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  1. Book ; Online: Advances in Parvovirus Research 2022

    Gallinella, Giorgio

    2023  

    Keywords Medicine ; Epidemiology & medical statistics ; parvovirus B19 ; synthetic genome ; genetic engineering ; replicon unit ; functional complementation ; B19V ; VP1u ; VP1uR ; receptor ; tropism ; primate erythroparvovirus ; simian erythroparvovirus ; rhesus erythroparvovirus ; pig-tailed erythroparvovirus ; Benzonase® ; acute infection ; persistent infection ; viral DNA load ; oncolytic virus immunotherapy ; protoparvovirus H-1PV ; virus host interactions ; virus cell entry ; galectin-1 ; laminin γ1 ; adeno-associated virus ; AAV ; classification ; genotype ; serotype ; intraspecies ; pairwise genetic distance ; recombination ; porcine parvovirus ; virus-like particles ; diagnostic ; I-ELISA ; parvovirus ; capsid ; AMDV ; PARV4 ; cryo-EM ; Amdoparvovirus ; Tetraparvovirus ; pathogen ; CPV-2 ; FPV ; illegal trade ; companion animals ; wildlife ; spillover ; porcine parvovirus 1 ; Africa ; epidemiology ; phylogeography ; phylogeny ; VP2 ; H1-PV ; infection ; oncolytic virus ; anticancer gene ; cancer gene therapy ; cancer ; Parvovirus B19 ; genetic diversity ; viral quasispecies ; Next Generation Sequencing ; Shannon Entropy ; cluster analysis ; skunk amdoparvovirus ; striped skunk ; next generation sequencing ; virus surveillance ; HIV infection ; hemolysis ; hereditary spherocytosis ; parvoviruses ; DNA damage response ; Minute Virus of Mice ; immunity ; evolution ; paleovirology ; endogenous viral elements ; bocavirus ; CnMV ; PBoV ; RBoV ; canine parvovirus type 2 ; molecular epidemiology ; Protoparvovirus carnivoran1 ; virus evolution ; Parvoviridae ; international workshop ; conference report
    Language English
    Size 1 electronic resource (288 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030645422
    ISBN 9783036594491 ; 3036594493
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Parvovirus B19 in Pregnancy.

    Boissiere, Jaye / Watkins, Virginia / Kuller, Jeffrey A / Dotters-Katz, Sarah K

    Obstetrical & gynecological survey

    2024  Volume 79, Issue 5, Page(s) 281–289

    Abstract: Importance: Although the risk of parvovirus B19 infection during pregnancy and subsequent risk ... by parvovirus B19 infection is needed.: Objective: This review describes the risks associated with parvovirus ... Medline, and OVID; pertinent articles were reviewed.: Results: Parvovirus B19 is a viral infection ...

    Abstract Importance: Although the risk of parvovirus B19 infection during pregnancy and subsequent risk of adverse fetal outcome are low, understanding management practices is essential for proper treatment of fetuses with nonimmune hydrops fetalis. In addition, continued investigation into delivery management, breastfeeding recommendations, and congenital abnormalities associated with pregnancies complicated by parvovirus B19 infection is needed.
    Objective: This review describes the risks associated with parvovirus B19 infection during pregnancy and the management strategies for fetuses with vertically transmitted infections.
    Evidence acquisition: Original articles were obtained from literature search in PubMed, Medline, and OVID; pertinent articles were reviewed.
    Results: Parvovirus B19 is a viral infection associated with negative pregnancy outcomes. Up to 50% of people of reproductive age are susceptible to the virus. The incidence of B19 in pregnancy is between 0.61% and 1.24%, and, overall, there is 30% risk of vertical transmission when infection is acquired during pregnancy. Although most pregnancies progress without negative outcomes, viral infection of the fetus may result in severe anemia, congestive heart failure, and hydrops fetalis. In addition, vertical transmission carries a 5% to 10% chance of fetal loss. In pregnancies affected by fetal B19 infection, Doppler examination of the middle cerebral artery peak systolic velocity should be initiated to surveil for fetal anemia. In the case of severe fetal anemia, standard fetal therapy involves an intrauterine transfusion of red blood cells with the goal of raising hematocrit levels to approximately 40% to 50% of total blood volume. One transfusion is usually sufficient, although continued surveillance may indicate the need for subsequent transfusions. There are fewer epidemiologic data concerning neonatal risks of congenital parvovirus, although case reports have shown that fetuses with severe anemia in utero may have persistent anemia, thrombocytopenia, and edema in the neonatal period.
    Conclusions and relevance: Parvovirus B19 is a common virus; seropositivity in the geriatric population reportedly reaches 85%. Within the pregnant population, up to 50% of patients have not previously been exposed to the virus and consequently lack protective immunity. Concern for parvovirus B19 infection in pregnancy largely surrounds the consequences of vertical transmission of the virus to the fetus. Should vertical transmission occur, the overall risk of fetal loss is between 5% and 10%. Thus, understanding the incidence, risks, and management strategies of pregnancies complicated by parvovirus B19 is essential to optimizing care and outcomes. Further, there is currently a gap in evidence regarding delivery management, breastfeeding recommendations, and the risks of congenital abnormalities in pregnancies complicated by parvovirus B19. Additional investigations into optimal delivery management, feeding plans, and recommended neonatal surveillance are needed in this cohort of patients.
    MeSH term(s) Humans ; Pregnancy ; Female ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/virology ; Pregnancy Complications, Infectious/therapy ; Parvovirus B19, Human ; Hydrops Fetalis/epidemiology ; Hydrops Fetalis/etiology ; Hydrops Fetalis/virology ; Hydrops Fetalis/therapy ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/diagnosis ; Erythema Infectiosum/epidemiology ; Erythema Infectiosum/diagnosis ; Erythema Infectiosum/therapy ; Pregnancy Outcome/epidemiology
    Language English
    Publishing date 2024-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391345-4
    ISSN 1533-9866 ; 0029-7828
    ISSN (online) 1533-9866
    ISSN 0029-7828
    DOI 10.1097/OGX.0000000000001263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Advances in Parvovirus Research 2020

