LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article: Underestimation of COVID-19 mortality during the pandemic.

    Kung, Stacey / Doppen, Marjan / Black, Melissa / Braithwaite, Irene / Kearns, Ciléin / Weatherall, Mark / Beasley, Richard / Kearns, Nethmi

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Background: There has been considerable international variation in mortality during the COVID-19 ... as due to COVID-19 and the excess all-cause mortality reported in countries worldwide during the COVID-19 ... the increase in COVID-19 reported mortality. During the latter period of observation, a few countries reported ...

    Abstract Background: There has been considerable international variation in mortality during the COVID-19 pandemic. The objective of this study was to investigate the differences between mortality registered as due to COVID-19 and the excess all-cause mortality reported in countries worldwide during the COVID-19 pandemic.
    Methods: Ecological analysis of 22 countries compared 5-year historical all-cause mortality, reported all-cause mortality and expected all-cause mortality (calculated as historical mortality plus the reported deaths attributed to COVID-19). Data available from the first week of January 2020 to that most recently available were analysed.
    Results: Compared to the preceding 5 years, there was an excess of 716 616 deaths, of which 64.3% were attributed to COVID-19. The proportion of deaths registered as COVID-19-related/excess deaths varied markedly between countries, ranging between 30% and 197% in those countries that had an excess of deaths during the period of observation. In most countries where a definite peak in COVID-19-related deaths occurred, the increase in reported all-cause mortality preceded the increase in COVID-19 reported mortality. During the latter period of observation, a few countries reported fewer all-cause deaths than the historical figures.
    Conclusion: The increases in all-cause mortality preceded the increase in COVID-19 mortality in most countries that had definite spikes in COVID-19 mortality. The number of deaths attributed to COVID-19 was underestimated by at least 35%. Together these findings suggest that calculation of excess all-cause mortality is a better predictor of COVID-19 mortality than the reported rates, in those countries experiencing definite increases in mortality.
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00766-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Underestimation of COVID-19 mortality during the pandemic

    Stacey Kung / Marjan Doppen / Melissa Black / Irene Braithwaite / Ciléin Kearns / Mark Weatherall / Richard Beasley / Nethmi Kearns

    ERJ Open Research, Vol 7, Iss

    2021  Volume 1

    Abstract: Background There has been considerable international variation in mortality during the COVID-19 ... as due to COVID-19 and the excess all-cause mortality reported in countries worldwide during the COVID-19 ... in COVID-19 reported mortality. During the latter period of observation, a few countries reported fewer ...

    Abstract Background There has been considerable international variation in mortality during the COVID-19 pandemic. The objective of this study was to investigate the differences between mortality registered as due to COVID-19 and the excess all-cause mortality reported in countries worldwide during the COVID-19 pandemic. Methods Ecological analysis of 22 countries compared 5-year historical all-cause mortality, reported all-cause mortality and expected all-cause mortality (calculated as historical mortality plus the reported deaths attributed to COVID-19). Data available from the first week of January 2020 to that most recently available were analysed. Results Compared to the preceding 5 years, there was an excess of 716 616 deaths, of which 64.3% were attributed to COVID-19. The proportion of deaths registered as COVID-19-related/excess deaths varied markedly between countries, ranging between 30% and 197% in those countries that had an excess of deaths during the period of observation. In most countries where a definite peak in COVID-19-related deaths occurred, the increase in reported all-cause mortality preceded the increase in COVID-19 reported mortality. During the latter period of observation, a few countries reported fewer all-cause deaths than the historical figures. Conclusion The increases in all-cause mortality preceded the increase in COVID-19 mortality in most countries that had definite spikes in COVID-19 mortality. The number of deaths attributed to COVID-19 was underestimated by at least 35%. Together these findings suggest that calculation of excess all-cause mortality is a better predictor of COVID-19 mortality than the reported rates, in those countries experiencing definite increases in mortality.
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  3. Article ; Online: Underestimation in Reporting Excess COVID-19 Death Data in Poland during the First Three Pandemic Waves.

    Walkowiak, Marcin Piotr / Walkowiak, Dariusz

    International journal of environmental research and public health

    2022  Volume 19, Issue 6

    Abstract: ... on the basis of our model explain 55% of excess mortality, for the remaining age groups, combined COVID-19 ... deaths explain 95% of excess mortality. Based on the share of excess mortality attributable to COVID-19 ... pandemic wave, our data on excess mortality will match very well the somewhat belatedly officially reported ...

