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  1. Article ; Online: Comprehensive mapping of immune perturbations associated with severe COVID-19.

    Kuri-Cervantes, Leticia / Pampena, M Betina / Meng, Wenzhao / Rosenfeld, Aaron M / Ittner, Caroline A G / Weisman, Ariel R / Agyekum, Roseline S / Mathew, Divij / Baxter, Amy E / Vella, Laura A / Kuthuru, Oliva / Apostolidis, Sokratis A / Bershaw, Luanne / Dougherty, Jeanette / Greenplate, Allison R / Pattekar, Ajinkya / Kim, Justin / Han, Nicholas / Gouma, Sigrid /
    Weirick, Madison E / Arevalo, Claudia P / Bolton, Marcus J / Goodwin, Eileen C / Anderson, Elizabeth M / Hensley, Scott E / Jones, Tiffanie K / Mangalmurti, Nilam S / Luning Prak, Eline T / Wherry, E John / Meyer, Nuala J / Betts, Michael R

    Science immunology

    2020  Volume 5, Issue 49

    Abstract: ... correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune ... severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found ... Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune ...

    Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
    MeSH term(s) Aged ; B-Lymphocyte Subsets/immunology ; Betacoronavirus/immunology ; COVID-19 ; Clonal Selection, Antigen-Mediated/immunology ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Cytokines/metabolism ; Female ; Humans ; Immunity, Innate/immunology ; Immunologic Memory/immunology ; Lymphocyte Activation/immunology ; Lymphocyte Count ; Male ; Middle Aged ; Neutrophils/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; T-Lymphocytes/immunology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abd7114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comprehensive mapping of immune perturbations associated with severe COVID-19

    Kuri-Cervantes, Leticia / Pampena, M. Betina / Meng, Wenzhao / Rosenfeld, Aaron M. / Ittner, Caroline A.G. / Weisman, Ariel R. / Agyekum, Roseline S. / Mathew, Divij / Baxter, Amy E. / Vella, Laura A. / Kuthuru, Oliva / Apostolidis, Sokratis A. / Bershaw, Luanne / Dougherty, Jeanette / Greenplate, Allison R. / Pattekar, Ajinkya / Kim, Justin / Han, Nicholas / Gouma, Sigrid /
    Weirick, Madison E. / Arevalo, Claudia P. / Bolton, Marcus J. / Goodwin, Eileen C. / Anderson, Elizabeth M. / Hensley, Scott E. / Jones, Tiffanie K. / Mangalmurti, Nilam S. / Luning Prak, Eline T. / Wherry, E. John / Meyer, Nuala J. / Betts, Michael R.

    Science Immunology

    2020  Volume 5, Issue 49, Page(s) eabd7114

    Abstract: ... correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune ... severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found ... Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune ...

    Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
    Keywords covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ISSN 2470-9468
    DOI 10.1126/sciimmunol.abd7114
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Comprehensive mapping of immune perturbations associated with severe COVID-19

    Kuri-Cervantes, Leticia / Pampena, M Betina / Meng, Wenzhao / Rosenfeld, Aaron M / Ittner, Caroline A G / Weisman, Ariel R / Agyekum, Roseline S / Mathew, Divij / Baxter, Amy E / Vella, Laura A / Kuthuru, Oliva / Apostolidis, Sokratis A / Bershaw, Luanne / Dougherty, Jeanette / Greenplate, Allison R / Pattekar, Ajinkya / Kim, Justin / Han, Nicholas / Gouma, Sigrid /
    Weirick, Madison E / Arevalo, Claudia P / Bolton, Marcus J / Goodwin, Eileen C / Anderson, Elizabeth M / Hensley, Scott E / Jones, Tiffanie K / Mangalmurti, Nilam S / Luning Prak, Eline T / Wherry, E John / Meyer, Nuala J / Betts, Michael R

    Sci. immunol

    Abstract: ... correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune ... severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found ... Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune ...

    Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646575
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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