    Gallinella, Giorgio

    2021  

    Keywords Public health & preventive medicine ; feline parvovirus ; virus-like particles ; VP2 protein ; antibodies ; AAV ; neuro-degenerative disease ; gene therapy ; antigenicity ; sequencing ; virus ; canine parvovirus ; peri-urban ; wild dogs ; disease transmission ; Australia ; parvovirus B19 ; G-quadruplex ; bioinformatics ; antivirals ; BRACO-19 ; pyridostatin ; oncolytic viruses ; rodent protoparvovirus H-1PV ; virus entry ; clathrin-mediated endocytosis ; parvovirus ; minute virus of mice ; RNA processing ; gene expression ; canine ; COVID-19 ; veterinary epidemiology ; B19V ; VP1u ; receptor ; PLA2 ; erythroid cells ; biomarker ; drug delivery ; nanocarrier ; B19 parvovirus ; detection ; cell cycle ; permissivity ; serotype ; capsid ; cryo-EM ; genome packaging ; gene delivery ; bocavirus ; Caribbean region ; new CPV-2a ; outbreak ; endemic ; nearly complete genomes ; virus evolution ; parvoviruses ; nucleus ; imaging of viral interactions and dynamics ; analysis of protein-protein interactions ; analysis of virus-chromatin interactions ; AMDV ; Aleutian disease ; mink parvovirus ; Aleutian mink disease virus ; vaccine
    Size 1 electronic resource (258 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289512
    ISBN 9783036524917 ; 3036524916
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: An Outbreak of Parvovirus B19 in Israel.

    Patalon, Tal / Saciuk, Yaki / Trotzky, Daniel / Pachys, Gal / Ben-Tov, Amir / Segal, Yaakov / Gazit, Sivan

    Viruses

    2023  Volume 15, Issue 11

    Abstract: Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection ... to previous years. When specifically comparing 2023 to COVID-19 years (2020-2022), adjusted IRR climbs to 9.21 ...

    Abstract Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening one. During pregnancy, it can lead to fetal loss and hydrops fetalis. This retrospective study examined the incidence rates of B19V in Israel, analyzing anonymized electronic medical records of 2.7 million individuals between January 2015 and September 2023. A generalized linear model with a Poisson distribution was fit to the data, adjusting for potential confounders. A marked increase in B19V was observed in 2023, with an adjusted incidence rate ratio (IRR) of 6.6 (95% CI 6.33-6.89) when comparing 2023 to previous years. When specifically comparing 2023 to COVID-19 years (2020-2022), adjusted IRR climbs to 9.21 (8.66-9.80). Moreover, in 2023, previously existing seasonality has largely disappeared. High SES characterized most infected individuals with a marked discrepancy in social sectors; the Arab population was significantly less likely to be found B19V positive, even when adjusting for SES. Most infections occurred in school-aged children (6-11 years old). Pregnant women experienced the most significant rise in B19V, with an adjusted IRR of 11.47 (9.44-13.97) in 2023 compared to previous years; most cases were diagnosed in the first trimester. This study demonstrates that Israel is currently experiencing the largest and longest reported outbreak of B19V to date. Policymakers should consider setting screening policies in place, at least for populations at risk, while specifically studying and potentially targeting low socioeconomic populations and specific social sectors to avoid health inequalities.
    MeSH term(s) Child ; Pregnancy ; Humans ; Female ; Parvovirus B19, Human/genetics ; Pregnancy Complications, Infectious ; Retrospective Studies ; Israel/epidemiology ; Parvoviridae Infections ; DNA, Viral
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15112261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Parvovirus B19-assoziierte inflammatorische Kardiomyopathie

    Kirste, Ariane Gertraud

    Untersuchungen zur Inhibiton der Virusreplikation

    2013  

    Author's details vorgelegt von Ariane Gertraud Kirste
    Language German
    Size VII, 125 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2013
    HBZ-ID HT017711216
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 D 641 order for loan Magazin

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  6. Book ; Thesis: Untersuchung zur Prävalenz von Parvovirus B19 im Lebergewebe bei Lebererkrankungen unterschiedlicher Genese

    Körner, Eva

    2017  

    Author's details vorgelegt von Eva Körner
    Language German
    Size VIII, 75 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2017
    HBZ-ID HT019403390
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Parvovirus B19 in stem cell transplantation.

