 years and 4-6 years. Conclusions: We found substantial disruptions in well child visit attendance and vaccination administration for children and adolescents during the COVID-19 pandemic in 2020 and early 2021. Continued efforts are needed to monitor recovery and catch up to avoid outbreaks and morbidity associated with vaccine-preventable diseases.
MeSH term(s)	Adolescent ; COVID-19 ; Child ; Child, Preschool ; Cross-Sectional Studies ; Humans ; Infant ; Infant, Newborn ; Pandemics ; SARS-CoV-2 ; United States/epidemiology ; Vaccination
Language	English
Publishing date	2022-01-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.12.064
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Article ; Online: Impact on rehabilitation programs during COVID-19 containment for children with pediatric and perinatal stroke.

Bertamino, Marta / Cornaglia, Sara / Zanetti, Alice / Di Rocco, Alessia / Ronchetti, Anna / Signa, Sara / Severino, Mariasavina / Moretti, Paolo

European journal of physical and rehabilitation medicine

2020 Volume 56, Issue 5, Page(s) 692–694

MeSH term(s)	Adolescent ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/diagnosis ; Coronavirus Infections/rehabilitation ; Female ; Humans ; Infant, Newborn ; Italy ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Physical and Rehabilitation Medicine/organization & administration ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/rehabilitation ; Pregnancy ; Pregnancy Complications, Infectious/rehabilitation ; Prognosis ; Risk Assessment ; Stroke/diagnosis ; Stroke Rehabilitation/methods ; Treatment Outcome
Keywords	covid19
Language	English
Publishing date	2020-06-09
Publishing country	Italy
Document type	Letter
ZDB-ID	2426908-6
ISSN	1973-9095 ; 1973-9087
ISSN (online)	1973-9095
ISSN	1973-9087
DOI	10.23736/S1973-9087.20.06407-2
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