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  1. Article ; Online: Long-term effects of COVID-19 in solid organ transplantation recipients.

    Larrosa-Garcia, Maria / Garcia-Garcia, Sonia / Los-Arcos, Ibai / Moreso, Francesc / Berastegui, Cristina / Castells, Lluís / Gorgas Torner, Maria Q / Miarons, Marta

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 23, Issue 4, Page(s) e13677

    MeSH term(s) COVID-19 ; Humans ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients
    Language English
    Publishing date 2021-07-12
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5100: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Long-Term Assessment of Antibody Response to COVID-19 Vaccination in People with Cystic Fibrosis and Solid Organ Transplantation.

    Fuchs, Teresa / Appelt, Dorothea / Ellemunter, Helmut

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: ... low antibody response to SARS-CoV-2 vaccines in recipients of solid organ transplant compared ... than lung transplant recipients. This study is among the first to show long-term data with constantly elevated or even ... to the healthy population. Information on immune response in CF patients with solid organ transplantation is ...

    Abstract With the worldwide spread of SARS-CoV-2 disease, people with cystic fibrosis (CF), especially solid organ transplant recipients, have quickly been identified as a risk group for severe disease. Studies have shown low antibody response to SARS-CoV-2 vaccines in recipients of solid organ transplant compared to the healthy population. Information on immune response in CF patients with solid organ transplantation is limited, especially regarding long-term efficacy. The aim of this real-world study was a long-term assessment of humoral immune response induced by three and four doses of the SARS-CoV-2 mRNA vaccine. S1RBD and IgG antibodies were measured every 12 weeks over a period of 27 months in twelve CF patients (five liver and seven lung transplantation recipients). A total of 83.3% of our patients showed a positive antibody response after three doses of the SARS-CoV-2 mRNA vaccine. A sustained immune response was observed in both groups over the observation period, with liver transplant recipients showing higher levels than lung transplant recipients. This study is among the first to show long-term data with constantly elevated or even increasing antibody levels. We conclude that this effect is most likely associated with repeated boostering in terms of infections and booster vaccinations.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients.

    Favà, Alexandre / Donadeu, Laura / Jouve, Thomas / Gonzalez-Costello, José / Lladó, Laura / Santana, Carolina / Toapanta, Néstor / Lopez, Manuel / Pernin, Vincent / Facundo, Carme / Cabañas, Nuria Serra / Thaunat, Olivier / Crespo, Marta / Llinàs-Mallol, Laura / Revuelta, Ignacio / Sabé, Nuria / Rombauts, Alexander / Calatayud, Laura / Ardanuy, Carmen /
    Esperalba, Juliana / Fernandez, Candela / Lozano, Juan J / Preyer, Rosemarie / Strecker, Kevin / Couceiro, Carlos / García-Romero, Elena / Cachero, Alba / Meneghini, Maria / Torija, Alba / Le Quintrec, Moglie / Melilli, Edoardo / Cruzado, Josep Maria / Polo, Carolina / Moreso, Francesc / Crespo, Elena / Bestard, Oriol

    Kidney international

    2022  Volume 101, Issue 5, Page(s) 1027–1038

    Abstract: ... of COVID-19 severity. Thus, our study shows that patients with a solid organ transplant are capable ... of maintaining long-lasting peripheral immune memory after COVID-19 infection; mainly determined by the degree ... with a solid organ transplant. To investigate this, we performed a thorough evaluation of adaptive immune ...

    Abstract Long-term adaptive immune memory has been reported among immunocompetent individuals up to eight months following SARS-CoV-2 infection. However, limited data is available in convalescent patients with a solid organ transplant. To investigate this, we performed a thorough evaluation of adaptive immune memory at different compartments (serological, memory B cells and cytokine [IFN-γ, IL-2, IFN-γ/IL12 and IL-21] producing T cells) specific to SARS-CoV-2 by ELISA and FluoroSpot-based assays in 102 convalescent patients (53 with a solid organ transplants (38 kidney, 5 liver, 5 lung and 5 heart transplant) and 49 immunocompetent controls) with different clinical COVID-19 severity (severe, mild and asymptomatic) beyond six months after infection. While similar detectable memory responses at different immune compartments were detected between those with a solid organ transplant and immunocompetent individuals, these responses were predominantly driven by distinct COVID-19 clinical severities (97.6%, 80.5% and 42.1%, all significantly different, were seropositive; 84% vs 75% vs 35.7%, all significantly different, showed IgG-producing memory B cells and 82.5%, 86.9% and 31.6%, displayed IFN-γ producing T cells; in severe, mild and asymptomatic convalescent patients, respectively). Notably, patients with a solid organ transplant with longer time after transplantation did more likely show detectable long-lasting immune memory, regardless of COVID-19 severity. Thus, our study shows that patients with a solid organ transplant are capable of maintaining long-lasting peripheral immune memory after COVID-19 infection; mainly determined by the degree of infection severity.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunologic Memory ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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