    Abstract The issue whether official Polish COVID-19 death statistics correctly reflect the actual number of deaths is a contentious issue in public discourse and an important policy-wise question in Poland although it has not been the subject of thorough research so far. There had been clearly elevated excess mortality-5100 (death rate of 2.3 per 10,000) during the first wave, 77,500 (21.0 per 10,000) during the second one, and 48,900 (13.5 per 10,000) in the third. This study finds that during the second and the third pandemic wave, our data on excess mortality will match very well the somewhat belatedly officially reported COVID-19 deaths if we assume that only 60% of cases were officially detected. Based on principal component analysis of death timing, except for the age bracket below 40, where COVID-19 deaths calculated on the basis of our model explain 55% of excess mortality, for the remaining age groups, combined COVID-19 deaths explain 95% of excess mortality. Based on the share of excess mortality attributable to COVID-19 during the second wave, this infection in Poland caused the death of 73,300 people and not of 37,600 as officially reported. The third wave caused 46,200 deaths instead of the reported 34,700. The first wave was, indeed, as officially reported, very mild, and the number of excess deaths was too low to be used to calculate COVID-19 deaths directly. However, assuming that the detection rate remained comparable to the average in subsequent waves, we can set the number of deaths at 3500 instead of the reported 2100.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics ; Poland/epidemiology ; Policy ; Research Design
    Language English
    Publishing date 2022-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19063692
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Underestimation in Reporting Excess COVID-19 Death Data in Poland during the First Three Pandemic Waves

    Marcin Piotr Walkowiak / Dariusz Walkowiak

    International Journal of Environmental Research and Public Health, Vol 19, Iss 3692, p

    2022  Volume 3692

    Abstract: ... on the basis of our model explain 55% of excess mortality, for the remaining age groups, combined COVID-19 ... deaths explain 95% of excess mortality. Based on the share of excess mortality attributable to COVID-19 ... pandemic wave, our data on excess mortality will match very well the somewhat belatedly officially reported ...

    Abstract The issue whether official Polish COVID-19 death statistics correctly reflect the actual number of deaths is a contentious issue in public discourse and an important policy-wise question in Poland although it has not been the subject of thorough research so far. There had been clearly elevated excess mortality—5100 (death rate of 2.3 per 10,000) during the first wave, 77,500 (21.0 per 10,000) during the second one, and 48,900 (13.5 per 10,000) in the third. This study finds that during the second and the third pandemic wave, our data on excess mortality will match very well the somewhat belatedly officially reported COVID-19 deaths if we assume that only 60% of cases were officially detected. Based on principal component analysis of death timing, except for the age bracket below 40, where COVID-19 deaths calculated on the basis of our model explain 55% of excess mortality, for the remaining age groups, combined COVID-19 deaths explain 95% of excess mortality. Based on the share of excess mortality attributable to COVID-19 during the second wave, this infection in Poland caused the death of 73,300 people and not of 37,600 as officially reported. The third wave caused 46,200 deaths instead of the reported 34,700. The first wave was, indeed, as officially reported, very mild, and the number of excess deaths was too low to be used to calculate COVID-19 deaths directly. However, assuming that the detection rate remained comparable to the average in subsequent waves, we can set the number of deaths at 3500 instead of the reported 2100.
    Keywords excess mortality ; excess deaths ; COVID-19 ; Poland ; public health ; Medicine ; R
    Subject code 310
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Is the role of forensic medicine in the covid-19 pandemic underestimated?

    Bogdanović, Milenko / Atanasijević, Tatjana / Popović, Vesna / Mihailović, Zoran / Radnić, Bojana / Durmić, Tijana

    Forensic science, medicine, and pathology

    2020  Volume 17, Issue 1, Page(s) 136–138

    Abstract: ... this new illness and its clinical management. Therefore, autopsies during the COVID-19 pandemic should not ... contribution to the accuracy of mortality statistics, understanding pathological mechanisms of COVID-19 ... Forensic pathologists should ask and answer various questions through autopsy cases during the COVID-19 period ...

