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  1. Article ; Online: Whole-body diffusion-weighted imaging for staging malignant lymphoma in children.

    Kwee, Thomas C / Takahara, Taro / Vermoolen, Malou A / Bierings, Marc B / Mali, Willem P / Nievelstein, Rutger A J

    Pediatric radiology

    2010  Volume 40, Issue 10, Page(s) 1592–602; quiz 1720–1

    Abstract: ... whole-body diffusion-weighted imaging (DWI) in particular, may be a good radiation-free alternative ... body MRI techniques for staging malignant lymphoma with emphasis on whole-body DWI. Furthermore, future ... CT is currently the mainstay in staging malignant lymphoma in children, but the risk of second ...

    Abstract CT is currently the mainstay in staging malignant lymphoma in children, but the risk of second neoplasms due to ionizing radiation associated with CT is not negligible. Whole-body MRI techniques and whole-body diffusion-weighted imaging (DWI) in particular, may be a good radiation-free alternative to CT. DWI is characterized by high sensitivity for the detection of lesions and allows quantitative assessment of diffusion that may aid in the evaluation of malignant lymphomas. This article will review whole-body MRI techniques for staging malignant lymphoma with emphasis on whole-body DWI. Furthermore, future considerations and challenges in whole-body DWI will be discussed.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Infant ; Lymphoma/diagnosis ; Neoplasm Staging/methods ; Whole Body Imaging/methods
    Language English
    Publishing date 2010-07-30
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-010-1775-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 927: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Whole-body MR imaging in children: principles, technique, current applications, and future directions.

    Chavhan, Govind B / Babyn, Paul S

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2011  Volume 31, Issue 6, Page(s) 1757–1772

    Abstract: ... in a single examination. Whole-body MR imaging is particularly useful for examining children because it does ... to differentiate benign from malignant lymphadenopathy. However, whole-body MR imaging performed with integrated ... nononcologic imaging continues to expand. Its use in the staging of lymphoma and other malignancies has been ...

    Abstract In whole-body magnetic resonance (MR) imaging, the entire body from the vertex to the toes is imaged in one or more planes with one or multiple sequences to allow evaluation of multisystem diseases in a single examination. Whole-body MR imaging is particularly useful for examining children because it does not involve exposure to radiation and allows a complete work-up for disease staging within a single session of sedation or anesthesia. At whole-body MR imaging with a sliding table platform, a body coil may be used, but the resultant images have a low signal-to-noise ratio (SNR) and low resolution; use of a combination of phased-array coils results in images with an improved SNR and higher resolution. As whole-body MR imaging techniques undergo further refinement, the role of the modality in oncologic and nononcologic imaging continues to expand. Its use in the staging of lymphoma and other malignancies has been studied extensively. Whole-body MR imaging does not provide functional information and cannot yet be used to differentiate benign from malignant lymphadenopathy. However, whole-body MR imaging performed with integrated diffusion-weighted sequences may complement or replace positron emission tomography, which involves substantial radiation exposure. Other promising avenues for future research include whole-body MR imaging at 3 T and the combination of molecular imaging or positron emission tomography with whole-body MR imaging.
    MeSH term(s) Adolescent ; Child ; Contrast Media ; Forecasting ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/trends ; Neoplasms/diagnosis ; Whole Body Imaging/trends
    Chemical Substances Contrast Media
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.316115523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1751: Show issues Location:
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  3. Article ; Online: Ionising radiation-free whole-body MRI versus (18)F-fluorodeoxyglucose PET/CT scans for children and young adults with cancer: a prospective, non-randomised, single-centre study.

    Klenk, Christopher / Gawande, Rakhee / Uslu, Lebriz / Khurana, Aman / Qiu, Deqiang / Quon, Andrew / Donig, Jessica / Rosenberg, Jarrett / Luna-Fineman, Sandra / Moseley, Michael / Daldrup-Link, Heike E

    The Lancet. Oncology

    2014  Volume 15, Issue 3, Page(s) 275–285

    Abstract: ... with malignant lymphomas and sarcomas. Whole-body diffusion-weighted magnetic resonance images were generated ... ionising radiation-free staging method based on whole-body diffusion-weighted MRI and the iron supplement ferumoxytol ... for whole-body diffusion-weighted MRI. (18)F-FDG PET/CT detected 163 of 174 malignant lesions at 1325 ...

    Abstract Background: Imaging tests are essential for staging of children with cancer. However, CT and radiotracer-based imaging procedures are associated with substantial exposure to ionising radiation and risk of secondary cancer development later in life. Our aim was to create a highly effective, clinically feasible, ionising radiation-free staging method based on whole-body diffusion-weighted MRI and the iron supplement ferumoxytol, used off-label as a contrast agent.
    Methods: We compared whole-body diffusion-weighted MRI with standard clinical (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT scans in children and young adults with malignant lymphomas and sarcomas. Whole-body diffusion-weighted magnetic resonance images were generated by coregistration of colour-encoded ferumoxytol-enhanced whole-body diffusion-weighted MRI scans for tumour detection with ferumoxytol-enhanced T1-weighted MRI scans for anatomical orientation, similar to the concept of integrated (18)F-FDG PET/CT scans. Tumour staging results were compared using Cohen's κ statistics. Histopathology and follow-up imaging served as the standard of reference. Data was assessed in the per-protocol population. This study is registered with ClinicalTrials.gov, number NCT01542879.
    Findings: 22 of 23 recruited patients were analysed because one patient discontinued before completion of the whole-body scan. Mean exposure to ionising radiation was 12·5 mSv (SD 4·1) for (18)F-FDG PET/CT compared with zero for whole-body diffusion-weighted MRI. (18)F-FDG PET/CT detected 163 of 174 malignant lesions at 1325 anatomical regions and whole-body diffusion-weighted MRI detected 158. Comparing (18)F-FDG PET/CT to whole-body diffusion-weighted MRI, sensitivities were 93·7% (95% CI 89·0-96·8) versus 90·8% (85·5-94·7); specificities 97·7% (95% CI 96·7-98·5) versus 99·5% (98·9-99·8); and diagnostic accuracies 97·2% (93·6-99·4) versus 98·3% (97·4-99·2). Tumour staging results showed very good agreement between both imaging modalities with a κ of 0·93 (0·81-1·00). No adverse events after administration of ferumoxytol were recorded.
    Interpretation: Ferumoxytol-enhanced whole-body diffusion-weighted MRI could be an alternative to (18)F-FDG PET/CT for staging of children and young adults with cancer that is free of ionising radiation. This new imaging test might help to prevent long-term side-effects from radiographic staging procedures.
    Funding: Thrasher Research Fund and Clinical Health Research Institute at Stanford University.
    MeSH term(s) Adolescent ; Adult ; Child ; Diffusion Magnetic Resonance Imaging/methods ; Fluorodeoxyglucose F18 ; Humans ; Multimodal Imaging ; Neoplasms/diagnosis ; Positron-Emission Tomography/methods ; Prospective Studies ; Radiopharmaceuticals ; Tomography, X-Ray Computed/methods ; Whole Body Imaging/methods ; Young Adult
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(14)70021-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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