Article: Respiratory Failure in an Extremely Premature Neonate with COVID-19.
2021 Volume 8, Issue 6
Abstract: ... week-gestation extremely premature infant born to a mother with COVID-19 infection. The infant ... Instituting appropriate COVID-19 protocols to prevent the spread of the disease in the neonatal ... Coronavirus disease 2019 (COVID-19), a condition associated with SARS-CoV-2, typically results ...
| Abstract | Coronavirus disease 2019 (COVID-19), a condition associated with SARS-CoV-2, typically results in mild infection in infants and children. However, children with risk factors such as chronic lung disease and immunosuppression have higher risk of severe illness from COVID-19. We report a case of a 27-week-gestation extremely premature infant born to a mother with COVID-19 infection. The infant, initially treated for surfactant deficiency, developed worsening hypoxic respiratory failure on the fifth day of life requiring escalating ventilatory support, an elevated level of C-reactive protein, thrombocytopenia, and an elevated level of d-dimer. The infant was positive for SARS-CoV-2 by RT-PCR from Day 1 to Day 42 of his life. The infant responded to a seven-day course of dexamethasone with a gradually decreasing oxygen requirement and could be extubated to non-invasive ventilation by the end of the fifth week after birth. The infant is currently on home oxygen by nasal cannula. Prolonged shedding of the virus may be a unique feature of the disease in premature infants. Extreme prematurity, immature lungs, and an immunocompromised status may predispose these infants to severe respiratory failure and a prolonged clinical course. Instituting appropriate COVID-19 protocols to prevent the spread of the disease in the neonatal intensive care unit (NICU) is of utmost importance. Infection with SARS-CoV-2 may have implications in the management of extremely premature infants in the NICU. |
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| Language | English |
| Publishing date | 2021-06-04 |
| Publishing country | Switzerland |
| Document type | Case Reports |
| ZDB-ID | 2732685-8 |
| ISSN | 2227-9067 |
| ISSN | 2227-9067 |
| DOI | 10.3390/children8060477 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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