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  1. Article ; Online: Invited Commentary on Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.

    Cucchiara, Brett

    Neurocritical care

    2021  Volume 34, Issue 3, Page(s) 720–721

    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01226-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction to: Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.

    Lang, Corinna N / Dettinger, Johanna S / Berchtold-Herz, Michael / Utzolino, Stefan / Bemtgen, Xavier / Zotzmann, Viviane / Schmid, Bonaventura / Biever, Paul M / Bode, Christoph / Müller-Peltzer, Katharina / Duerschmied, Daniel / Wengenmayer, Tobias / Niesen, Wolf-Dirk / Staudacher, Dawid L

    Neurocritical care

    2021  Volume 34, Issue 3, Page(s) 1112

    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01225-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.

    Lang, Corinna N / Dettinger, Johanna S / Berchtold-Herz, Michael / Utzolino, Stefan / Bemtgen, Xavier / Zotzmann, Viviane / Schmid, Bonaventura / Biever, Paul M / Bode, Christoph / Müller-Peltzer, Katharina / Duerschmied, Daniel / Wengenmayer, Tobias / Niesen, Wolf-Dirk / Staudacher, Dawid L

    Neurocritical care

    2021  Volume 34, Issue 3, Page(s) 739–747

    Abstract: ... of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear, however, if COVID-19 patients ... from 01/2018 to 05/2020. PCR-positive SARS-CoV-2 patients with ARDS were allocated to the COVID-19 group ... 0.028) were significantly more frequent in the COVID-19 patients. ICH was detected in 22 patients ...

    Abstract Background: Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear, however, if COVID-19 patients with acute respiratory distress syndrome (ARDS) with or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have more intracerebral hemorrhages (ICH) compared to other ARDS patients.
    Methods: We conducted a retrospective observational single-center study enrolling all patients with ARDS from 01/2018 to 05/2020. PCR-positive SARS-CoV-2 patients with ARDS were allocated to the COVID-19 group. Propensity score matching was performed for age, VV-ECMO, and bleeding risk.
    Results: A total of 163 patients with moderate or severe ARDS were identified, 47 (28.8%) in the COVID-19 group, and 116 (71.2%) in the non-COVID-19 group. In 63/163 cases (38.7%), VV-ECMO therapy was required. The ICU survival was 52.8%. COVID-19 patients were older, more often male, and exhibited a lower SOFA score, but the groups showed similar rates of VV-ECMO therapy. Treatments with antiplatelet agents (p = 0.043) and therapeutic anticoagulation (p = 0.028) were significantly more frequent in the COVID-19 patients. ICH was detected in 22 patients (13.5%) with no statistical difference between the groups (11.2 vs. 19.1% without and with SARS-CoV-2, respectively, p = 0.21). Propensity score matching confirmed similar rates of ICH in both groups (12.8 vs. 19.1% without and with SARS-CoV-2, respectively, p = 0.57), thus leveling out possible confounders.
    Conclusions: Intracerebral hemorrhage was detected in every tenth patient with ARDS. Despite statistically higher rates of antiplatelet therapy and therapeutic anticoagulation in COVID-19 patients, we found a similar rate of ICH in patients with ARDS due to COVID-19 compared to other causes of ARDS.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/therapy ; Cerebral Hemorrhage/virology ; Critical Care ; Extracorporeal Membrane Oxygenation ; Female ; Germany ; Humans ; Length of Stay ; Male ; Middle Aged ; Propensity Score ; Registries ; Respiration, Artificial ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; Retrospective Studies ; Risk Factors ; Survival Rate ; Young Adult
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01202-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study

    http://lobid.org/resources/99370671039106441#!, 34(3):739-747

    2021  

    Abstract: ... of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear, however, if COVID-19 patients ... from 01/2018 to 05/2020. PCR-positive SARS-CoV-2 patients with ARDS were allocated to the COVID-19 group ... 0.028) were significantly more frequent in the COVID-19 patients. ICH was detected in 22 patients ...

    Abstract Background: Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear, however, if COVID-19 patients with acute respiratory distress syndrome (ARDS) with or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have more intracerebral hemorrhages (ICH) compared to other ARDS patients.
    Methods: We conducted a retrospective observational single-center study enrolling all patients with ARDS from 01/2018 to 05/2020. PCR-positive SARS-CoV-2 patients with ARDS were allocated to the COVID-19 group. Propensity score matching was performed for age, VV-ECMO, and bleeding risk.
    Results: A total of 163 patients with moderate or severe ARDS were identified, 47 (28.8%) in the COVID-19 group, and 116 (71.2%) in the non-COVID-19 group. In 63/163 cases (38.7%), VV-ECMO therapy was required. The ICU survival was 52.8%. COVID-19 patients were older, more often male, and exhibited a lower SOFA score, but the groups showed similar rates of VV-ECMO therapy. Treatments with antiplatelet agents (p = 0.043) and therapeutic anticoagulation (p = 0.028) were significantly more frequent in the COVID-19 patients. ICH was detected in 22 patients (13.5%) with no statistical difference between the groups (11.2 vs. 19.1% without and with SARS-CoV-2, respectively, p = 0.21). Propensity score matching confirmed similar rates of ICH in both groups (12.8 vs. 19.1% without and with SARS-CoV-2, respectively, p = 0.57), thus leveling out possible confounders.
    Conclusions: Intracerebral hemorrhage was detected in every tenth patient with ARDS. Despite statistically higher rates of antiplatelet therapy and therapeutic anticoagulation in COVID-19 patients, we found a similar rate of ICH in patients with ARDS due to COVID-19 compared to other causes of ARDS.
    Keywords COVID-19 ; COVID-19/complications [MeSH] ; COVID-19/mortality [MeSH] ; COVID-19/therapy [MeSH] ; Cerebral Hemorrhage/therapy [MeSH] ; Cerebral Hemorrhage/virology [MeSH] ; Cerebral Hemorrhage/epidemiology [MeSH] ; Critical Care [MeSH] ; ARDS ; Adult [MeSH] ; Aged [MeSH] ; Aged, 80 and over [MeSH] ; Germany [MeSH] ; Extracorporeal Membrane Oxygenation [MeSH] ; Female [MeSH] ; Humans [MeSH] ; Intracerebral hemorrhage ; Original Work ; Length of Stay [MeSH] ; Male [MeSH] ; Middle Aged [MeSH] ; Survival Rate [MeSH] ; Propensity Score [MeSH] ; Retrospective Studies [MeSH] ; Registries [MeSH] ; Respiration, Artificial [MeSH] ; Respiratory Distress Syndrome/mortality [MeSH] ; Respiratory Distress Syndrome/therapy [MeSH] ; Respiratory Distress Syndrome/virology [MeSH] ; Risk Factors [MeSH] ; Young Adult [MeSH]
    Language English
    Document type Article
    Database Repository for Life Sciences

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