    Abstract We believe that forensic medicine should play a significant role in the COVID-19 pandemic. Forensic pathologists should ask and answer various questions through autopsy cases during the COVID-19 period, thus providing a significant contribution to science. Some of the potential roles of forensic medicine in this issue include: determining the exact cause of death among the deceased who were SARS-CoV-2 positive, contribution to the accuracy of mortality statistics, understanding pathological mechanisms of COVID-19, tracking the presence of the virus over time, survival of the virus after death as well as dealing with medicolegal issues. A detailed multidisciplinary analysis of autopsy samples would undoubtedly help understand this new illness and its clinical management. Therefore, autopsies during the COVID-19 pandemic should not be an exception, but certainly a rule.
    MeSH term(s) Autopsy ; COVID-19/pathology ; COVID-19/prevention & control ; COVID-19/transmission ; Cause of Death ; Data Collection ; Forensic Medicine ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Pandemics ; Professional Role ; SARS-CoV-2 ; Virus Latency
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-020-00308-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Critical care nutrition and COVID-19: a cause of malnutrition not to be underestimated.

    Eden, Timothy / McAuliffe, Shane

    BMJ nutrition, prevention & health

    2021  Volume 4, Issue 1, Page(s) 342–347

    Abstract: ... on morbidity and mortality. During the current COVID-19 pandemic, the evolving literature has been able ... pre-existing medical conditions but presenting with severe COVID-19 during the first wave ... Nutritional status and provision precritical and pericritical phase of COVID-19 illness is gaining traction ...

    Abstract Malnutrition in critical care is highly prevalent and well documented to have adverse implications on morbidity and mortality. During the current COVID-19 pandemic, the evolving literature has been able to identify high risk groups in whom unfavourable outcomes are more common, for example, obesity, premorbid status, male sex, members from the Black, Asian and Minority Ethnic (BAME) community and others. Nutritional status and provision precritical and pericritical phase of COVID-19 illness is gaining traction in the literature assessing how this can influence the clinical course. It is therefore of importance to understand and address the challenges present in critical care nutrition and to identify and mitigate factors contributing to malnutrition specific to this patient group. We report a case of significant disease burden and the associated cachexia and evidence of malnutrition in a young 36-year-old male with Somalian heritage with no pre-existing medical conditions but presenting with severe COVID-19 during the first wave of the pandemic (March 2020). We highlight some key nutritional challenges during the critical phase of illness signposting to some of the management instigated to counter this. These considerations are hoped to provide further insight to help continue to evolve nutritional management when treating patients with COVID-19.
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article
    ISSN 2516-5542
    ISSN (online) 2516-5542
    DOI 10.1136/bmjnph-2021-000271
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Is the role of forensic medicine in the covid-19 pandemic underestimated?

    Bogdanovic, Milenko / Atanasijevic, Tatjana / Popovic, Vesna / Mihailovic, Zoran / Radnic, Bojana / Durmic, Tijana

    Forensic sci. med. pathol. (Online)

    Abstract: ... this new illness and its clinical management. Therefore, autopsies during the COVID-19 pandemic should not ... contribution to the accuracy of mortality statistics, understanding pathological mechanisms of COVID-19 ... Forensic pathologists should ask and answer various questions through autopsy cases during the COVID-19 period ...

    Abstract We believe that forensic medicine should play a significant role in the COVID-19 pandemic. Forensic pathologists should ask and answer various questions through autopsy cases during the COVID-19 period, thus providing a significant contribution to science. Some of the potential roles of forensic medicine in this issue include: determining the exact cause of death among the deceased who were SARS-CoV-2 positive, contribution to the accuracy of mortality statistics, understanding pathological mechanisms of COVID-19, tracking the presence of the virus over time, survival of the virus after death as well as dealing with medicolegal issues. A detailed multidisciplinary analysis of autopsy samples would undoubtedly help understand this new illness and its clinical management. Therefore, autopsies during the COVID-19 pandemic should not be an exception, but certainly a rule.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #778073
    Database COVID19

    Kategorien

  8. Article ; Online: The National Early Warning Score (NEWS2) systematically underestimates the risk of in-hospital mortality in unplanned COVID-19 admissions to hospital.

    Richardson, Donald / Faisal, Muhammad / Fiori, Massimo / Beatson, Kevin / A Mohammed, Mohammed

    medRxiv

    Abstract: ... predictor of the mortality risk but substantially underestimates the absolute mortality risk in COVID-19 ... to predict mortality at four time points (in-hospital, 24hours, 48hours, and 72hours) in COVID-19 versus non ... about their performance in COVID-19 patients. We analysed the performance of National Early Warning Score (NEWS2) during ...