    Kinsella, Paul M / Yong, Michelle K / Slavin, Monica A / Hall, Victoria G

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 5, Page(s) e14138

    MeSH term(s) Humans ; Parvovirus B19, Human ; Hematopoietic Stem Cell Transplantation/adverse effects ; Erythema Infectiosum ; Stem Cell Transplantation/adverse effects ; Parvoviridae Infections
    Language English
    Publishing date 2023-08-23
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14138
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: Hematologic Manifestations of Parvovirus B19 Infection.

    Algwaiz, Ghada / Alharbi, Abrar / Alsehaim, Khuloud / Alahmari, Ali / El Fakih, Riad / Aljurf, Mahmoud

    Hematology/oncology and stem cell therapy

    2023  Volume 16, Issue 4, Page(s) 316–322

    Abstract: Parvovirus B19 virus infection is widespread among humans because of its highly infectious and ...

    Abstract Parvovirus B19 virus infection is widespread among humans because of its highly infectious and obstinate nature, with up to 80% of the population testing positive for IgG antibodies against the virus. Pronormoblasts observed in biopsy are the hallmarks of PVB19 infection. In addition, PVB19 affects the skin, heart, brain, joints, and liver and can be diagnosed through antibody detection or DNA detection via PCR. Due to its capsid proteins' high affinity for bone marrow receptors, its main presentation is the suppression of bone marrow functions. It has been shown to affect patients with hemolytic anemia and patients with hematological malignancies, presenting with pure red cell aplasia. The main available effective treatment option is IV immunoglobulins; however, the risk of recurrence remains high after treatment.
    MeSH term(s) Humans ; Erythema Infectiosum/complications ; Erythema Infectiosum/pathology ; Bone Marrow/pathology ; Red-Cell Aplasia, Pure/therapy ; Parvovirus B19, Human/genetics ; Parvoviridae Infections/complications
    Language English
    Publishing date 2023-05-23
    Publishing country Saudi Arabia
    Document type Journal Article ; Review
    ZDB-ID 2651893-4
    ISSN 2589-0646 ; 1658-3876
    ISSN (online) 2589-0646
    ISSN 1658-3876
    DOI 10.56875/2589-0646.1031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Functional Minigenome of Parvovirus B19.

    Reggiani, Alessandro / Avati, Andrea / Valenti, Francesca / Fasano, Erika / Bua, Gloria / Manaresi, Elisabetta / Gallinella, Giorgio

    Viruses

    2022  Volume 14, Issue 1

    Abstract: Parvovirus B19 (B19V) is a human pathogenic virus of clinical relevance, characterized ... the B19V minigenome was able to complement B19-derived, NS1-defective genomes, restoring their ability ...

    Abstract Parvovirus B19 (B19V) is a human pathogenic virus of clinical relevance, characterized by a selective tropism for erythroid progenitor cells in bone marrow. Relevant information on viral characteristics and lifecycle can be obtained from experiments involving engineered genetic systems in appropriate in vitro cellular models. Previously, a B19V genome of defined consensus sequence was designed, synthesized and cloned in a complete and functional form, able to replicate and produce infectious viral particles in a producer/amplifier cell system. Based on such a system, we have now designed and produced a derived B19V minigenome, reduced to a replicon unit. The genome terminal regions were maintained in a form able to sustain viral replication, while the internal region was clipped to include only the left-side genetic set, containing the coding sequence for the functional NS1 protein. Following transfection in UT7/EpoS1 cells, this minigenome still proved competent for replication, transcription and production of NS1 protein. Further, the B19V minigenome was able to complement B19-derived, NS1-defective genomes, restoring their ability to express viral capsid proteins. The B19V genome was thus engineered to yield a two-component system, with complementing functions, providing a valuable tool for studying viral expression and genetics, suitable to further engineering for purposes of translational research.
    MeSH term(s) Cell Line ; Cloning, Molecular ; Genetic Engineering ; Genome, Viral ; Humans ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/physiology ; Replicon ; Transcription, Genetic ; Viral Nonstructural Proteins/biosynthesis ; Viral Nonstructural Proteins/genetics ; Virus Replication
    Chemical Substances NS1 protein, parvovirus ; Viral Nonstructural Proteins
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Parvovirus B19 Infection and Pregnancy: Review of the Current Knowledge.

    Dittmer, Fernanda Parciasepe / Guimarães, Clara de Moura / Peixoto, Alberto Borges / Pontes, Karina Felippe Monezi / Bonasoni, Maria Paola / Tonni, Gabriele / Araujo Júnior, Edward

    Journal of personalized medicine

    2024  Volume 14, Issue 2

    Abstract: Parvovirus B19, a member of the ...

    Abstract Parvovirus B19, a member of the
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14020139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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