Article ; Online: Clinical and epidemiological data of COVID-19 from Regensburg, Germany: a retrospective analysis of 1084 consecutive cases.
2021 Volume 49, Issue 4, Page(s) 661–669
Abstract: ... duration of symptoms and COVID-19 risk factors until June 26, 2020.: Results: Of 1089 total cases, 1084 ... cohort of consecutive COVID-19 cases recorded between March 7, 2020 and May 24, 2020 as part ... clinical and epidemiologic data in an almost complete cohort of SARS-CoV-2 positive individuals ...
| Abstract | Background: COVID-19 is a syndrome caused by the recently emerged SARS-CoV-2. We collected clinical and epidemiologic data in an almost complete cohort of SARS-CoV-2 positive individuals from Regensburg, Germany, from March 2020 to May 2020. Methods: Analysis of a retrospectively documented cohort of consecutive COVID-19 cases recorded between March 7, 2020 and May 24, 2020 as part of an infection control investigation program, with prospective follow-up interviews gathering information on type and duration of symptoms and COVID-19 risk factors until June 26, 2020. Results: Of 1089 total cases, 1084 (99.5%) cases were included. The incidence during the time period was 315.4/100,000, lower than in the superordinate government district Oberpfalz (468.5/100,000) and the overall state of Bavaria (359.7/100,000). The case fatality ratio (CFR) was 2.1%. Among fatal cases, the mean age was 74.4 years and 87% presented with known risk factors, most commonly chronic heart disease, chronic lung disease, kidney disease, and diabetes mellitus. 897 cases (82.7%) showed at least one symptom, most frequently cough (45%) and fever (41%). Further, 18% of cases suffered from odour/taste disorder. 17% of total cases reported no symptoms. The median duration of general illness was 10 days. During follow-up, 8.9% of 419 interviewed cases reported at least one symptom lasting at least 6 weeks, and fatigue was the most frequent persistent symptom. Discussion: We report data on type and duration of symptoms, and clinical severity of nearly all (99.5%) patients with SARS-CoV-2 recorded from March 2020 to May 2020 in Regensburg. A broad range of symptoms and symptom duration was seen, some of them lasting several weeks in a considerable number of cases. The case-fatality ratio was 2.1%. Asymptomatic cases may be underrepresented due to the nature of the study. |
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| MeSH term(s) | Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/mortality ; Child ; Child, Preschool ; Cohort Studies ; Disease Outbreaks ; Female ; Germany/epidemiology ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Male ; Middle Aged ; Retrospective Studies ; Sex Distribution ; Time Factors ; Young Adult | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-03-05 | ||||||||||
| Publishing country | Germany | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 185104-4 | ||||||||||
| ISSN | 1439-0973 ; 0300-8126 ; 0173-2129 | ||||||||||
| ISSN (online) | 1439-0973 | ||||||||||
| ISSN | 0300-8126 ; 0173-2129 | ||||||||||
| DOI | 10.1007/s15010-021-01580-2 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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