    Abstract Background: Although the National Early Warning Score (NEWS) and its latest version NEWS2 are recommended for monitoring for deterioration in patients admitted to hospital, little is known about their performance in COVID-19 patients. We analysed the performance of National Early Warning Score (NEWS2) during the first phase of the COVID-19 pandemic. Methods: Adult non-elective admissions discharged between 11-March-2020 to 13-June-2020 with an index NEWS2 electronically recorded within 24 hours of admission are used to predict mortality at four time points (in-hospital, 24hours, 48hours, and 72hours) in COVID-19 versus non-COVID-19 admissions. Results: Out of 6480 non-elective admissions, 620 (9.6%) had a diagnosis of COVID-19. They were older (73.3 vs 67.7yrs), more often male (54.7% vs 50.1%), had higher index NEWS (4 vs 2.5) and NEWS2 (4.6 vs 2.8) scores and higher in-hospital mortality (32.1% vs 5.8%). The c-statistics for predicting in-hospital mortality in COVID-19 admissions was significantly lower using NEWS (0.64 vs 0.74) or NEWS2 (0.64 vs 0.74), however these differences reduced at 72hours (NEWS: 0.75 vs 0.81; NEWS2: 0.71 vs 0.81), 48 hours (NEWS: 0.78 vs 0.81; NEWS2: 0.76 vs 0.82) and 24hours (NEWS: 0.84 vs 0.84; NEWS2: 0.86 vs 0.84). Increasing NEWS2 values reflected increased mortality, but for any given value the absolute risk was on average 24% higher (e.g.NEWS2=5: 36% vs 9%). Interpretation: NEWS2 is a valid predictor of the mortality risk but substantially underestimates the absolute mortality risk in COVID-19 patients. Clinical staff
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.07.13.20144907
    Database COVID19

    Kategorien

  9. Article ; Online: The National Early Warning Score (NEWS2) systematically underestimates the risk of in-hospital mortality in unplanned COVID-19 admissions to hospital.

    Richardson, D. / Faisal, M. / Fiori, M. / Beatson, K. / A Mohammed, M.

    Abstract: ... predictor of the mortality risk but substantially underestimates the absolute mortality risk in COVID-19 ... to predict mortality at four time points (in-hospital, 24hours, 48hours, and 72hours) in COVID-19 versus non ... about their performance in COVID-19 patients. We analysed the performance of National Early Warning Score (NEWS2) during ...

    Abstract Background: Although the National Early Warning Score (NEWS) and its latest version NEWS2 are recommended for monitoring for deterioration in patients admitted to hospital, little is known about their performance in COVID-19 patients. We analysed the performance of National Early Warning Score (NEWS2) during the first phase of the COVID-19 pandemic. Methods: Adult non-elective admissions discharged between 11-March-2020 to 13-June-2020 with an index NEWS2 electronically recorded within 24 hours of admission are used to predict mortality at four time points (in-hospital, 24hours, 48hours, and 72hours) in COVID-19 versus non-COVID-19 admissions. Results: Out of 6480 non-elective admissions, 620 (9.6%) had a diagnosis of COVID-19. They were older (73.3 vs 67.7yrs), more often male (54.7% vs 50.1%), had higher index NEWS (4 vs 2.5) and NEWS2 (4.6 vs 2.8) scores and higher in-hospital mortality (32.1% vs 5.8%). The c-statistics for predicting in-hospital mortality in COVID-19 admissions was significantly lower using NEWS (0.64 vs 0.74) or NEWS2 (0.64 vs 0.74), however these differences reduced at 72hours (NEWS: 0.75 vs 0.81; NEWS2: 0.71 vs 0.81), 48 hours (NEWS: 0.78 vs 0.81; NEWS2: 0.76 vs 0.82) and 24hours (NEWS: 0.84 vs 0.84; NEWS2: 0.86 vs 0.84). Increasing NEWS2 values reflected increased mortality, but for any given value the absolute risk was on average 24% higher (e.g.NEWS2=5: 36% vs 9%). Interpretation: NEWS2 is a valid predictor of the mortality risk but substantially underestimates the absolute mortality risk in COVID-19 patients. Clinical staff
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.07.13.20144907
    Database COVID19

    Kategorien

To top